To Koldakt Fl plus suspension

General characteristics. Structure:

Active agents: Phenylephrinum a hydrochloride - 5 mg; chlorphenaminum (chlorpheniramine) a maleate - 2 mg; paracetamol - 125 mg

Pharmacological properties:

The combined drug which effect is caused by the components which are its part. Renders febrifugal, alpha адреностимулирующее, vasopressor and antihistaminic action, eliminates cold symptoms.
 
Paracetamol blocks TsOG preferential in TsNS, influencing the centers of pain and thermal control that explains almost total absence of antiinflammatory effect. Lack of influence of paracetamol on synthesis of prostaglandins in peripheral fabrics causes absence at it negative influence on a water salt metabolism (Na delay + and waters) and a mucous membrane of a GIT.
 
Phenylephrinum - alpha адреномиметик, narrows vessels, eliminates puffiness and a hyperemia of a mucous membrane of a nasal cavity, a nasopharynx and adnexal bosoms of a nose; reduces exudative manifestations.

Chlorphenaminum - H1 blocker - histamine receptors, suppresses symptoms of allergic rhinitis: sneezing, rhinorrhea, itch of eyes, nose, throat.

The beginning of action - 20-30 min., duration - 4-4.5 h.

Indications to use:

— a feverish syndrome at catarrhal and infectious diseases;
— sinusitis;
— rhinorrhea (acute rhinitis, allergic rhinitis).

Route of administration and doses:

Inside. The adult - on 2 tablets with an interval of 4 h. The maximum daily dose - the 12th tablets
 
To children 6 years - 1 tablets with an interval of 4 h are more senior; the maximum daily dose - the 5th tablets within no more than 7 days.

Features of use:

At the hyperthermia proceeding more than 3 days and a pain syndrome more than 5 days, consultation of the doctor is required.
 
The risk of development of injuries of a liver increases at patients with an alcoholic hepatosis.
 
Distorts indicators of laboratory researches at quantitative definition of glucose and uric acid in plasma.
 
In case of prolonged treatment carry out control of indicators of peripheral blood and a functional condition of a liver.
 
During treatment it is necessary to abstain from the ethanol use (possibly development of a hepatotoxic action), driving of motor transport and occupations other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.

Side effects:

Allergic reactions (skin rash, itch, small tortoiseshell, Quincke's disease), nausea, epigastric pain; anemia, thrombocytopenia, agranulocytosis. Hyperexcitability, dizziness, increase in the ABP, backfilling disturbance. A mydriasis, accommodation paresis, increase in intraocular pressure, dryness in a mouth; ischuria.
 
At prolonged use in high doses - a hepatotoxic action, hemolitic anemia, aplastic anemia, a methemoglobinemia, a pancytopenia; nephrotoxicity (renal colic, glucosuria, intersticial nephrite, papillary necrosis).

Interaction with other medicines:

Strengthens effects of MAO inhibitors, sedatives, ethanol. Ethanol strengthens sedative effect of antihistaminic medicines.

Antidepressants, fenotiazinovy derivative, protivoparkinsonichesky and antipsychotic medicines increase risk of development of an ischuria, dryness in a mouth, locks.

At a concomitant use of GKS increase risk of development of glaucoma.

Paracetamol reduces efficiency of uricosuric medicines.

Chlorphenaminum along with MAO inhibitors, furasolidone can lead to hypertensive crisis, excitement, a hyper pyrexia.

Tricyclic antidepressants strengthen adrenomimetichesky action of Phenylephrinum, co-administration of a halothane increases risk of development of ventricular arrhythmia.

Reduces hypotensive action of a guanetidin who in turn increases alpha адреностимулирующую activity of Phenylephrinum.

Contraindications:

— hypersensitivity;
— pregnancy;
— lactation period;
— children's age (up to 6 years).
 
With care: deficit glyukozo-6-fosfatdegidrogenazy; blood diseases, liver and/or renal failure, closed-angle glaucoma, prostate hyperplasia; inborn hyperbilirubinemias (Gilbert's syndromes, Cudgel Johnson and Rotor), arterial hypertension, thyrotoxicosis, diabetes mellitus, bronchial asthma, HOBL (emphysema of lungs, chronic bronchitis).

Use at pregnancy and feeding by a breast. It is contraindicated at pregnancy, in the period of a lactation.

Use at abnormal liver functions. With ostorozhnostyyu:pechenochny insufficiency.

Use at renal failures. With care: renal failure.

Use for children. It is contraindicated at children's age up to 6 years.

Overdose:

Symptoms (are caused by paracetamol, over 10-15 g are shown after reception): pallor of integuments, loss of appetite, nausea, vomiting; гепатонекроз; increase in activity of "hepatic" transaminases, increase in a prothrombin time.
 
Treatment: a gastric lavage in the first 6 h, introduction of donators of SH-group and predecessors of synthesis of glutathione - methionine in 8-9 h after overdose and N-Acetylcysteinum in 12 h.

Issue conditions:

Without recipe

Packaging:

60 ml - bottles of dark glass (1) complete with a dosing spoon - packs cardboard.