Амбро®

General characteristics. Structure:

Active agent - Ambroxol a hydrochloride (in terms of 100% substance) 15.0 mg.

Excipients: citric acid monohydrate, sodium chloride, sodium hydrophosphate heptahydrate, acid chlorohydrogen 1M solution, water for injections.

Pharmacological properties:

Pharmacokinetics. Ambroxol absorption bystry and rather full, with linear dependence in the therapeutic range. The maximum concentration of active ingredient in a blood plasma is reached in 30 minutes – 3 hours. In a blood plasma about 90% of drug contacts proteins. Distribution of Ambroxol between blood and fabrics happens quickly, high concentration of active agents in lungs is observed. Plasma elimination half-life makes 7-12 hours; accumulation in fabrics is not revealed. Ambroxol is metabolized generally in a liver by conjugation. It is removed by kidneys: 90% in the form of water-soluble metabolites, in not changed look - 5%. T1/2 increases at heavy HPN, does not change at an abnormal liver function.

Pharmacodynamics. Амбро® - mucolytic drug. Possesses sekretomotorny, sekretolitichesky and expectorant action; stimulates serous cells of glands of a mucous membrane of bronchial tubes, increases the maintenance of a mucous secret and release of surfactant (surfactant) in alveoluses and bronchial tubes; normalizes the broken ratio of serous and mucous components of a phlegm. Activating the hydrolyzing enzymes and strengthening release of lysosomes from cells Klara, reduces viscosity of a phlegm. Increases physical activity of a ciliary epithelium, increases mukotsiliarny transport.

Indications to use:

- acute and chronic bronchitis;

- pneumonia;

- chronic obstructive pulmonary disease;

- bronchial asthma with the complicated phlegm otkhozhdeniye;

- bronchoectatic disease;

- mucoviscidosis;

- treatment respiratory a distress syndrome at premature and newborn children (as a part of complex therapy).

Route of administration and doses:

Solution for injections is entered intramusculary, intravenously (slowly struyno or kapelno). For in/in drop introductions of 50 ml part in 500 ml of infusion solution (as solvent apply 0.9% NaCl solution, 5% dextrose solution. Enter during 2 h with a speed of 84 of cap/min. Repeated treatment according to the provided scheme can be carried out in 14 days (when saving indications).

The adult appoint 15-30 mg (1-2 ampoules) 2-3 times a day, in hard cases – on 30 mg 2-3 times a day.

To children under 2 years enter 7,5 mg (1/2 ampoules) 2 times.

To children from 2 to 5 years – on 7,5 mg (1/2 ampoules) 3 times a day, are more senior than 5 years – on 15 mg (1 ampoule) 2-3 times a day.

At respiratory the distress syndrome at premature children and newborns a daily dose of Ambro is increased to 10 mg/kg (in hard cases – to 30 mg/kg), distributing on 3-4 introductions.

Parenteral administration stops after disappearance of acute displays of a disease (pass to intake or rectal administration).

It is not recommended to apply without medical appointment more than within 4-5 days.

Features of use:

With care appoint at an abnormal liver function or kidneys, motor dysfunction of bronchial tubes or at allocation of a large number of a secret (because of slime accumulation threat). At heavy abnormal liver functions and kidneys it is necessary to reduce a dosage or to increase intervals between receptions.

Pregnancy and period of a lactation. In II and the III trimester of pregnancy use is possible if the expected effect of therapy exceeds potential risk for a fruit.

Features of influence of medicine on ability to manage motor transport and potentially dangerous mechanisms. Considering side effects of medicine it is necessary to be careful at control of motor transport or potentially dangerous mechanisms.

Side effects:

At bystry intravenous administration:

- feeling of catalepsy, adynamia, intensive headaches, lowering of arterial pressure, short wind, hyperthermia, fever.

Seldom:

- allergic reactions (skin rash, a small tortoiseshell, a Quincke's disease breath disturbance, temperature reaction with a fever);

- diarrhea, dryness of a mucous membrane of an oral cavity and respiratory tracts, dieback, rhinorrhea, locks, dysuria. At prolonged use in high doses - a gastralgia, nausea, vomiting.

In some cases:

- heavy reactions of anaphylactic type are possible.

Interaction with other medicines:

Simultaneous use of drug with the medicines having antibechic activity (for example, containing codeine) because of difficulty of removal of a phlegm from bronchial tubes against the background of reduction of cough is not recommended. Simultaneous use of Ambroxol with antibiotics (amoxicillin, tsefuroksy, erythromycin, doxycycline and others) improves receipt of antibiotics in pulmonary ways that can reduce treatment terms.

Ambro's solution for injections is incompatible in one syringe or a dropper with other medicines, value рН whom it exceeds 6,3 as has acid properties.

Contraindications:

- hypersensitivity to Ambroxol and/or other components of drug;

- peptic ulcer of a stomach and duodenum;

- I trimester of pregnancy and period of a lactation;

- a fenilketonuriya (for the dosage forms containing aspartame).

Overdose:

Symptoms - strengthening of side effects.

Treatment – symptomatic.

Storage conditions:

To store in the dry, protected from light place, at a temperature not above 30 °C.

To store in the place, unavailable to children!

Issue conditions:

According to the recipe

Packaging:

On 2 ml in ampoules.

On 5 ampoules pack into a blister strip packaging from a film polyvinyl chloride and a foil alyyuminiyevy.

2 planimetric packagings together with the approved instruction on a medical use in the state and Russian languages place in a pack from a cardboard.