MB anti-walls

General characteristics. Structure:

Active agent: a trimetazidina dihydrochloride - 35 mg;

Excipients (kernel): a gipromelloza - 93,0 mg, cellulose of microcrystallic-178,9 mg, silicon dioxide colloid - 1,55 mg, magnesium stearate - 1,55 mg.

    Excipients    (cover): Опадрай II 85F240012 Pink: polyvinyl alcohol - 4,0 mg, a macrogoal of 3350 - 2,438 mg, dye ferrous oxide red - 0,04 mg, dye ferrous oxide yellow - 0,022 mg, talc - 1,48 mg, titanium dioxide - 2,02 mg.

Pharmacological properties:

Pharmacodynamics. Has anti-hypoxemic effect. Directly influencing cardiomyocytes and neurons of a brain, drug optimizes their metabolism and function. The cytoprotective effect is caused by increase in energy potential, activation of oxidizing decarboxylation and rationalization of consumption of oxygen (strengthening of glycolysis and blockade of oxidation of fatty acids). Trimetazidin maintains contractility of a myocardium, prevents decrease in intracellular content of adenosine triphosphoric acid (ATP) and phosphocreatinine. In the conditions of acidosis normalizes functioning of ion channels of membranes, interferes with accumulation of calcium ions and sodium in cardiomyocytes, normalizes the intracellular maintenance of potassium ions. Reduces intracellular acidosis and the increased content of phosphates caused by ischemia of a myocardium and reperfusion. Interferes with the damaging action of free radicals, keeps integrity of cellular membranes, prevents activation of neutrophils in an ischemia zone, increases duration of electric potential, reduces an exit of a kreatinfosfokinaza (KFK) from cells and expressiveness of ischemic injuries of a myocardium. Trimetazidin reduces the frequency of attacks of stenocardia, reduces the need for reception of nitrates: in 2 weeks of reception increases tolerance to an exercise stress, sharp fluctuations of the arterial pressure (AP) decrease. Reduces dizziness and a sonitus of an ischemic etiology. At vascular pathology of eyes recovers functional activity of a retina of an eye.

Pharmacokinetics. After administration of drug inside триметазидин it is quickly and almost completely absorbed in digestive tract. Bioavailability of-90%. Time of achievement of the maximum concentration in a blood plasma - 3-5 h. The stable state is reached in 60 h. The volume of distribution makes 4,8 l/kg. Communication with proteins of a blood plasma - 16%. Trimetazidin is brought from an organism generally by kidneys (about 60% - in an invariable look). The elimination half-life about 7 h, at patients is more senior than 65 years - about 12 h. The renal clearance of a trimetazidin directly correlates with the clearance of creatinine (CC), the hepatic clearance decreases with age. Easily gets through gistogemetichesky barriers.

Indications to use:

Coronary heart disease: prevention of attacks of stenocardia (in complex therapy). Kokhleovestibulyarny disturbances of the ischemic nature, such as dizzinesses, sonitus, hearing disorder.
Chorioretinal vascular disorders.

Route of administration and doses:

Inside, during meal.
Anti-walls of MB appoint on 1 tablet 2 times a day (in the morning and in the evening).
Course of treatment - according to the recommendation of the doctor.

Features of use:

Not to apply to stopping of attacks of stenocardia!
Drug is not shown for an initial course of therapy of unstable stenocardia or a myocardial infarction.
In case of development of an attack of stenocardia it is necessary to reconsider and adapt treatment.
At the admission of one or more administrations of drug it is impossible to accept higher dose in the following reception.

Influence on ability to driving of motor transport and to control of mechanisms
Drug Antisten of MV has no significant effect on ability to manage motor transport and to perform other works demanding the high speed of psychomotor reactions.

Side effects:

Frequency: very often - more than 1/10; often - more than 1/100 and less than 1/10; infrequently - more than 1/1000 and less than 1/100; seldom - more than 1/10000 and less than 1/1000; very seldom - less than 1/10000, including separate messages.

- From the alimentary system: often - an abdominal pain, diarrhea, dyspepsia, nausea, vomiting.
- From cardiovascular system: seldom - orthostatic hypotension, "inflows" to face skin.
- From the central nervous system: dizziness, a headache is frequent; very seldom - extrapyramidal frustration (a tremor, rigidity, an akineziya), reversible after drug withdrawal.
- From integuments and a hypodermic fatty tissue: often - skin rash, an itch, a small tortoiseshell.
- Other: often - an adynamy.

Interaction with other medicines:

There are no data on medicinal interaction of drug.

Contraindications:

• hypersensitivity to any component of drug;
• renal failure (KK less than 15 ml/min.);
• the expressed abnormal liver functions; ■возраст up to 18 years (efficiency and safety are not established.

USE AT PREGNANCY AND IN THE PERIOD OF THE LACTATION
Researches on animals did not reveal teratogenic effect, however, due to the lack of clinical data on safety of use of drug during pregnancy, the risk of developing of malformations of a fruit cannot be excluded.
Use of drug at pregnancy is contraindicated.
It is unknown whether it is allocated MB ANTI-WALLS with breast milk. In need of use of drug of ANTI-WALLS of MB in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination.

Overdose:

Now about cases of overdose of drug it was not reported.

Storage conditions:

To store in the dry, protected from light place at a temperature not above 25 °C.
To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Tablets of the prolonged action, film coated 35 mg
On 10, 20, 30 tablets place in a blister strip packaging from a film of the polyvinyl chloride and printing aluminum foil varnished.
On 10, 20, 30, 40, 50, 60 or 100 tablets place in a container polymeric for medicines. One container or 1, 2, 3, 4, 5, 6 or 10 blister strip packagings together with the application instruction place in a pack from a cardboard.