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medicalmeds.eu Medicines Expectorant mucolytic means. Бронхобос capsules

Бронхобос capsules

Препарат Бронхобос капсулы. Bosnalijek (Босналек) Республика Босния-Герцеговина


Producer: Bosnalijek (Bosnalek) Republic Bosnia-Herzegovina

Code of automatic telephone exchange: R05CB03

Release form: Firm dosage forms. Capsules.

Indications to use: Tracheitis. Bronchitis. Tracheobronchitis. Bronchial asthma. Bronchoectatic disease. Rhinitis (cold). Average otitis. Sinusitis. Bronkhoskopiya. Bronchography.


General characteristics. Structure:

1 capsule contains:
Active ingredient: карбоцистеин 375,0 mg
Excipients: starch corn – 23,00 mg, magnesium stearate – 2,00 mg, gelatin – 8,00 mg, silicon dioxide colloid – 2,00 mg.

Description. The solid gelatin opaque capsules of yellow color No. 0 filled with powder of white color.




Pharmacological properties:

Pharmacodynamics. Mucolytic and expectorant action is caused by activation of sialine transferase – enzyme of scyphoid cells of a mucous membrane of bronchial tubes. Normalizes a quantitative ratio of acid and neutral sialomutsin of a bronchial secret. Reduces viscosity of a bronchial secret and the nose separated from adnexal bosoms, facilitates otkhozhdeny phlegms and slime, reduces cough. Promotes regeneration of a mucous membrane, normalizes its structure, stirs up activity of a ciliate epithelium. Recovers IgA immunoglobulin secretion (specific protection) and the number of sulphhydryl groups of components of slime (nonspecific protection), improves mukotsiliarny clearance.

Pharmacokinetics. Karbotsistein is quickly soaked up after intake. Bioavailability – low (less than 10% of the accepted dose). The maximum concentration in blood serum and in a mucous membrane of respiratory tracts is reached in 2-3 hours after administration of drug inside and remains in a mucous membrane within 8 hours. It is metabolized in a liver (has effect of "the first passing" through a liver). It is removed preferential by kidneys, partially in not changed look, partially in the form of metabolites. Elimination half-life about 2 hours.


Indications to use:

The acute and chronic bronchopulmonary diseases which are followed by education by knitting, the hardly separated phlegm (tracheitis, bronchitis, a tracheobronchitis, bronchial asthma, a bronchoectatic disease) and slime (inflammatory diseases of a middle ear, nose and its adnexal bosoms – rhinitis, average otitis, sinusitis), preparation for a bronkhoskopiya and/or bronchography.


Route of administration and doses:

For intake.
To adults and teenagers 15 years are more senior: 750 mg (2 capsules) three times a day. After achievement of therapeutic effect the daily dose is reduced to 1,5 g: on 750 mg (2 capsules) twice a day. Treatment should not continue more than 8-10 days without consultation with the doctor.


Features of use:

At patients with a peptic ulcer of a stomach and duodenum in the anamnesis the dose of drug has to be lowered. Treatment can be combined with physiotherapeutic procedures.
Influence of drug on ability to manage vehicles and the work demanding the increased concentration of attention and speed of psychomotor reactions it was not studied.


Side effects:

From digestive tract: nausea, vomiting, diarrhea, pain in epigastriums, gastrointestinal bleeding is sometimes noted.
Allergic reactions: skin itch, small tortoiseshell, dieback, Quincke's disease.
Others: dizziness, weakness, indisposition.


Interaction with other medicines:

Karbotsistein increases efficiency of glucocorticosteroid and antibacterial therapy of inflammatory diseases of upper and lower respiratory tracts, potentsiirut broncholitic effect of theophylline. Activity of a karbotsistein is weakened by antibechic and atropinopodobny means.


Contraindications:

Hypersensitivity to a karbotsistein or other components of drug, a peptic ulcer of a stomach and duodenum in aggravation stages, a chronic glomerulonephritis (in an aggravation phase), cystitis, children's age up to 15 years, pregnancy (the I trimester).

With care: at administration of drug at a chronic glomerulonephritis (in the anamnesis), a peptic ulcer of a stomach and a duodenum (in the anamnesis), at pregnancy (the II-III trimesters) and during feeding by a breast.

Use at pregnancy and in the period of a lactation
In II and III trimesters of pregnancy drug is appointed only in that case when the estimated advantage for mother exceeds potential risk for a fruit. In need of purpose of drug in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination.


Overdose:

Symptoms: gastralgia, nausea, diarrhea.
Treatment: symptomatic.


Storage conditions:

It is not necessary to use medicine after the period of validity specified on packaging! At a temperature from 15 to 30 °C, in the place, unavailable to children. A period of validity - 3 years.


Issue conditions:

Without recipe


Packaging:

Capsules on 375 mg. On 10 capsules in the PVC blister / it is scarlet. On 3 blisters with the application instruction in a cardboard pack.



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