Tsiprofloksatsin-akos

General characteristics. Structure:

Description: drops eye 0.3% in the form of transparent solution of yellowish or yellowish-greenish color.

Active ingredient: 1 ml ciprofloxacin (in the form of a hydrochloride) 3 mg;

Excipients: disodium salt of ethylene diamine tetraacetic acid, Mannitolum or a mannitol, sodium acetate anhydrous or three-water, acetic acid ice, a benzalkoniya chloride, water for and.

Pharmacological properties:

Antimicrobic drug, derivative ftorkhinolona. Works bakteritsidno. Inhibits bacterial DNK-girazu (the topoisomerases II and IV responsible for process of superspiralling of chromosomal DNA around nuclear RNA that is necessary for reading of genetic information), breaks DNA synthesis, growth and division of bacteria, causes the expressed morphological changes (including a cell wall and membranes) and bystry death of a bacterial cell.

Affects bakteritsidno gram-negative microorganisms during a dormant period and divisions (since influences not only on DNK-girazu, but also causes a lysis of a cell wall), on gram-positive microorganisms – only during division.

The hypotoxicity for cells of a macroorganism is explained by absence in them DNK-girazy. Against the background of reception of ciprofloxacin there is no parallel development of resistance to other antibiotics which are not belonging to group of inhibitors of a giraza that does drug highly effective concerning bacteria which are steady, for example, against aminoglycosides, penicillin, cephalosporins, tetracyclines and many other antibiotics.

Ciprofloxacin is active concerning gram-negative aerobic bacteria: Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp., Morganella morganii, Vibrio spp., Yersinia spp., Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp., Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp.; gram-positive aerobic bacteria: Staphylococcus spp. (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Streptococcus pyogenes, Streptococcus agalactiae.

Drug is also active concerning some intracellular activators (Legionella pneumophila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Corynebacterium diphtheriae).

Streptococcus pneumoniae, Enterococcus faecalis, Mycoplasma hominis, Gardnerella spp are moderately sensitive to drug., Mycobacterium avium-intracellulare (for their suppression high concentration are required).

Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides are steady against drug.

Drug is inactive concerning Treponema pallidum.

The majority of the stafilokokk steady against Methicillinum, rezistentna and to ciprofloxacin. Resistance of sensitive activators develops extremely slowly as on the one hand, after effect of ciprofloxacin there is practically no persistent microorganism left, and with another – bacterial cells have no enzymes inactivating it.

 

Pharmacokinetics. The registered Cmax in a blood plasma when using eye drops – less than 5 ng/ml. Average concentration – is lower than 2.5 ng/ml.

Indications to use:

— acute and subacute conjunctivitis;

— the blepharitis, blefarokonjyunktivit;

— keratitis, keratoconjunctivitis;

— bacterial helcoma;

— chronic dacryocystitis;

— meibomitis;

— infectious damages of eyes after injuries or hit of foreign bodys;

— before - and postoperative prevention of infectious complications in an ophthalmosurgery.

Route of administration and doses:

At slight and moderately heavy infection eye drops are dug in on 1-2 drops in the lower conjunctival sac of the affected eye (or both eyes) by each 4 h, at a heavy infection – on 2 drops each hour. After improvement of a state the dose and frequency of instillation are reduced.

The bottle needs to be closed after each use. It is not necessary to touch with a pipette tip an eye.

Features of use:

With care patients should appoint drug with atherosclerosis of vessels of a brain, disturbance of cerebral circulation, a convulsive syndrome.

Tsiprofloksatsin-AKOS it is possible to apply only locally. It is impossible to administer the drug subkonjyunktivalno or directly in an anterior chamber of an eye.

The patient should be informed that if after use of drops the long time proceeds or the conjunctival hyperemia accrues, then it is necessary to stop use of drug and to see a doctor.

During treatment drug does not recommend carrying soft contact lenses. When using rigid contact lenses it is necessary to remove them before an instillation and again to dress in 15-20 min. after drug instillation.

Influence on ability to driving of motor transport and to control of mechanisms

Patients at whom after application of eye drops of Tsiprofloksatsin-AKOS sight clearness is temporarily lost are not recommended to drive the car or to work with a difficult technique, machines or any other difficult equipment demanding sight clearness right after a drug instillation.

Side effects:

Local reactions: are possible - allergic reactions, an itch, burning, easy morbidity and a hyperemia of a conjunctiva, nausea; seldom – the century, a photophobia, dacryagogue, feeling of a foreign body in eyes, unpleasant smack in a mouth right after an instillation, decrease in visual acuity, emergence of white crystal precipitated calcium superphosphate in patients with a helcoma, a keratitis, a keratopathy, emergence of spots or infiltration of a cornea swelled.

Interaction with other medicines:

Interaction of eye forms of ciprofloxacin with other drugs is not described.

Contraindications:

— virus keratitis;

— children's age till 1 year;

— individual sensitivity to drug components.

 

Use of drug TSIPROFLOKSATSIN-AKOS of a drop eye at pregnancy and feeding by a breast
Use of the drug Tsiprofloksatsin-AKOS is possible only if the expected medical effect exceeds risk of development of possible side effects.

 

Use for children
Drug is contraindicated to children till 1 year.

Overdose:

Data on overdose of the drug Tsiprofloksatsin-AKOS are absent.

Storage conditions:

Eye drops should be stored in protected from light and the place, unavailable to children, at a temperature from 15 °C to 25 °C. A period of validity – 2 years; after opening of a bottle - no more than 1 month.

Issue conditions:

According to the recipe

Packaging:

5 ml - a bottle dropper polyethylene (1) - packs cardboard.