Platyphyllinum hydrotartrate
Producer: JSC Himfarm Republic of Kazakhstan
Code of automatic telephone exchange: A03AX
Release form: Liquid dosage forms. Solution for injections.
General characteristics. Structure:
Active agent - Platyphyllinum hydrotartrate in terms of 100% substance of 2,0 mg.
Excipient - water for injections to 1,0 ml.
Pharmacological properties:
Pharmacokinetics. Platyphyllinum after parenteral administration quickly and easily gets through gistogematichesky barriers (including hematoencephalic), cellular and synaptic membranes. At introduction of high doses (above therapeutic) collects in tissues of the central nervous system in significant concentration. It is metabolized in a liver. It Eliminirutsya by kidneys and intestines. At the correct appointment (doses, intervals between receptions) does not kumulirut.
Pharmacodynamics. Drug has spasmolytic, vasodilating, sedative effect. Blocks m-holinoretseptory and exerts the direct running-down impact on unstriated muscles. Has direct myotropic spasmolytic effect, causes expansion of small vessels. In high doses the vasomotor center oppresses and blocks sympathetic a ganglion owing to what vessels extend, and the ABP (decreases mainly at intravenous administration). More weakly than atropine oppresses secretion of hemadens; causes the expressed decrease in a tone of unstriated muscles, amplitudes and frequencies of peristaltic reductions of a stomach, a duodenum, a small and large intestine, moderate decrease in a tone of a gall bladder (in persons with a hyperkinesia of biliary tract); at a hypokinesia - the tone of a gall bladder raises before normal contents. Causes relaxation of smooth muscles, bladder and urinary tract, having spasmolytic effect, eliminates a pain syndrome. Excites a brain and a respiratory center, more - a spinal cord (in high doses spasms, oppression of TsNS, the vasomotor and respiratory centers are possible). Gets through GEB.
Indications to use:
- spasms of unstriated muscles at a peptic ulcer of a stomach and duodenum
- at intestinal, hepatic and renal gripes
- brain vasospasms
- a pain syndrome at pancreatitis
- pancreatic coma
- dyskinesia of biliary tract
- bradyarrhythmias
- poisonings with acetone, boric acid, strong acids, arsenic, Reserpinum (in complex therapy)
- diarrhea (in complex therapy).
Route of administration and doses:
Subcutaneously, for stopping of kolikoobrazny, abdominal pain, a prolonged attack of bronchial asthma, cerebral and peripheral vasomotor spasms of 1-2 ml of 0,2% of solution 1-2 times a day (for vasodilatation and a lowering of arterial pressure intravenous administration is shown).
The doctor establishes a course of treatment individually depending on indications of a disease and age of the patient.
Features of use:
With care apply at diseases of cardiovascular system at which increase in heart rate is undesirable (acute bleeding, a ciliary arrhythmia, tachycardia, etc.), at a thyrotoxicosis (strengthening of tachycardia is possible), at the increased body temperature (its further increase owing to suppression of activity of sweat glands is possible), achalasias of a gullet and a pyloric stenosis (the possible decrease in motility and a tone resulting in impassability and a delay of contents of a stomach), an intestines atony at patients of advanced age or the weakened patients, closed-angle and okrytougolny glaucoma, toxicosis of pregnant women, injury of a brain at children.
It is necessary to abstain from potentially dangerous types of activity requiring special attention.
Side effects:
- dryness in a mouth, thirst
- expansion of pupils, increase in intraocular pressure
- lowering of arterial pressure
- heartbeat
- accommodation disturbance
- otdyshka
- difficulty of an urination
- excitement
- spasms
- photophobia
- lung atelectasis
Interaction with other medicines:
Increases duration of somnolent effect of phenobarbital and an etaminal of sodium, blocks effects of a prozerin, raises — appointed in H2-gistaminolitikov, digoxin and Riboflavinum (slows down a peristaltics and improves absorption). Adrenomimetiki (strengthen a mydriasis) and nitrates exponentiate increase in intraocular pressure, amizyl, дифенгидрамин, tricyclic antidepressants, quinidine sulfate, новокаинамид, Disopyramidum, an isoniazid, MAO inhibitors, Midantanum — anticholinergic activity. Eliminates the bradycardia, nausea and vomiting caused by morphine, bradycardia at verapamil reception.
Contraindications:
- the increased individual sensitivity to Platyphyllinum
- a cerebral palsy at children
- glaucoma
- liver and/or renal failure
- paralytic impassability or atony of intestines
- ulcer colitis
- chronic diseases of lungs
- a vegetative neuropathy, a prostatauxe without obstruction of urinary tract
- gestosis
- pregnancy, lactation period
- Down syndrome
- advanced and senile age
- children's age up to 15 years
- a piloroduodenalny stenosis, a reflux esophagitis, phrenic hernia in combination with a reflux-ezofagititom
Overdose:
Symptoms: dryness in a mouth, hoarseness of a voice, swallowing disturbance, expansion of pupils with lack of a photoharmose, tachycardia, a hyperthermia, erubescence, excitement of TsNS with the subsequent oppression, disturbance of consciousness, a hallucination, a convulsive syndrome, respiratory insufficiency, intestines paresis, an acute ischuria.
Treatment: gastric lavage; administration of the inhibitors of cholinesterase (physostigmine, Galantaminum or a prozerin) weakening paresis of intestines and umenshshayushchy tachycardia; at moderate excitement and not expressed spasms administration of magnesium of sulfate, in hard cases – sodium hydroxybutyrate, an oxygenotherapy, artificial ventilation of the lungs is recommended.
Storage conditions:
To store in the dry, protected from light place, at a temperature not over 30 ºС.
To store in the place, unavailable to children!
Issue conditions:
According to the recipe
Packaging:
On 1 ml in ampoules of neutral glass, on 10 ampoules place in a box from a cardboard, on 5 ampoules pack into a blister strip packaging. Boxes or planimetric packagings place in a box from a cardboard, put the application instruction in group packaging in the state and Russian languages.
