Piracetam solution

General characteristics. Structure:

1 ml of solution contains mg piracetam 200;
excipients: sodium acetic-3 water, the acetic acid divorced water for injections.

Pharmacological properties:

Pharmacodynamics. Piracetam strengthens dopamine synthesis in a brain, raises noradrenaline contents. Drug also increases quantity of acetylcholine at the synoptic level and density of holinoretseptor. It is impossible to exclude GAMK-from effect of drug ergichesky elements in spite of the fact that it does not turn into GAMK. Drug positively influences processes of exchange and blood circulation of a brain, stimulates oxidation-reduction processes, increases glucose utilization, improves
the regional blood stream in ischemic sites of a brain, increases energy potential of an organism with the participation of ATP and adenylatecyclase. Optimization of power processes promotes increase in resistance of TsNS to a hypoxia and various toxic factors. Piracetam improves integrative activity of a brain, promotes memory consolidation, improves training processes.

Pharmacokinetics. At introduction to an organism gets into different bodies and fabrics including in brain tissue. Practically it is not metabolized. It is removed by kidneys. The elimination half-life makes about 4 h; out of cerebrospinal fluid it is brought much more slowly that testifies to high tropism of drug to brain fabric.

Indications to use:

Drug is appointed at brain atherosclerosis, a vascular prkinsonizm, other pathological processes with the phenomena of chronic cerebral vascular insufficiency with disturbance of memory, attention, the speech, dizziness, at changes of cerebral circulation, coma and subcomas as a result of injuries of a brain and intoxications. Apply at diseases of a nervous system with decrease in intelektualno-mnestichesky functions and disturbances of the emotional and strong-willed sphere. In psychiatric practice apply at neurotic and astenoadinamichesky depressions with advantage of signs of an adynamia, asthenic, senesto-hypochiondrial disturbances, ideatony block, at vyaloapatichesky defective states, at schizophrenia, at psychoorganic syndromes of various etiology, senile and atrophic processes, in complex therapy of mental diseases. Appoint in complex therapy of senile dementias, including Alzheimer's disease. In pediatrics Piracetam is applied at tserebrostenichesky, encephalopathic disturbances. Piracetam is used for acute management at abstinent, predeliriozny and delirious states at alcoholism, drug addiction, in case of an acute alcoholic poisoning, morphine, barbiturates. At an alcoholism Piracetam is appointed for reduction of the phenomena of an adynamy, intelektualno-mnestichesky and other disturbances of mental activity. It is reasonable to use drug at acute virus neyroinfekiya for reduction of ischemia and a hypoxia of a brain. Anti-hypoxemic influence of drug should be considered in complex therapy of a myocardial infarction.

Route of administration and doses:

In case of comas, heavy cerebral processes, for acute management at abstinence, at heavy intoxications, deliriums the drug is administered intramusculary or in a vein, since 2 - 4 g and quickly bringing a dose to 4 - 6 g a day. After improvement of a state pass to use inside.

Features of use:

It is necessary to control constantly indicators of function of kidneys (especially at patients with a chronic renal failure) - residual nitrogen and creatine, and patients with diseases of a liver have a functional condition of a liver. It is necessary to avoid sharp drug withdrawal. At the patients receiving antiepileptic medicines during therapy by Piracetam the main therapy as the threshold of convulsive readiness can decrease has to continue surely. In case of developing of sleep disorders it is recommended to cancel evening administration of drug, having attached this dose to day reception. Gets through the filtering membranes of devices for a hemodialysis.

Side effects:

Piracetam, as a rule, is well transferred as a result of practical non-toxicity. At some patients the acrimony, concern, a sleep disorder, the dispeptic phenomena are possible, elderly patients can have a sharpening of coronary insufficiency (it is necessary to reduce a dose or to cancel drug). Allergic reactions, manifestations of individual intolerance are possible.

Interaction with other medicines:

Use of Piracetam can be combined with psychotropic, cardiovascular and many other drugs. There are data on strengthening by drug of effect of antidepressants and anti-anginal drugs.

Contraindications:

Acute renal failure, do not appoint to children, sick diabetes and with existence in the anamnesis of data on the allergic reactions connected with the use of fruit juice, essences. Children are also not recommended to appoint drug till 1 year.

Overdose:

At overdose irritability, sleeplessness, a tremor are possible; elderly patients have an exacerbation of heart failure. In this case it is necessary to reduce a drug dose.

Storage conditions:

To store in the unavailable to children, protected from light place at a temperature of 15 - 25 °C. A period of validity – 3 years.

Issue conditions:

According to the recipe

Packaging:

On 5 ml of solution in ampoules No. 10.