Антиоксикапс with iodine

General characteristics. Structure:

Active ingredients: 6 mg of beta carotene, 15 mg of alpha tocopherol of acetate (vitamin E), 75 mg of ascorbic acid (vitamin C), 0,131 mg of potassium of iodide (in terms of iodine – 0,1 mg).

Excipients: the sunflower oil refined the beeswax, lecithin purified.

Structure of a cover: gelatin pharmaceutical, глицерол, methylparahydroxybenzoate, пропилпарагидроксибензоат, the water purified titanium dioxide, dye (E129) "red charming".

Pharmacological properties:

Pharmacodynamics. Pharmacological activity of Antioksikaps with iodine is caused by complex effect of the vitamins which are contained in it: ascorbic acid, α-tocopherol of acetate, beta carotene and iodine.

Ascorbic acid participates in regulation of oxidation-reduction processes in an organism, activates carbohydrate protein metabolism, increases cholesterol metabolism, increases coagulability of blood, strengthens an angenesis, synthesis of steroid hormones, collagen and procollagen, promotes iron absorption improvement. It raises adaptation opportunities of an organism and strengthens its resilience to infections.

α-tocopherol acetate inhibits oxidation of fats in an organism and education from them toxic peroxides, stabilizing durability of bonds in unsaturated fatty acids. It normalizes structure and function of membranes of erythrocytes, endotheliocytes, enterocytes, etc. Tocopherol participates in collagen biosynthesis, gem and proteins, activates proliferation of cells, function of tissue respiration and other major processes of cellular metabolism. It stimulates formation of gonadotrophins, a spermatogenesis, development of an oosperm, placenta.

Beta carotene possesses antioxidant, immunomodulatory and antiinflammatory action due to ability to binding of active oxygen that protects cellular structures from destruction by the free radicals who are formed in a large number at influence of adverse environmental factors or at development of pathological processes in an organism.

Iodine, actively influencing a metabolism and strengthening dissimilation processes, it is necessary for endogenous synthesis of hormones of a thyroid gland, and also for providing a normal morfofunktsionalny condition of a thyroid gland. At intake of iodides in cells of an epithelium of a follicle of a thyroid gland iodide ions under the influence of enzyme iodide-peroxidase are oxidized with formation of elementary iodine which joins in a tyrosine molecule. At the same time one part of radicals of tyrosine in thyreoglobulin is iodated with formation of tironin, thyroxine (T4) and triiodothyronine (T3) are basic of which. Tironina form a complex with protein thyreoglobulin which is deposited in a colloid of a follicle of a thyroid gland.

Also influence of iodine on lipidic and protein metabolism is known.

Indications to use:

As polyvitaminic antioxidant drug of Antioksikaps with iodine is shown:

- in complex therapy of a diffusion nontoxic craw at teenagers and adults;

- for completion of an iodine deficiency and, therefore, for prevention of a local craw and a recurrence of a craw after its surgical removal, and also upon termination of complex therapy of a craw drugs of hormones of a thyroid gland;  

- for prevention and treatment vitamin (With, E and A) insufficiency;

- for increase in body resistance to catarrhal diseases;

- at the raised exercise and intellectual stresses;

- during recovery after the long and/or hard proceeding diseases, including infectious;

- at asthenic conditions of various etiology;

- at unbalanced and defective food.

Route of administration and doses:

Антиоксикапс with iodine accept after food, washing down with water.

With the preventive purpose teenagers are recommended to appoint drug from 14 years and the adult on 1 capsule of 1 times a day within 1-3 months.

The preventive course is recommended to be repeated several times a year.

With the medical purpose of a dose of Antioksikaps with iodine the doctor depending on character and degree of manifestation of pathology, and also taking into account the need of an organism for vitamins A, With, E and iodine establishes.

Features of use:

Антиоксикапс with iodine it is not necessary to appoint at a hypothyroidism unless the last is caused by the expressed iodine deficiency.

Use of drug it is necessary to avoid at therapy by a radioiodine, at cancer of a thyroid gland.

It is necessary to consider that at patients with renal failures development of a hyperpotassemia against the background of drug use is possible.

At prolonged use and at hypersensitivity to iodine the iodism phenomena are possible (cold, urticaria, a Quincke's edema, etc.); in these cases drug is cancelled.

At pregnancy and in the period of a lactation it is necessary to consider that iodine well gets through a placenta and is allocated with breast milk.

Simultaneous use with other polyvitaminic complexes in order to avoid overdose is not recommended.

Does not influence a possibility of driving of the car and work with the equipment.

Side effects:

From the alimentary system: seldom – metal smack, vomiting, diarrhea;

From TsNS: seldom – concern, a headache;

From endocrine system: at prolonged use of drug in high doses (more than 300 mkg/days) – iodine - the induced hyperthyroidism (especially at elderly patients, in the presence of a nodal craw or toxic adenoma); in some cases at therapy in very high doses (more than 1 mg/days) – a craw and a hypothyroidism;

Allergic reactions: seldom – iodic rhinitis, iodic dermatitis, a Quincke's edema; in some cases – iodic fever, iodic eels, hypostasis of sialadens.

Side effects are improbable at Antioksikaps's use with iodine according to indications in the recommended doses.

Interaction with other medicines:

The lack of iodine strengthens, and its surplus weakens action of the tireostatik applied at a hyperthyroidism. Perchlorate and potassium thiocyanate suppress iodine absorption by a thyroid gland.

Thyritropic hormone improves digestion of iodine a thyroid gland and stimulates production of its hormones.

At simultaneous use of drug in high doses with kaliysberegayushchy diuretics development of a hyperpotassemia is possible. Simultaneous use of Antioksikaps with iodine in high doses and drugs of lithium promotes development of a craw and a hypothyroidism.

Corticosteroid drugs, antibiotics of tetracycline group, and also ethanol and etanolsoderzhashchy drugs at joint presence reduce therapeutic effect of provitamin A.

Tocopherol can increase efficiency of anticonvulsants at patients with epilepsy at whom the increased content in blood of products of peroxide oxidation of lipids is revealed.

Absorption of ascorbic acid decreases at simultaneous use of oral contraceptives and, at the same time, vitamin C increases absorption of penicillin, iron, increases risk of emergence of a crystalluria at treatment by salicylates.

Contraindications:

Contraindication to use of drug are:

- manifest hyperthyroidism;

- a subclinical hyperthyroidism (at use of the doses exceeding 150 mkg/days of iodine);

- herpetiform dermatitis of Dyuringa;

- toxic adenoma, a nodal craw at use in a dose more than 300 mkg/days (except for preoperative therapy for the purpose of blockade of function of a thyroid gland);

- hypersensitivity to its components;

- children's and teenage age up to 18 years;

- pregnancy.

Overdose:

Data on overdose of drug of Antioksikaps with iodine are not provided.

Storage conditions:

Drug should be stored in the unavailable to children, dry, protected from light place at a temperature from 15 °C to 25 °C. A period of validity - 2 years.

Issue conditions:

According to the recipe

Packaging:

On 10 capsules in a blister strip packaging, on the 2nd blister strip packagings together with the application instruction in a pack from a cardboard bandbox.