Vero-loperamid

General characteristics. Structure:

Tablets of color, white or white with a yellowish shade, ploskotsilindrichesky form.

Pharmacological properties:

Pharmacodynamics. Loperamide, contacting opioid receptors of an intestinal wall (modulation sincaline - and adrenergic neurons through guaninnukleotida), reduces a tone and motility of smooth muscles of intestines (at the expense of inhibition of release of acetylcholine and Pg). Slows down a peristaltics and increases time of passing of intestinal contents. Raises a tone of a proctal sphincter, promotes deduction of fecal masses and an urezheniye of desires to defecation.
Action comes quickly and continues 4–6 h.

Pharmacokinetics. Absorption — 40%. Tcmax (the maximum concentration in a blood plasma) is 2,5 h. Communication with proteins of plasma — 97%. Does not get through a blood-brain barrier (GEB).
It is almost completely metabolized by a liver by conjugation. T1/2 (elimination half-life) — 9–14 h. It is removed preferential with bile and kidneys (in the form of the conjugated metabolites).

Indications to use:

Symptomatic treatment of acute and chronic diarrhea of various genesis (allergic, emotional, medicinal, beam; at change of a diet and qualitative structure of food, at disturbance of metabolism and absorption; as supportive application at diarrhea of infectious genesis).
Regulation of a chair at patients from ileostomy.

Route of administration and doses:

Inside. The adult at acute and chronic diarrhea appoint 2 tablets (4 mg) in an initial dose; then — on 1 tablet (2 mg) after each act of defecation (in case of a liquid chair); the maximum daily dose — 8 tablets (16 mg).

At acute diarrhea to children 5 years are more senior appoint in an initial dose 2 mg, then on 2 mg after each act of defecation; the maximum daily dose — 3 tablets (6 mg).

At normalization of a chair or in the absence of a chair more than 12 hours treatment by Loperamide should be stopped.

Features of use:

In the absence of effect after two days of treatment it is necessary to specify the diagnosis and to exclude infectious genesis of diarrhea. If at treatment locks or abdominal distention develop, loperamide should be cancelled. At patients with an abnormal liver function careful control of signs of toxic defeat of TsNS is necessary. During treatment of diarrhea it is necessary to make up for loss of liquid and electrolytes. During treatment it is necessary to abstain from occupations potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.

Side effects:

Gastralgia, dryness in a mouth, allergic reactions (skin rash), drowsiness, dizziness, intestinal colic, nausea, vomiting, locks. Extremely seldom — intestinal impassability.

Contraindications:

Hypersensitivity to drug, a divertuculosis, intestinal impassability, ulcer colitis in an aggravation stage, diarrhea against the background of an acute pseudomembranous coloenteritis, in the form of monotherapy — dysentery and other infections of digestive tract; pregnancy (the I trimester), the lactation period, children's age (up to 5 years).

With care: apply loperamide at a liver failure.

Overdose:

Symptoms: oppression of the central nervous system (CNS) (stupor, lacks of coordination of movements, drowsiness, miosis, muscular hypertension, respiratory depression), intestinal impassability.

Treatment: antidote Naloxonum; considering that duration of effect of loperamide is more, than at Naloxonum, perhaps repeated introduction of the last. Symptomatic treatment: absorbent carbon, gastric lavage, artificial ventilation of the lungs (AVL). Medical observation, at least, within 48 hours is necessary.

Storage conditions:

In dry protected from light, the place, unavailable to children, at a temperature not above 25 °C.
Period of validity 3 years. Not to use drug expired.

Issue conditions:

Without recipe

Packaging:

Tablets on 2 mg. On 10 tablets in a blister strip packaging. On 10 or 20 tablets in bank of light-protective glass. Each can or 1, 2 blister strip packagings together with the application instruction are placed in a pack from a cardboard.