Nebula soda buffer

General characteristics. Structure:

Active ingredient: 100 ml of solution contain 4,2 g of Natrii hydrocarbonas;

excipients: ethylene diamine tetraacetic acid disodium salt, carbon dioxide, water for injections.

Pharmacological properties:

Pharmacodynamics. Means for recovery of an alkaline condition of blood and correction of a metabolic acidosis. At dissociation of Natrii hydrocarbonas bicarbonate anion is released, it connects hydrogen ions with formation of carbonic acid which then breaks up to water and the carbon dioxide emitted at breath. The solution brought to an indicator рН 7,3 - 7,8 warns spasmodic залужнювання and provides smooth correction of acidosis at simultaneous increase in alkaline reserves of blood. Drug increases also allocation from an organism of ions of sodium and chlorine, raises an osmotic diuresis, alkalizes urine, the deposit of uric acid in an urinary system warns. In cells bicarbonate anion does not get.

Pharmacokinetics. It is not investigated.

Indications to use:

Noncompensated metabolic acidosis at various diseases, such as intoxications of various etiology, including poisonings with weak organic acids (for example, barbiturates, acetylsalicylic acid), a heavy current of the postoperative period, widespread deep burns, shock, a diabetic coma, long diarrhea, pernicious vomiting, acute massive blood losses, severe damages of a liver and kidneys, long feverish states, a heavy hypoxia of newborns. The absolute indication is decrease рН blood lower than 7,2.

Route of administration and doses:

Appoint to adults and children 1 years in/in kapelno with a speed of 1,5 mmol/kg/h (3 ml of 4,2% of the soda buffer/kg/p) under control рН are aged more senior than blood and indicators of acid-base and water and electrolytic balance of an organism. The newborn enter in/in in a dose of 1-2 ml on 1 kg of body weight.
In case of a korrigirovaniye of a metabolic acidosis dosing is defined with the level of disturbance of balance of acids and the bases. The dose is calculated depending on indicators of gas composition of blood on formule:objy 0,5-molar buferirovanny hydrosodium carbonate of 4,2% in ml = deficit of bases (– VE) x kg of body weight of the patient x 0,3 x 2 where (the factor 0,3 corresponds to a particle of volume of extracellular liquid in comparison with the volume of the general liquid). The maximum dose of drug for adults — 300 ml (at excess body weight — 400 ml/days); for children depending on body weight — from 100 to 200 ml/days.

Features of use:

It is necessary to control рН blood and an acid-base condition of blood. At patients with associated diseases of heart or kidneys heart failure and hypostases can develop. In case of too bystry compensation of acidosis, in particular at disturbance of ventilation of the lungs, bystry release of CO2 can strengthen cerebral acidosis. Period of pregnancy and feeding by a breast. The research concerning bicarbonate sodium influence on reproductive function of animals was not conducted. It is not known whether sodium bicarbonate exerts an adverse effect on a fruit when it is appointed during pregnancy and also whether it can influence reproductive function. Therefore drug during this period is appointed when the expected advantage for mother exceeds potential risk for a fruit.

Side effects:

Nausea, vomiting, anorexia, stomach ache, headache, concern, AG.

Interaction with other medicines:

In solution Soda buffer it is impossible to dissolve acid substances (ascorbic, nicotinic and other acids), alkaloids (atropine, Apomorphinum, caffeine, theobromine, a papaverine, etc.), cardiac glycosides, salts of calcium, magnesium, heavy metals (iron, copper, zinc) as there is a loss of a deposit or hydrolysis of organic compounds. Not to mix with fosfatsoderzhashchy solutions. Can strengthen anti-hypertensive effect of Reserpinum. Small amounts of the drug Soda buffer which are entered together with other infusional solutions having acid рН serve as the neutralized agent and prevent developing of post-infusional phlebitis (solution of glucose of different concentration, Ringer's solution, chloride sodium solution, ciprofloxacin and some other ftorkhinolona).

Contraindications:

Metabolic or respiratory alkalosis, hypopotassemia, hypernatremia.

Overdose:

Owing to buffer properties of drug reliability of development of an alkalosis at overdose is significantly reduced. At exceeding of a dose of drug development of an alkalosis, hypernatremia and hyperosmia, tetanic spasms is possible. At clinical manifestations of an alkalosis (a spasm, including with manifestations of a tetany, excitement, decrease in level of potassium and calcium and increase in level of sodium in blood serum, level рН) stop administration of drug, if necessary enter an isotonic rasvor of sodium of chloride or 5% glucose solution. At danger of development of a tetany enter into adult 1–3 g of calcium of a gluconate.

Storage conditions:

To store at a temperature from 15 to 25 °C.

Issue conditions:

Without recipe

Packaging:

One-dose containers on 2 ml, 10 pieces in packaging