Gentaksan

General characteristics. Structure:

Main physical and chemical properties: amorphous powder of color, white or white with a light yellow shade, inodorous; structure: 1,0 g of powder contain Gentamycini sulfas in terms of gentamycin 24 mg, L-tryptophane of 14 mg and zinc of sulfate of 10 mg, Mitoxanum – enough for obtaining mass of powder of 1,0 g.

Pharmacological properties:

Pharmacodynamics. Gentaksan – the combined germicide of the prolonged action for topical administration which contains aminoglycoside Gentamycini sulfas, silicon an organic sorbent – methyl silicone (Mitoxanum) and coordination compound of zinc with tryptophane. Gentamycini sulfas – an antibiotic of a broad spectrum of activity with bactericidal effect, active in relation to pathogenic gram-positive microorganisms – Staphylococcus aureus, Streptococcus, Mycobacterium spp. and to gram-negative microorganisms – Pseudomonas aeruginosa, Aerobacter aeruginosa, Escherichia coli, Proteus spp., Klebsiella spp., Serratia spp., Shigella spp., Salmonella spp., Citrobacter spp., Providenta spp., Yerinia spp. Methyl silicone provides sorption and disintoxication properties and together with tsinktriptofany exponentiates antibacterial effects of an antibiotic and maintains antimicrobic concentration of an antibiotic in a wound at the therapeutic level within 8 days. Application therapy by Gentaksan reduces for the 2-3rd days quantity of microorganisms in a wound to the minimum level (102–103 in 1 g), accelerates transition of a phase of hydration to dehydration phase, prevents development of possible is purulent - septic complications. Thanks to sorption properties drug absorbs toxic waste products of microorganisms, low-molecular toxic metabolites of fabrics (pyroracemic and milk acids, peroxide connections, products of oxidation of amino acids, polypeptides, lipids, etc.), fibrin dehydration products. The mechanism of action of Gentaksan is connected not only with oppression of synthesis of protein of microorganisms, but also with disturbance of a lipidic layer of a cell wall, owing to formation of complexes. Gentaksan reduces the display of local and general intoxication owing to antibacterial properties draining and antiedematous action, normalization of microcirculation, gas exchange, рН Wednesdays in a wound. It promotes clarification of a wound from products of exudation and disintegration of fabrics, to disappearance of local inflammatory reactions, stimulation of growth of granulyatsionny fabric, healing process improvement, prevents formation of keloid cicatrixes. Gentaksan also clears wounds at burns, reduces inflammatory reactions at their treatment, reduces the area of deep burns, prevents destruction of fabrics, accelerates formation of a granulyatsionny cover at deep burns and epithelization at superficial burns, promotes high-quality preparation of wounds for an autodermoplastika.

Pharmacokinetics. It was not studied.

Indications to use:

• The infected surgical wounds (postoperative suppurations, phlegmons, abscesses);

• traumatic contaminated wounds of different localization and genesis;
• trophic ulcers which arise against the background of chronic venous insufficiency, obliterating atherosclerosis, thrombophlebitises of saphenas of the lower extremities;
• burns of the II-III A-III of B of degree;
• different forms of an erysipelatous inflammation;
• decubituses;
• wounds at patients with various diseases at which regenerative processes decrease (a diabetes mellitus, an immunodeficiency, radiation injury);
• prevention of sepsis at extensive purulent processes;
• prevention of formation of keloid cicatrixes.

Route of administration and doses:

Gentaksan to apply locally. Drug is used during the whole time of treatment of wounds before their full healing. In an initial stage (the 1-5th day) of a bandage change 1–2 times a day, after reduction of inflammatory processes, clarifications of a wound from it is purulent - necrotic masses, emergence of granulation and epithelization of a wound – 1 time within 1–2 days. Gentaksan give on a surface wounds through a stopper dropper (an opening in a stopper), having uncovered, after careful surgical treatment, a bathing of the wound solutions of antiseptic agents with obligatory subsequent dehumidification so that he covered with a uniform layer (0,5–1 mm) a wound surface. At extensive wound defeats, for example at burns, perhaps single-step use of 8-12 g of drug. After Gentaksan's drawing carry out drainage of a wound by the general rules and apply a bandage. At widespread wound defects of fabrics friable packing is allowed by gauze napkins. At a partial otkhozhdeniye of Gentaksan together with allocations from a wound and a bandage, the wound is dried gauze tupfer and in addition apply drug in the above-stated single dose without any other manipulations in a wound.
For treatment of burns Gentaksan apply on the burned surface both in the first 5–6 days, and in the period of sequestration of a burn scab (up to 15 days). At the same time drug is fixed on a wound by means of an aseptic bandage. During bandagings Gentaksan it is necessary to remove completely from a surface of burn wounds by means of antiseptic agents or special shampoos for wounds. Use of drug is possible on any parts of a body of the burn patient.
At injuries – when surgical treatment of a wound cannot be executed in full, – fill up with Gentaksan a wound in a dose of 0,5-4,0 g, depending on the area of defeat, and apply a bandage for a while which does not exceed 24 hours.

Features of use:

At topical administration drug has no local irritative effect, however it is impossible to allow Gentaksan's hits in eyes. Gentaksan it is possible to apply on a surface of wounds only after careful surgical treatment. Drug prevents sticking of bandages and emergence of pain at their removal.
Gentaksan it is possible to use at treatment of children as he is drug of not system use, works only superficially and has no resorptive effect.

Side effects:

At Gentaksan's use the side effects caused by existence of Gentamycini sulfas are possible (allergic reactions in the form of an erythema, a small tortoiseshell, contact dermatitis, an itch).

Interaction with other medicines:

It is not studied, however strengthening of action at local use with the antibiotics having bactericidal effect is possible.

Contraindications:

Hypersensitivity to Gentamycini sulfas and other components which are Gentaksan's part.

Overdose:

At overdose the allergic reactions demanding drug withdrawal and performing the desensibilizing therapy are possible.

Storage conditions:

To store in the dry, protected from light place at a temperature from 15 °Сдо 25 °C. A period of validity – 3 years.

Issue conditions:

Without recipe

Packaging:

On 2,0 g of powder in bottles or bottles droppers; on 5,0 g of powder in bottles droppers.