Milistan sine

General characteristics. Structure:

Active ingredients: 500 mg of paracetamol, 10 mg of a tsetirizin of a hydrochloride.

Excipients: cellulose microcrystallic, starch, gelatin, methylparaben, propylparaben, the purified water, magnesium stearate, the purified talc, silicon dioxide colloid, sodium lauryl sulfate, sodium krakhmalglikolit, a gidroksipropilmetiltsellyuloza, ethyl cellulose, titanium dioxide, propylene glycol.

Pharmacological properties:

Pharmacodynamics. Paracetamol has analgetic, febrifugal and weak antiinflammatory action. The action mechanism connected with inhibition of synthesis of prostaglandins and it is preferential influence on the center of thermal control in a hypothalamus.

Tsetirizina a hydrochloride - the selection antagonist of peripheral H1 - histamine receptors, Hydroxyzinum metabolite. Antiallergic action thanks to inhibition of a late phase of migration of cells which participate in inflammatory reaction possesses (preferential eosinophils); also reduces an expression of molecules of adhesion, such as ICAM-1 and VCAM-1 which are markers allergic an inflammation. Suppresses action of other mediators and inductors of secretion of a histamine, such as PAF (тромбоцитоактивируюй a factor) and substance P.

Pharmacokinetics. Absorption. After internal use drug quickly and almost is completely soaked up from a digestive tract. Administration of drug along with food does not influence volume absorption, but slightly reduces its speed.

Distribution. Drug is well distributed in fabrics (except for fatty tissue) and cerebrospinal fluid. Linkng of paracetamol with proteins of a blood plasma makes about 10% and slightly increases at overdose. Tsetirizin is also capable to contact proteins of a blood plasma. Distribution volume low (l/kg Vd 0, 5).

Metabolism. Paracetamol is metabolized preferential in a liver by conjugation with a glucuronide, sulfate and oxidation with participation of the mixed oxidases of a liver and P450 cytochrome. Tsetirizin in a liver is practically not metabolized.

Removal. The elimination half-life of paracetamol makes 1-3 hour. At patients with cirrhosis the elimination half-life lasts. The renal clearance of paracetamol makes 5%. It is removed with urine, generally in the form of glyukuronidny and sulphatic conjugates. Less than 5% are removed in the form of not changed paracetamol. After single internal use of a tsetirizin of a hydrochloride the elimination half-life makes approximately the 10th hour. Active ingredients of drug get through a placenta and are removed with breast milk.

Indications to use:

Acute and chronic inflammation of adnexal nasal cavities (sinusitis, antritis, frontal sinusitis); acute rhinitis of a virus or bacterial origin; allergic rhinitis; pain of weak and moderate intensity, including headache, migraine, dentagra, neuralgia, mialgiya, альгодисменорея; pain at injuries, burns; a diarrhea at infectious and inflammatory diseases; allergic rhinitis, allergic conjunctivitis, a dermatosis which are connected with an itch, a small tortoiseshell (including a chronic idiopathic small tortoiseshell).

Route of administration and doses:

The dose is established individually. At treatment of adults and children 12 years are more senior apply 1 kapleta 2 times for days with an interval not less 4th hour. The maximum duration of treatment – 5 - 7 days.

The patient with moderately expressed or severe form of a renal failure appoint a half of the recommended dose.

Dose adjustment is not necessary for patients of advanced age with normal function of kidneys.

Features of use:

Pregnancy and lactation. Use of Milistan to the Sine during pregnancy perhaps only when the predicted advantage for mother exceeds potential risk for a fruit. It is desirable to abstain from use of drug during feeding by a breast, or it is necessary to resolve an issue about suspension feeding by a breast.

At treatment of patients with a high-quality hyperbilirubinemia, and also patients of advanced age it is necessary to use drug under the supervision of the doctor. At prolonged use of drug control of peripheral blood and a functional condition of a liver is necessary (1 time for 10 days).

Influence on ability to manage motor transport and mechanisms. Objective methods of studying of ability to manage potentially unsafe types of activity definitely did not reveal any undesirable phenomena at use of drug in the recommended doses.

During use of drug it is impossible to take alcohol!

Side effects:

From a digestive tract and a liver: dryness in a mouth, in isolated cases – dyspepsia; at prolonged use in high doses – a hepatotoxic action.

From the central nervous system: not sharply expressed and quickly passing drowsiness, a headache, fatigue are possible; in certain cases – excitement.

From system of a hemopoiesis: seldom - thrombocytopenia, a leukopenia, a pancytopenia, a neutropenia, an agranulocytosis.

Allergic reactions: very seldom – a Quincke's disease; enanthesis, itch, urticaria.

Interaction with other medicines:

At simultaneous use with barbiturates, anticonvulsants, rifampicin, and also at alcohol intake the risk of a hepatotoxic action considerably increases.

At combined use of Milistan to the Sine with Metoclopramidum increase in absorption of paracetamol is possible.

At simultaneous use of Milistan to the Sine and derivatives of coumarin development of an insignificant prothrombinopenia is possible.

Caffeine can exponentiate the anesthetizing effect of paracetamol.

Contraindications:

Hypersensitivity to drug components, an alcoholism, the expressed abnormal liver functions and/or kidneys, children's age up to 12 years, pregnancy, the feeding period a breast.

Overdose:

The sleep disorder, itch, enanthesis, disturbance urination, fatigue, a tremor, tachycardia are possible.

Treatment: carry out symptomatic therapy. The hemodialysis is inefficient.

Storage conditions:

To store at the room temperature, in protected from light and the place, unavailable to children. Period of storage 3 years.

Issue conditions:

Without recipe

Packaging:

On 10 kaplt in blister strip packagings, on the 2nd blister strip packagings in a cardboard pack together with the application instruction.