Gelarium Giperikum

General characteristics. Structure:

Active ingredients: 285 mg of the St. John's Wort which is made a hole herbs extract dry
(4,5 - 6,7: 1; extragent ethanol 60%).

Excipients: silicon dioxide colloid, potato starch, lactose, magnesium stearate.

Structure of a cover of a dragee: shellac, talc, calcium carbonate, titanium dioxide (Е 171), sucrose, kaolin, Arabian gum, macrogoal, quinoline yellow (Е 104), green lakoobrazuyushchy means (Е 104/E132).

Pharmacological properties:

Pharmacodynamics. Means of a plant origin. Renders antidepressive and anxiolytic (reduces alarm, tension, increases mood) action.

Indications to use:

Psychovegetative frustration (decrease in mood, apathy), neurotic reactions. Depressions easy and moderately severe.

Route of administration and doses:

Inside, to adults and children 12 years on 1 dragee 3 times a day are more senior during food. The dragee should swallow without chewing, if necessary washing down with water. It is necessary to accept drug not less than 4 weeks. If symptoms remain more than 4 weeks, then it is necessary to consult with the doctor.

Features of use:

Drug can be appointed a sick diabetes mellitus as one dragee contains less than 0,03 considered "grain units" (GU).

During treatment it is necessary to refrain from the use of etanolsoderzhashchy drinks and within 1-2 weeks to avoid ultraviolet radiation (including a sunbed, UF-lamps, long stay on solar to light).

Influence of medicine on ability to manage vehicles, to work with moving mechanisms. Drug does not exert impact on ability to performance of potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions (including, control of vehicles, work with moving mechanisms).

Side effects:

Allergic reactions are possible: a skin itch, rash, eczema, a xanthopathy, a photosensitization (is more often at HIV-positive patients), increase in a sensitization to hair of animals.

From the central nervous system: concern, excessive fatigue, headache.

From the alimentary system: nausea, an abdominal pain (including in epigastric area), dryness of a mucous membrane of an oral cavity, a meteorism, diarrhea or a lock, anorexia.

From bodies of a hemopoiesis: iron deficiency anemia.

Interaction with other medicines:

Reduces efficiency of indirect anticoagulants (a fenprokumon, warfarin), an imatinib and other tsitostatik, midazolam, digoxin, amitriptyline, a feksofenadin, benzodiazepines, a nortriptilin, theophylline, methadone, verapamil, a simvastatin, a finasterid.

At a concomitant use with some antidepressants, such as нефазодон, пароксетин, sertraline, буспирон, triptanes strengthening of their action is possible (at the same time such symptoms as nausea, vomiting, fear, concern, confusion of consciousness can appear).

Drug is capable to strengthen the photosensitizing effect of some other medicines: tetracyclines, streptocides, thiazide diuretics, hinolon, piroxicam.

Extends the dream caused by medicines for the general anesthesia and narcotic analgetics, but shortens the dream caused by barbiturates.

Reduces hypotensive effect of Reserpinum. Reduces concentration of cyclosporine in blood.

The St. John's Wort which is made a hole reduces concentration in blood and efficiency of therapy indinaviry.

At simultaneous use with ethinylestradiol also dezogestrelemvozrastat risk of development of bleeding of "break".

Increases theophylline metabolism speed. Reducing concentration in digoxin blood, reduces its efficiency.

The women accepting oral contraceptives during treatment by drug should use additional methods of contraception.

Contraindications:

Individual hypersensitivity to drug components, children's age up to 12 years (because of insufficiency of clinical data).

Insufficiency of lactase, lactose intolerance, glyukozo-galaktozny malabsorption, deficit of invertase/isomaltase, intolerance of fructose.

Existence of a photosensitization (hypersensitivity) of skin to ultraviolet radiation. Simultaneous use with cyclosporine, takrolimusy (for system use), amprenaviry, indinaviry and other inhibitors of protease (at treatment of HIV-positive patients), and also with irinotekany and warfarin; with monoamine oxidase inhibitors (the interval between reception has to be not less than 14 days).

Overdose:

At overdose strengthening of dozozavisimy side effects is possible.

Treatment: symptomatic; besides, patients should avoid within 1-2 weeks a sunlight or ultraviolet radiation.

Storage conditions:

In the dry, protected from light place, at a temperature not above 25 °C. To store in unavailable to children in the place. Period of validity 3 years. Not to use after the period of validity specified on packaging.

Issue conditions:

Without recipe

Packaging:

Dragee. On 15, 20 or 25 dragees in the blister from aluminum foil (lower part) and polyvinylchloride / a polyvinylidene chloride film (an upper part). On 2 (on 15 dragees), 3 (on 20 dragees) or 4 (on 25 dragees) the blister together with the application instruction place in a folding cardboard box.