Ambroksol-Vishfa

General characteristics. Structure:

Active ingredient: 5 ml of syrup contain Ambroxol of a hydrochloride 15 mg.
Excipients: propylene glycol, methylparahydroxybenzoate (Е 216), пропилпарагидроксибензоат (Е 218), ethanol of 96%, sorbite (Е 420), Strawberries Aroma fragrance (supports E 124), the water purified.

Transparent siropoobrazny liquid of pink color, with a characteristic smell, sweet taste.

Pharmacological properties:

Drug has sekretolitichesky, sekretomotorny effect. Stimulates serous cells of glands of a mucous membrane of bronchial tubes that leads to increase in secretion of slime and change of a ratio of serous and mucous components of a phlegm. Besides activation of the hydrolyzing enzymes and increase in a physical activity of a ciliary epithelium of bronchial tubes promotes improvement of department of a pathological secret from walls of bronchial tubes and its conclusion from respiratory tracts. Drug increases the content of surfactant in lungs, prevents its destruction in pnevmotsita that also promotes improvement of drainage function of lungs. The pharmacological effect of drug does not change at children, patients of old age, at disturbance of functions of digestive tract, liver, kidneys, cardiovascular system.

At oral administration Ambroxol is almost completely absorbed in digestive tract, quickly distributed in body tissues, the highest concentration is defined in lungs. Drug gets through hematoencephalic and placental barriers, is emitted in breast milk. Effect of drug begins in 30 min. and lasts for 6–12 h.

It is metabolized in a liver by conjugation with formation of inactive metabolites. It is removed preferential by kidneys. The elimination half-life makes 8–10 h.

Indications to use:

Acute and chronic respiratory diseases which are followed by allocation of the knitting phlegm and dry cough: tracheitis, bronchitis, bronchoectatic disease, pneumonia, bronchial asthma. Diseases of ENT organs which are followed by formation of dense slime: laryngitis, pharyngitis, sinusitis, rhinitis.

Route of administration and doses:

Internally — to adults and teenagers 12 years in the first 2–3 days on 10 ml (30 mg) three times a day, further — 10 ml (30 mg) twice or on 5 ml three times a day are more senior.

To children aged from 3 up to 5 years — on 2.5 ml (7,5 mg) of syrup to bring syrup volume warm boiled water to a tag of a measured glass of 15 ml, three times a day.

To children aged from 6 up to 12 years — on 5 ml (15 mg) twice or three times a day.

Duration of a course of treatment makes 14 days.

Features of use:

Drug is used after meal.

Because of existence in composition of sorbite drug can cause insignificant laxative action.

Use during pregnancy or feeding by a breast. In ІІ-ІІІ a trimester of pregnancy apply taking into account preliminary definition by the doctor of a ratio advantage for woman/risk to a fruit (child). For treatment to stop feeding by a breast.

Ability to influence speed of response at control of motor transport or other mechanisms. Drug does not influence speed of response at control of motor transport or other mechanisms.

Children. 1 ml of drug contains from 2% to 3% of ethanol therefore   to children under 6 years the dose of drug gets divorced warm boiled water.

Side effects:

Allergic reactions (skin rash, small tortoiseshell, Quincke's disease). The dispeptic phenomena (pain in the epigastric site, a diarrhea, nausea, vomiting), a dysuria, a rhinorrhea can sometimes be observed.

 

Interaction with other medicines:

 It is not recommended to accept along with antibechics. It can lead to difficulty of an otkhozhdeniye of a phlegm from bronchial tubes against the background of reduction of cough. Drug increases efficiency of antibiotics (ampicillin, amoxicillin, a tsefuroksim, a doksitsilin).

Contraindications:

The first trimester of pregnancy, the feeding period a breast, a peptic ulcer of a stomach and duodenum, a spastic syndrome, hypersensitivity to drug components. Children's age up to 3 years.

Overdose:

Can cause a digestive disturbance which is shown in the form of pains in epigastric area, nausea, vomiting. Therapy is symptomatic.

Storage conditions:

To store at  a temperature not above 25 °C in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

On 100 ml in bank or a bottle with the dosing glass in a pack.