Витагамма®

General characteristics. Structure:

Active ingredients: 50 mg of Thiamini chloridum, 50 mg of a pyridoxine of a hydrochloride, 0,5 mg of cyanocobalamine, 10 mg of lidocaine of a hydrochloride.

Excipients: benzyl alcohol, sodium polyphosphate, potassium hexacyanoferrate, sodium hydroxide, water for injections.

Pharmacological properties:

Pharmacodynamics. Pharmacological action is defined by properties, the components which are a part of drug. B1, V6 and V12 vitamins regulate proteinaceous, carbohydrate and a lipometabolism, contribute to its normalization, improve function of motor, sensory and autonomic nerves.

Thiamin (B1) interferes with a protein glikolizirovaniye, has antioxidant activity, participates in regulation of carrying out nervous impulses.

The pyridoxine (B6) participates in synthesis of neurotransmitters (dopamine, noradrenaline, etc.), reactions of decarboxylation, a misinformation - and interaminations of amino acids, interferes with accumulation of ammonia and accelerates regenerative processes in nervous tissue.

Cyanocobalamine (B12) is necessary for a normal hemogenesis, participates in synthesis of myelin fabric.

Indications to use:

The neurologic diseases caused by the proved vitamin deficiency of B1, B6 and B12.

As supportive application for symptomatic therapy of diseases of a nervous system of various origin: neuritis and polyneurites (including followed by a pain syndrome), including retrobulbar neuritis, peripheral paresis (including a facial nerve), neuralgia, polyneuropathy (diabetic, alcoholic, etc.).

Route of administration and doses:

Deeply intramusculary, in hard cases and at acute pains enter daily 2 ml. After there will pass the aggravation or at easy forms of a disease enter 2-3 times a week 2 ml.

Side effects:

In some cases there can be an increased sweating, tachycardia, acne rash. Cases of development of skin allergic reactions (an itch, urticaria and other types of skin rash), and also system reactions (the complicated breath, a Quincke's edema, an acute anaphylaxis) are described.

In case of very bystry administration of drug can arise: dizziness, headache, vomiting, tachycardia or bradycardia, arrhythmia, spasms, excitement, cardialgia.

Interaction with other medicines:

Thiamin collapses in the solutions containing sulfites.

Therapeutic doses of B6 vitamin reduce effect of a levodopa.

Ions of copper, value рН more than 3 accelerate thiamin disintegration.

B12 vitamin is incompatible with salts of heavy metals. In the solutions containing thiamin, cyanocobalamine (as well as other vitamins of group B) quickly collapses (the low concentration of ions of iron which are present at drug can prevent it).

Contraindications:

Hypersensitivity to drug components; pregnancy and period of breastfeeding; fibrinferments and thromboembolisms; severe forms of dekompensirovanny heart failure; erythremia, hyperglobulia, heavy bleedings, arterial hypotension, depressed cases, children's age.

With care. Vernike's encephalopathy, premenopausal and a climacteric at women, the heavy stenocardia, high-quality and malignant new growths which are followed by megaloblastny anemia and deficit of B12 vitamin, tendency to formation of blood clots, advanced age (65 years are more senior).

Overdose:

At overdose there is strengthening of symptoms of side effect of drug, symptomatic therapy is carried out.

Storage conditions:

In protected from light, the place, unavailable to children, at a temperature not above 15 °C. A period of validity - 2 years. Not to use after the term specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Solution for intramuscular introduction in ampoules of 2 ml.

On 5 ampoules in a blister strip packaging. 1, 2 blister strip packagings together with the application instruction and a knife ampoule or the scarificator ampoule place in a pack from a cardboard. When using ampoules with a point, a break ring the knife ampoule or the scarificator is not put.