Ciprofloxacin таб. покр. obol. 0,25; 0.5 No. 10

General characteristics. Structure:

Structure: 1 tablet contains ciprofloxacin a hydrochloride (in quantity, equivalent 0,25 or 0,5 g of ciprofloxacin) - 0,2911 and 0,5822 g; excipients.

Pharmacological properties:

Antibacterial agents of group of hinolon.
Synthetic antibacterial drug with a broad spectrum of activity.
Has the bactericidal effect caused by inhibition of activity DNK-girazy of bacteria. To drug there is no plazmidooposredovanny resistance. It is highly active concerning gram-negative bacteria (Enterobacteriaceae, including E.coli,
Salmonella, Klebsiella, Shigella, Proteus mirabilus, Proteus vulgaris, Klebsiella oxytoca, Yersinia enterocolitica, Enterobacter, Citrobacter, Morgenella morganii; others gram-negative microorganisms, including Pseudomonas aeruginosa, Haemophilus influenzae, Acinetobacter, Campylobacter, Brucella melitensis, Pasteurella multocida, Eikenella corrodenus, Flavobacterium, Moraxella, Gardnerella vaginalis, kinds of Legionella, Vibrio cholerae and Vibrio parahemolyticus, Neisseria meningitis and Neisseria gonorrhoeae, including the strains producing - lactamelements), gram-positive bacteria (Staphylococcus aureus, including producing - lactamelements and strains, Streptococcus pneumonia, resistant to Methicillinum, - hemolitic streptococci of group A, streptococci of group B and other streptococci, Enterococci, including Enterococcus faecalis, Corynebacterium, Listiria monocytogenes) and other microorganisms, including anaerobic bacteria and some strains of bacteroids.
Ciprofloxacin is effective concerning microorganisms, resistant to other antibiotics (aminoglycosides, penicillin, tetracyclines), and also to Acidum nalidixicum.

Pharmacokinetics. Ciprofloxacin is quickly soaked up from a digestive tract. Bioavailability after intake makes 70%. Meal moderately slows down its absorption, but does not change its bioavailability. Linkng with proteins of plasma - 20-40%. Is exposed to effect of primary passing through a liver. It is widely distributed in fabrics and biological liquids of an organism that favourably distinguishes it from aminoglycosides and - laktamny antibiotics which have the small volume of distribution. Creates high concentration in a prostate gland, lungs, a bone tissue, a bronchial secret, bile. Gets through a placenta, it is allocated with breast milk. It is removed with urine and bile, it is preferential in not changed look. An elimination half-life - 3-5 h. Patients with an impaired renal function have a concentration of drug in a blood plasma and an elimination half-life increase. The considerable concentration of drug exceeding MPK for the majority of sensitive bacteria remain in urine and Calais within several days after the therapy termination.

Indications to use:

The infectious and inflammatory diseases caused by microorganisms, sensitive to drug: infections of respiratory, uric ways, ENT organs, skin and soft tissues, bones and joints, abdominal organs, gynecologic infections, gonorrhea, osteomyelitis, septicaemia, preoperative prevention and postoperative treatment of surgical infections. Ciprofloxacin is applied to prevention and treatment of patients with an immunosuppression.

Route of administration and doses:

Inside, irrespective of meal. The dose is established individually depending on weight of an infection, age, body weight and function of kidneys of the patient.
The recommended doses for adults:
- respiratory infections: 500-750 mg 2 times a day;
- infections of skin and soft tissues, bones and joints: 500-750 mg 2 times a day;
- infections of a digestive tract: 250-500 mg 2 times a day;
- gonorrhea: 250 mg inside once;
- not gonococcal urethritis: 750 mg 2 times a day;
- шанкроид: 500 mg 2 times a day;
- other infections: 500-750 mg 2 times a day.
Patients during treatment should drink a lot of water.
Children are not recommended to appoint drug. If the expected therapeutic effect exceeds potential risk, drug can be appointed in a dose 5-10¼ú/kg in days in 2 receptions.
Duration of treatment of acute infections makes 5-7 days. Therapy should be continued within 3 days after disappearance of symptoms of an infection.

Features of use:

In order to avoid development of a crystalluria, exceeding of the recommended daily dose is inadmissible, sufficient consumption of liquid and maintenance of acid reaction of urine is necessary.
During treatment it is necessary to abstain from occupations potentially dangerous types of activity requiring special attention and speed mental and motor reactions.
At emergence during treatment of heavy and long diarrhea it is necessary to exclude the diagnosis of pseudomembranous colitis which demands immediate drug withdrawal and purpose of the corresponding treatment. At emergence of pains in sinews or at emergence of the first symptoms of a tendovaginitis treatment should be stopped. During treatment it is necessary to avoid contact with direct sunshine.

Side effects:

It is usually well transferred. Diarrhea, vomiting, an abdominal pain, a headache, a faint, spasms, concern, skin rash, photodermatoses are sometimes possible; seldom - an arthralgia, increase in activity of serumal transaminases, heartbeat, an arterial hypertension, pain in a breast, vision disorders, anaphylactic reactions, it is extremely rare - an acute renal failure and pseudomembranous colitis.

Interaction with other medicines:

Ciprofloxacin can increase concentration in blood serum and increase a theophylline elimination half-life at simultaneous use. Drug can increase a prothrombin time at co-administration with indirect anticoagulants of a coumarinic row. The antacids containing magnesium hydroxide and/or aluminum can interfere with ciprofloxacin absorption; the interval between use of antacids and ciprofloxacin has to make 1-2 hours.

Contraindications:

Hypersensitivity to ciprofloxacin or other hinolona, epilepsy, age up to 18 years, the period of pregnancy and a lactation.

Overdose:

Symptoms: strengthening of side effects of drug. It is necessary to control carefully a condition of the patient, to make a gastric lavage, to carry out usual measures of acute management, to provide sufficient intake of liquid. By means of haemo - or peritoneal dialysis the amount of drug can be removed insignificant (less than 10%).

Storage conditions:

To store in dry, protected from light and the place, unavailable to children.

Period of storage - 2 years.

Issue conditions:

Without recipe

Packaging:

On 10 tablets in a blister strip packaging