Дипросалик®

General characteristics. Structure:

Active ingredient: 640 mkg of betamethasone of Dipropionas (that is equivalent to 500 mkg of betamethasone), 20 mg of salicylic acid.

Excipients: dinatrium эдетат, a gipromelloza, sodium hydroxide, isopropanol, the water purified.

Pharmacological properties:

Pharmacodynamics. The combined drug which effect is caused by the components which are its part.

Betamethasone Dipropionas - the synthetic fluorinated GKS - has antiinflammatory, antipruritic and vasoconstrictive effect.

Salicylic acid at topical administration possesses keratolytic, and also bacteriostatic and some fungicidal action.

Indications to use:

— psoriasis of a pilar part of the head or other localization;

— seborrhea of a pilar part of the head;

— other dermatosis which is giving in to therapy of GKS.

Route of administration and doses:

Outwardly. To put with a thin layer of 2 times/days - in the morning and for the night, completely covering affected areas of skin. At some patients of the supporting effect it is possible to reach less frequent applications.

Duration of a course of treatment is defined by its efficiency, and also portability the patient, existence and expressiveness of side effects.

Features of use:

Use at pregnancy and feeding by a breast. Safety of use of local GKS for pregnant women is not established.

As so far it is not found out whether local GKS get into mother's milk, it is necessary to resolve an issue of the termination of breastfeeding or use of drug.

Use at abnormal liver functions.

With care: liver failure.

Use for children. Children are more subject to risk of oppression of function гипоталамо - pituitary and adrenal system owing to use of local GKS, than adults, because of a bigger ratio of body surface area at them both weight and, respectively, the increased drug absorption.

Special instructions. If against the background of Diprosalik Losyon's use the irritation of skin or hypersensitivity to drug appeared, treatment should be stopped. In case of accession of an infection it is necessary to appoint the corresponding therapy.

System absorption of GKS and salicylic acid at their topical administration by that will be higher, than the big body surface is exposed to treatment. It is necessary to take the appropriate measures of precaution if long use of drug, especially at children is supposed.

Putting salicylic acid on an open wound or the injured skin is not allowed.

At Diprosalik Losyon's use it is impossible to use the closing bandages.

At emergence of dryness or irritation of skin, treatment by drug should be stopped.

At prolonged treatment by drug its cancellation is recommended to be carried out gradually.

Diprosalik Losyon is not intended for use in ophthalmology. It is necessary to avoid hit in eyes and on mucous membranes.

Prolonged use on face skin is not recommended. It is necessary to avoid use in anogenitalny area.

Use in pediatrics. Children are more subject to risk of oppression of function гипоталамо - pituitary and adrenal system owing to use of local GKS, than adults, because of a bigger ratio of body surface area at them both weight and, respectively, the increased drug absorption.

Function suppression гипоталамо - pituitary and adrenal system at children is defined by the low level of cortisol in plasma and lack of the response to stimulation of adrenocorticotropic hormone. Increase in intracranial pressure is shown by protrusion of a fontanel, headaches, a bilateral papilledema.

Side effects:

Burning, itch, irritation of skin, xeroderma, folliculitis, hypertrichosis, acne rash, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of skin, consecutive infection, atrophy of skin, striya, heat rash, pain, skin cracks, dermatitis, purpura, teleangiectasias, local hirsutism.

At topical administration of GKS during the long period and/or in the raised doses, especially at children, the side effects characteristic of system GKS can develop (including function suppression гипоталамо - pituitary and adrenal system, development of a syndrome of Cushing, a growth inhibition, an insufficient gain of body weight and increase in intracranial pressure).

Drugs of salicylic acid can cause dermatitis.

Contraindications:

— hypersensitivity to any of drug components;

— children's age up to 2 years;

— pregnancy;

— lactation period;

— pink eels;

— perioral dermatitis;

— bacterial, viral or fungal infection of skin (pyoderma, syphilis, tuberculosis cutis, Negres of simplex, chicken pox, Herpes zoster, actinomycosis, zymonematosis, sporotrichosis);

— trophic ulcers against the background of chronic venous insufficiency;

— skin tumors (carcinoma cutaneum, nevus, atheroma, epithelioma, melanoma, hemangioma, xanthoma, sarcoma);

— postvaccinal skin reactions;

With care: children's age up to 12 years; liver failure; long therapy.

Overdose:

Symptoms: long use of GKS for topical administration in the raised doses can cause the suppression of gipofizo-adrenal system leading to secondary insufficiency of function of adrenal glands and the phenomena of a hypercorticoidism including Cushing's syndrome.

Long use of drugs of salicylic acid for topical administration in the raised doses can cause symptoms of poisoning with salicylates (early symptoms - nausea and vomiting).

Treatment: symptomatic.

At overdose of GKS - if necessary - correction of an electrolytic imbalance. At poisoning with salicylic acid it is necessary to take measures for bystry removal of salicylic acid from an organism, for example, sodium bicarbonate intake - for alkalization of urine and forcing of a diuresis.

Storage conditions:

To store in the place, unavailable to children, at a temperature from 2 to 25 °C. A period of validity - 2 years. Not to use drug after a period of validity.

Issue conditions:

According to the recipe

Packaging:

30 ml - a bottle dropper plastic (1) - packs cardboard.