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medicalmeds.eu Medicines The means operating on respiratory system. Ambrotard 75

Ambrotard 75

Препарат Амбротард 75 . ХФЗ ЗАО НПЦ Борщаговский Украина


Producer: HFZ CJSC NPTs Borshchagovsky Ukraina

Code of automatic telephone exchange: R05CB06

Release form: Firm dosage forms. Capsules.

Indications to use: Bronchitis. Mucoviscidosis of lungs. Bronkhoskopiya. Bronchial asthma. Pneumonia. Bronchoectatic disease.


General characteristics. Structure:

International and chemical names: ambroxol; trans-4-[(2-amino-3,5-dibrombenzil) amines] cyclohexanol hydrochloride;
main physical and chemical properties: solid capsules with a transparent lid of greenish-blue color and the transparent colourless case which contain pellets of creamy-white color;
structure: 1 capsule contains hydrochloride Ambroxol in the form of pellets with the prolonged release in recalculation on Ambroxol a hydrochloride – 75 mg;




Pharmacological properties:

Pharmacodynamics. Ambroxol a hydrochloride – synthetic sekretolitichesky and sekretomotorny means from group of benzylamines, stimulates serous cells of glands of a mucous membrane of bronchial tubes that leads to increase in secretion of slime and change of a ratio of serous and mucous components of a phlegm. It, and also activation of hydrolytic enzymes and increase in a physical activity of a ciliary epithelium of bronchial tubes promotes improvement of department of a pathological secret from walls of bronchial tubes and its removal from respiratory tracts. Ambroxol increases the content of surfactant in lungs, and also prevents its destruction in pnevmotsita that also promotes improvement of drainage function of lungs. Ambroxol well gets through a placental barrier and stimulates pre-natal synthesis of surfactant in fruit lungs. Ambroxol is non-toxic drug, does not kumulirutsya and does not show mutagen and teratogenic properties. The pharmacological effect of drug does not change at children, elderly patients, and also at disturbance of functions of digestive tract, liver, kidneys, cardiovascular system.

Pharmacokinetics. At oral administration of drug Ambroxol is gradually released from capsular weight and completely soaked up, well gets into tissues of lungs. The maximum concentration of Ambroxol in a blood plasma is observed in 9 hours after oral administration. It is metabolized in a liver. 90% are removed with urine in the form of metabolites.


Indications to use:

Acute and chronic bronchitis; bronchoectatic disease; pneumonia; bronchial asthma; for prevention and treatment of complications after lung operations; before and after a bronkhoskopiya; at a mucoviscidosis of lungs.


Route of administration and doses:

To adults and children 12 years are more senior appoint inside on 1 capsule a day in the morning after food. The course of treatment makes from 4 to 14 days depending on weight of a course of a disease.


Features of use:

At purpose of drug during feeding it is necessary to resolve by a breast an issue of the breastfeeding termination.


Side effects:

Allergic reactions in the form of skin rashes, a small tortoiseshell, a Quincke's disease are possible. At long use in high doses pain in epigastric area, nausea, vomiting can be observed.


Interaction with other medicines:

Drug interaction Ambrotard 75 with:
– antibiotics. At simultaneous use with antibiotics concentration of the last in pulmonary fabric and a phlegm increases;
– β-adrenoblockers.......... Simultaneous use not of cardioselective β-adrenoblockers ((((((((((especially) can worsen otkhozhdeny phlegms owing to a bronchospasm;
– β-adrenomimetikam. Use of the selection β2–адреномиметиков and Ambroxol reduces manifestation of a bronkhoobstruktion, improves bronchial conductivity;
– M-holinoblokatorami. Use M-holinoblokatorov (behind exception M1-holinoblokatorov) reduces Ambrotard's efficiency 75 by a hypomyxia bronchial glands and increases in viscosity of a phlegm;
– M-cholinomimetics. At simultaneous use slime hypersecretion is possible. At a reduced tussive reflex obstruction of bronchial tubes slime is possible that it can demand active aspiration of slime from a bronchial tree;
– methylxanthine derivatives. Simultaneous use of drugs promotes increase in department and improvement of expectoration;
– the drugs oppressing a tussive reflex. Simultaneous use of drugs can lead to obstruction of bronchial tubes slime that can demand active aspiration of slime from a bronchial tree.


Contraindications:

Hypersensitivity to Ambroxol. First trimester of pregnancy, peptic ulcer of a stomach and duodenum.
Ambrotard's use 75 for treatment of children is not recommended 12 years are younger.


Overdose:

Hypersensitivity to Ambroxol. First trimester of pregnancy, peptic ulcer of a stomach and duodenum.
Ambrotard's use 75 for treatment of children is not recommended 12 years are younger.


Storage conditions:

To store in dry, protected from light, the place, unavailable to children, at a temperature not above 25 °C. A period of validity - 2 years.


Issue conditions:

Without recipe


Packaging:

On 10 capsules in a blister strip packaging, on 1 blister strip packaging in a pack.



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