Thioctic acid

General characteristics. Structure:

Active ingredient: 5 mg of thioctic acid in 1 ml of solution.

The drug rendering gepatoprotektivny, disintoxication, gipokholesterinemichesky, hypolipidemic, antioxidant action.

Pharmacological properties:

Pharmacodynamics. Is a coenzyme of oxidizing decarboxylation of pyruvic acid and alpha ketonic acids, normalizes power, carbohydrate and lipidic exchanges, regulates cholesterol metabolism. Improves functions of a liver, reduces the damaging influence on it of endogenous and exogenous toxins.

Pharmacokinetics. After intake it is quickly and rather fully soaked up from a GIT (reception with food reduces absorption), Cmax  is reached within 25–60 min. Bioavailability makes 30–60% (owing to presistemny biotransformation). In a liver is oxidized and conjugates. Distribution volume — about 450 ml/kg. It is excreted by kidneys in the form of metabolites (80–90%) since T1/2 20–50 min. The general plasma Cl — 10–15 ml/min.

Indications to use:

Parenterally, inside 300 and 600 mg: diabetic and alcoholic polyneuropathy.

Inside 12 and 25 mg: fatty dystrophy of a liver, cirrhosis, chronic hepatitis, hepatitis A, intoxications (including salts of heavy metals), poisoning with a death angel, a lipidemia (including with development of coronary atherosclerosis — treatment and prevention).

Route of administration and doses:

In/in, inside. At neuropathy: in/in slowly (with a speed up to 50 mg/min.), 300–600 mg in the form of infusion on normal saline solution once a day during 2–4 weeks, then inside — on 300–600 mg of 1 times a day.

At diseases of a liver and intoxications: inside, the adult — on 50 mg 3–4 times a day. To children 6 years — po12-24mg 2-3 times a day are more senior. A course of treatment — 20-30dny. If necessary carrying out a repeated course in 1 month is possible.

Features of use:

Use at pregnancy and feeding by a breast. At pregnancy it is possible if the expected effect of therapy exceeds potential risk for a fruit.

The category of action on a fruit — is not determined by FDA. For the period of treatment it is necessary to stop breastfeeding.

During treatment regular control of concentration of glucose in blood (especially at the beginning of therapy) at patients with a diabetes mellitus is necessary. Patients are recommended to abstain from reception of alcoholic beverages during treatment.

Side effects:

From bodies of a GIT: at intake — nausea, vomiting, an abdominal pain, diarrhea.

Allergic reactions: skin rash, itch, small tortoiseshell, acute anaphylaxis.

Others: headache, disturbance of metabolism of glucose (hypoglycemia); at bystry in introduction — a short-term delay or difficulty of breath, increase in intracranial pressure, a spasm, a diplopia, dot hemorrhages in skin both mucous and tendency to bleeding (because of disturbance of functions of thrombocytes).

Interaction with other medicines:

Strengthens effects of peroral hypoglycemic drugs and insulin (the dose decline of hypoglycemic means can be required).

Thioctic acid (in the form of solution for infusions) reduces efficiency of Cisplatinum.

Thioctic acid (in the form of solution for infusions) is incompatible with dextrose solution, Ringer's solution, and also with the connections (including their solutions) interacting with disulfide and SH groups.

Alcohol can reduce efficiency of thioctic acid.

Contraindications:

Hypersensitivity, children's age up to 6 years (up to 18 years at treatment of diabetic and alcoholic polyneuropathy).

Overdose:

Symptoms: headache, nausea, vomiting.

Treatment: symptomatic therapy, maintenance of the vital functions. The specific antidote is unknown.

Storage conditions:

To store at a temperature of 15-25 °C, in dry, protected from light and the place, unavailable to children. Period of validity 3 years. Not to use after the expiry date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Solution for injections of 5 mg/ml, on 2 ml in each ampoule. On 5 or on 10 ampoules in cardboard packaging.