Benzyl benzoate

General characteristics. Structure:

Active ingredient: benzylbenzoate;

1 g of cream contains benzyl benzoate medical – 250 mg;

excipients: emulsifier No. 1, propylene glycol, the water purified.

Pharmacological properties:

The drugs used at ektoparazitoza including a mange. X01 ATC P03A code.

Drug possesses acaricidal effect of rather different types of mites, including scabby (Acarus scabiei) and mites of the sort Demodex, shows protivopedikulezny activity.

Shows toxic action concerning all species of louses (death of louses occurs in 2-5 hours, ticks – in 7-32 minutes). Gets through a chitinous cover and collects in an organism of a tick in toxic concentration. Causes death of larvae and adult individuals of itch mites; does not affect eggs.

Indications to use:

Treatment of itch, pediculosis.

Route of administration and doses:

To apply benzyl benzoate of 25% locally. At one time to put 10-15 g of cream. To children to cover with cream all sites of skin, to apply to adults on all sites of skin, except the person and a pilar part of the head. At treatment of itch before use of drug it is necessary to take a hot shower with soap for removal of scales and crusts, to carefully wash away soap and to wipe a towel. Having squeezed out cream from a tuba, it is rubbed in skin. It is the best of all to carry out processing for the night, before going to bed. At a mange at first to process leather of the left and right hands, trunks (except for face skin and a pilar part of the head), and then skin of legs, soles and toes. In places with gentle skin (inguinal area, genitalias, chest glands), and also at eczema, dermatitis or a pyoderma it is necessary to apply carefully cream, not to rub. To apply cream to children on all integument in the same sequence. After processing of a hand it is not necessary to wash within 3 hours. In certain cases after drying of the applied cream (usually in 1 hour) it is recommended to put the second layer of drug. After the end of processing by the patient it is necessary to put on pure underwear, to replace bed linen. In 24-48 hours to take a shower and again to change linen and a bed. To apply cream on skin 4 times within 2 weeks with an interval of 3-4 days. 60-90 g of cream are spent for a course of treatment on average.

At treatment of itch at children up to 5 years cream just before use needs to be diluted with warm boiled water (30-35 °C) in the ratio 1:1 and to mix before formation of a homogeneous emulsion. Processing, as a rule, it is necessary to carry out without preliminary heat bath 2 times with an interval of 12 hours.

At treatment of the Norwegian itch before cream use Benzyl benzoate it is necessary previously by means of keratolytic means to clear integuments of crusts. Duration of a course of treatment is defined by dynamics of clarification of integuments, stopping of inflammatory process, the termination of an itch.

At treatment of a pediculosis to apply drug, slightly rubbing, on skin of a pilar part of the head and on hair, the head to tie up a scarf. In 30 minutes to wash away drug flowing water and hair to rinse warm 5% with vinegar solution. After the described procedure to wash out hair with soap or shampoo and to comb a frequent comb for removal of nits. At a pubic pediculosis to rub cream in skin of a pubis, a stomach, inguinal folds and internal surfaces of hips. Efficiency of processing is defined in a day and if necessary the procedure should be repeated.

Features of use:

Before an initiation of treatment the patient needs to take a hot shower for mechanical removal from the surface of leather of mites, and also for an epidermis blanket raspushivaniye (for drug penetration simplification). After each forced washing of hands they need to be processed again. Surely it is necessary to carry out processing of next-to-skin and bed linen, outerwear and headdresses.

It is necessary to avoid hit of drug in eyes and on mucous membranes. Upon termination of a course of treatment medical control within 14 days is necessary (and in the presence of complications – more).

At accidental hit of drug:

– in eyes: to wash out carefully water or in 1% Natrii hydrocarbonas solution; at irritation of a mucous membrane of eyes to dig in 30% albucid solution, at pain –   2% novocaine solution;

– in a mouth: to rinse a mouth water or warm 2% Natrii hydrocarbonas solution;

– in a stomach: at accidental administration of drug inside it is necessary to see a doctor immediately.

Processing of patients in one center, and also contact persons, it is necessary to carry out at the same time.

Complications in the form of pyodermas, eczemas it is necessary to treat along with a mange and to continue after its elimination.

Use during pregnancy or feeding by a breast.

Not to apply during pregnancy. For treatment feeding by a breast should be stopped.

Ability to influence speed of response at control of motor transport or work with other mechanisms. Does not influence.

Children. It is contraindicated to children up to 3 years.

Side effects:

At rubbing in of drug in skin there can be a burning sensation which disappears at further use of cream. In isolated cases persons with sensitive skin can have local skin reactions, a burning sensation or an itch, reddening or dryness of the site of leather which is processed by drug, and also allergic reactions. If the above-stated side effects do not disappear independently, use of drug needs to be stopped. Sensitivity of skin especially increased on the damaged sites and genitalias. There can sometimes be contact dermatitis. As drug contains propylene glycol, the irritation of skin is possible.

Interaction with other medicines:

Pharmacological interaction of cream Benzyl benzoate with other drugs it is not revealed, however, as well as for all antiparasitics, it is not recommended to be applied along with other medicines to external use. Topical or system administration of corticosteroids can promote disappearance or reduction of manifestations of some symptoms (an itch, a hyperemia) at preservation of an invasion therefore for treatment by cream Benzyl benzoate it is necessary to avoid use of such drugs.

Contraindications:

Hypersensitivity to benzyl benzoate or to other components of drug.

Injuries of skin, including pustulous diseases of skin.

Overdose:

At overdose strengthening of manifestations of side effects, for example contact dermatitis is possible.

At an accidental proglatyvaniye of cream or drawing very large number are possible: strengthening of side effects of drug, contact dermatitis, a sudden loss of consciousness, stimulation of the central nervous system (a spasm, including at children) and an urination delay.

Symptomatic treatment. Skin needs to be cleared of cream. At a proglatyvaniye of cream it is necessary to wash out a stomach, and then to accept absorbent carbon. If necessary to apply anticonvulsants.

In case of any undesirable reaction on site putting drug it needs to be washed away water with soap.

Storage conditions:

Period of validity. 3 years. Not to use drug after the termination of the period of validity specified on packaging. To store in the place, unavailable to children, at a temperature not over 25 ˚С.

Issue conditions:

Without recipe

Packaging:

On 40 g or 80 g in a tuba. On 1 tuba in a pack.