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Inosine

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Producer: JSC Binnofarm Russia

Code of automatic telephone exchange: C01EB

Release form: Firm dosage forms. Tablets.

Indications to use: Coronary heart disease. Myocardial dystrophy. Acute myocardial infarction. Arrhythmia. Hepatitis. Cirrhosis. Fatty degeneration of a liver. Acute myocardial infarction. Liver dystrophy.


General characteristics. Structure:

Active ingredient: 200 mg of inosine (inosine) in 1 tablet.

Excipients: potato starch, refined sugar (sucrose), povidone (polyvinylpirrolidone low-molecular medical or пласдон), stearic acid, magnesium stearate.

Structure film obolochki:gidroksipropiltsellyuloza (hypro rod), titanium dioxide, talc, polyethyleneglycol (macrogoal 4000), tropeolin O (dye tropeolin O).




Pharmacological properties:

Pharmacodynamics. Metabolic means, predecessor of adenosinetriphosphate; has anti-hypoxemic, metabolic and antiarrhytmic effect. Increases power balance of a myocardium, improves coronary circulation, prevents effects of intraoperative ischemia of kidneys. Is directly involved in exchange of glucose and promotes activation of exchange in the conditions of a hypoxia and in the absence of adenosinetriphosphate. Activates metabolism of pyruvic acid for ensuring normal process of tissue respiration, and also promotes activation of a xanthinedehydrogenase.

Stimulates synthesis of nucleotides, increases activity of some enzymes of a tricarbonic acid cycle. Getting into cells, raises energy level, has positive effect on processes of exchange in a myocardium - increases force of reductions of heart and promotes fuller relaxation of a myocardium in a diastole therefore the stroke output increases. Reduces aggregation of thrombocytes, activates an angenesis (especially a myocardium and a mucous membrane of digestive tract).

Pharmacokinetics. It is well absorbed in digestive tract. It is metabolized in a liver with formation of glucuronic acid and the subsequent its oxidation. In insignificant quantity it is removed with urine.


Indications to use:

Appoint the adult in complex therapy of coronary heart disease, a myocardial dystrophy, after a myocardial infarction, the disturbances of a heart rhythm caused by use of cardiac glycosides.

Appoint at hepatitises, cirrhosis, fatty dystrophy of the liver caused by alcohol or medicines and urokoproporfiriya.


Route of administration and doses:

Appoint inside to food. The daily dose at intake makes 0,6-2,4 g. In the first days of treatment the daily dose is equal to 0,6-0,8 g (on 200 mg 3-4 times a day).

In case of good tolerance the dose is raised (for 2-3 day) to 1,2 g (400 mg 3 times a day), if necessary – to 2,4 g a day. Course duration – from 4 weeks to 1,5-3 months.

At an urokoproporfiriya the daily dose makes 0,8 g (on 200 mg 4 times a day). Drug is accepted daily within 1-3 months.



Side effects:

Allergic reactions in the form of a small tortoiseshell, a skin itch, a dermahemia are possible (drug withdrawal is required). Seldom at treatment by drug concentration of uric acid in blood and an exacerbation of gout (increases at prolonged use).



Contraindications:

Hypersensitivity to drug, gout, a hyperuricemia.

With care: renal failure.



Storage conditions:

To store in the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children. A period of validity - 3 years. Not to use after the expiry date specified on packaging.


Issue conditions:

According to the recipe


Packaging:

Tablets, film coated 200 mg. On 10 tablets in a blister strip packaging from a film of polyvinyl chloride and aluminum foil. On 2, 3 or 5 blister strip packagings together with the application instruction place in a pack from a cardboard.



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