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Xylomethazolinum

Препарат Ксилометазолин. ООО "Випс-Мед" Россия


Producer: LLC Vips-Med Russia

Code of automatic telephone exchange: R01AA07

Release form: Liquid dosage forms. Drops. Spray nasal.

Indications to use: Rhinitis (cold). Allergic rhinitis (cold). Sinusitis. Pollinosis. Average otitis. Rinoskopiya.


General characteristics. Structure:

Active ingredient: 0,5 mg or 1 mg of xylomethazolinum (in the form of a hydrochloride) in 1 ml of solution.

Excipients: a benzalkoniya chloride, dinatrium эдетат (Trilonum of B), potassium dihydrophosphate (potassium phosphate monosubstituted), hydrophosphate sodium dodecahydrate (sodium phosphate disubstituted), sodium chloride, the water purified.




Pharmacological properties:

Pharmacodynamics. Xylomethazolinum concerns to group of local vasoconstrictors (decongestants) with an alpha adrenomimeticheskoy activity, causes narrowing of blood vessels of a mucous membrane of a nose, eliminating, thus, hypostasis and a hyperemia of a mucous membrane of a nose, recovers passability of the nasal courses, facilitates nasal breath.

Effect of drug comes in a few minutes after its use and continues till 10 o'clock.

Pharmacokinetics. At topical administration drug is practically not absorbed therefore its concentration in a blood plasma are very small (by modern analytical methods are not defined).


Indications to use:

Acute respiratory diseases with the phenomena of rhinitis (cold); acute allergic rhinitis, sinusitis, pollinosis; average otitis (as a part of a combination therapy for reduction of hypostasis of a mucous nasopharynx); training of the patient for diagnostic manipulations (rinoskopiya).


Route of administration and doses:

Intranazalno. To adults and children 6 years on 1 injection of 0,1% of solution of xylomethazolinum in each nasal course 2-3 times a day are more senior.

To children aged from 2 up to 6 years apply 0,05% xylomethazolinum solution on 1 injection in each nasal course 1-2 times a day.

It is not necessary to use drug more often than 3 times a day. Not to use drug without interruption more than 3-5 days.


Features of use:

Pregnancy and lactation: contraindicated.

Before use it is necessary to clear the nasal courses.

It is not necessary to apply for a long time, for example, at chronic rhinitis.

Influence on ability to manage vehicles and mechanisms: it is not described


Side effects:

At frequent and/or prolonged use - irritation and/or dryness of a mucous membrane of a nasopharynx, burning, paresthesias, sneezing, hypersecretion; seldom - a rhinedema, heartbeat, tachycardia, arrhythmia, increase in arterial pressure, vomiting, a headache, sleeplessness, a vision disorder, a depression (at prolonged use of high doses).


Interaction with other medicines:

It is incompatible with MAO inhibitors and tricyclic antidepressants.


Contraindications:

Hypersensitivity to xylomethazolinum, arterial hypertension, tachycardia, the expressed atherosclerosis, glaucoma, atrophic rhinitis, a thyrotoxicosis, surgical interventions on a meninx (in the anamnesis), children's age up to 2 years for use of 0,05% of solution and up to 6 years - for 0,1% of solution.

Not to apply at therapy by inhibitors of monoamine of a ksidaza (MAO) and tricyclic antidepressants.

With care: coronary heart disease (stenocardia III-IV functional class), prostate hyperplasia, diabetes mellitus, pregnancy, lactation period.


Overdose:

Symptoms: strengthening of side effects.


Storage conditions:

At a temperature from 0 to 25 °C in the dry, protected from light place. To store in the place, unavailable to children. A period of validity - 3 years. Not to apply after a period of validity.


Issue conditions:

According to the recipe


Packaging:

Spray of nasal 0,05%, 0,1%. On 10, 20 ml in the bottles of neutral glass corked by the blooming microsprayer, a raspylitelny nozzle and a protective cap. One bottle in a pack from a cardboard bandbox.



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