To Neofl 750

General characteristics. Structure:

Active agents: paracetamol of 750 mg; Phenylephrinum hydrochloride of 10 mg; ascorbic acid of 70 mg.

Pharmacological properties:

The combined drug which effect is caused by the components which are its part.
Has febrifugal, analgeziruyushchy, vasoconstrictive effect, eliminates cold symptoms. Narrows nose vessels, eliminates hypostasis of a mucous membrane of a nasal cavity and a nasopharynx, fills shortage of vitamin C at catarrhal diseases.

Indications to use:

Symptomatic treatment of the catarrhal diseases and flu which are followed by fervescence, a headache, a fever, a nose congestion, pharyngalgias and nasal bosoms.

Route of administration and doses:

Inside at the first symptoms of flu or catarrhal disease: the adult - on 1 pack ice. each 4-6 h, but no more 4th pack ice. during 24 h; to children 12 years - on 1 pack ice are more senior. each 6 h, but no more 3rd pack ice. during 24 h.
Course of treatment - no more than 5 days.
Contents of packaging are dissolved in 250 ml of hot water, to stir before dissolution; if necessary add sugar or cold water.

Features of use:

At preservation of symptoms of a disease more than 5 days consultation of the doctor is required.
Distorts results of the laboratory tests estimating concentration of glucose and uric acid in plasma.
It is not necessary to use at the same time other medicines containing paracetamol, and also other non-narcotic analgesics, NPVS (metamizol, acetylsalicylic acid, an ibuprofen, etc.), barbiturates, antiepileptic medicines, rifampicin, chloramphenicol.

Side effects:

Paracetamol: allergic reactions (skin rash, a small tortoiseshell, a Quincke's disease), it is rare - thrombocytopenia, a leukopenia, an agranulocytosis; at prolonged use - gepato-and nephrotoxic action.
Phenylephrinum: nausea, headache, increase in the ABP, heartbeat.

Interaction with other medicines:

Stimulators of a microsomal oxidation in a liver (Phenytoinum, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase products of hydroxylated active metabolites of paracetamol that causes a possibility of development of heavy intoxications at small overdoses.
Paracetamol strengthens effects of MAO inhibitors, sedative medicines, ethanol.
The antidepressants, protivoparkinsonichesky, antipsychotic medicines derivative of a fenotiazin - risk of an ischuria, dryness in a mouth, a lock.
GKS - risk of development of glaucoma.
Phenylephrinum reduces hypotensive effect of a guanetidin.
Guanetidin strengthens alpha адреностимулирующий effect, and tricyclic antidepressants - sympathomimetic effects of Phenylephrinum.

Contraindications:

— hypersensitivity;
— the expressed renal/liver failure;
— hyperthyroidism;
— diseases of cardiovascular system (the expressed aortal stenosis, an acute myocardial infarction, a tachyarrhythmia);
— arterial hypertension;
— prostate hyperplasia;
— closed-angle glaucoma;
— a concomitant use of tricyclic antidepressants, beta adrenoblockers, MAO ingibtor (including within 14 days after their cancellation), other paratsetamolsoderzhashchy medicines;
— a diabetes mellitus and inherited disorders of absorption of glucose (for the dosage forms containing sugar);
— children's age (up to 12 years).

With care: high-quality hyperbilirubinemias, deficit glyukozo-6-fosfatdegidrogenazy, pregnancy, lactation period.

Use at pregnancy and feeding by a breast
With care: pregnancy, lactation period.

Use at abnormal liver functions
Contraindication — the expressed liver failure.

Use at renal failures
Contraindication — the expressed renal failure.

Use for children
Contraindication — children's age (up to 12 years).

Overdose:

The symptoms (caused by paracetamol): pallor of integuments, anorexia, nausea, vomiting, increase in activity of hepatic transaminases, increase in a prothrombin time, гепатонекроз.

Treatment: gastric lavage, absorbent carbon, symptomatic therapy. A specific antidote - Acetylcysteinum.

Storage conditions:

In the dry place, at a temperature not above 25 °C.

Issue conditions:

Without recipe

Packaging:

Powder for пригот. solution for intake of 750 mg +10 mg +70 mg / 5.