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medicalmeds.eu Medicines Antidiarrheal means. Loperamide

Loperamide

Препарат Лоперамид. ЗАО "ФП "ОБОЛЕНСКОЕ" Россия


Producer: CJSC FP OBOLENSKOYE Russia

Code of automatic telephone exchange: A07DA03

Release form: Firm dosage forms. Capsules.

Indications to use: Ileostoma. Diarrhea. Diarrhea of travelers. Nervous diarrhea. Viral diarrhea.


General characteristics. Structure:

Active ingredient: 2 mg of loperamide of a hydrochloride in 1 capsule.

Excipients: starch corn, cellulose microcrystallic, magnesium stearate.

Gelatinous solid capsules (titanium dioxide, ferrous oxide black, yellow quinolinic, patent blue, diamond black, yellow sunset, gelatin).




Pharmacological properties:

Pharmacodynamics. Reduces a tone and motility of smooth muscles of intestines, slows down an intestines contents passage, reduces release of liquid and electrolytes with excrements. Raises a tone of a proctal sphincter. Action comes quickly and 4-6 hours proceed.

Pharmacokinetics. Absorption – 40%. Communication with proteins of plasma – 97%. An elimination half-life – 9-14 h. Does not get through a blood-brain barrier. It is almost completely metabolized in a liver by conjugation. It is removed preferential with bile and kidneys.


Indications to use:

Symptomatic treatment of acute and chronic diarrhea of various genesis (allergic, emotional, medicinal, beam; at change of a diet and qualitative structure of food, at disturbance of metabolism and absorption; as supportive application at diarrhea of infectious genesis).

Regulation of a chair at patients from ileostomy.


Route of administration and doses:

Inside. Adult at acute and chronic diarrhea originally appoint 2 capsules (4 mg), then on 1 capsule (2 mg) after each act of defecation in case of a liquid chair. The maximum daily dose – 8 capsules (16 mg).

To children 6 years are more senior appoint on 1 capsule (2 mg) after each act of defecation in case of a liquid chair. The maximum daily dose – 3 capsules (6 mg).

After normalization of a chair or in the absence of a chair more than 12 hours treatment by Loperamide should be stopped.


Features of use:

In the absence of effect after 2 days of use of Loperamide it is necessary to specify the diagnosis and to exclude infectious genesis of diarrhea.


Side effects:

Headache; a gastralgia, dryness in a mouth, allergic reactions (skin rash), drowsiness or sleeplessness, dizziness, intestinal colic, nausea, vomiting, a lock. Extremely seldom – intestinal impassability.



Contraindications:

Hypersensitivity to drug, a divertuculosis, intestinal impassability, ulcer colitis in an aggravation stage, diarrhea against the background of an acute pseudomembranous coloenteritis, in the form of monotherapy - dysentery and other infections of digestive tract; pregnancy (the I trimester), the lactation period, loperamide in capsules are not appointed to children up to 6 years.

With care – a liver failure.


Overdose:

Symptoms: oppression of the central nervous system (stupor, lack of coordination, drowsiness, miosis, muscular hypertension, respiratory depression), intestinal impassability.

Treatment: an antidote – Naloxonum; considering that duration of effect of loperamide is more, than at Naloxonum, perhaps repeated introduction of the last. Symptomatic treatment: absorbent carbon, gastric lavage, artificial ventilation of the lungs.

Medical observation, at least, within 48 hours is necessary.


Storage conditions:

In the dry, protected from light place, at a temperature not over 25 ºС. To store in the place, unavailable to children. A period of validity - 3 years. Not to apply after the expiry date specified on packaging.


Issue conditions:

Without recipe


Packaging:

Capsules of 2 mg. On 10 or 20 capsules in a blister strip packaging from a film of the polyvinyl chloride and printing aluminum foil varnished. On 1, 2 or 3 blister strip packagings together with the application instruction place in a pack from a cardboard.



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