Ascorbic acid with glucose

General characteristics. Structure:

Active ingredients: 200 mg of ascorbic acid, 1754 mg of glucose.

Excipients: potato starch, talc, calcium stearate.

The combined drug containing ascorbic acid (vitamin C).

Pharmacological properties:

Pharmacodynamics. Ascorbic acid participates in oxidation-reduction processes, takes part in formation of an active form of folic acid, protects hemoglobin and oxyhemoglobin, iron of tsitokhrom P450. Ascorbic acid plays an important role in biosynthesis of collagen, serotonin, hormones of adrenal glands, a kannitina, promotes release of iron from the connected state with transferrin and to its absorption from intestines.

Vitamin C is extracellular and intracellular antioxidant, actively connects free radicals. Antioxidant effect of ascorbic acid amplifies at combined use of tocopherol and Retinolum. Vitamin C promotes increase in body resistance to an adverse effect of the environment, improves overall health, increases efficiency of action of various therapeutic actions, has radio tire-tread properties, reduces hemorrhagic manifestations of a radial illness and stimulates a krovoobrazovaniye. Glucose - substance which influences exchange processes takes part in carbohydrate and energy balance, is an energy source in an organism.

Pharmacokinetics. Ascorbic acid is soaked up throughout digestive tract, is preferential in a small intestine: in 30-60 min. A vitamin C elimination half-life - 4 - 7 hours after its reception. Surplus is removed with urine in the form of acid ascorbic and its metabolites: treonovy, xylonic, lyxonic and oxalic acids. With increase in a dose up to 200 mg and more absorbability of ascorbic acid decreases. Absorption can be also broken at intestinal diskineziya, enterita and an akhiliya.

Indications to use:

Prevention and treatment hypo - and vitamin C avitaminosis. Satisfaction of the increased need of an organism for vitamin C in a growth period, pregnancies and lactations, at intense exercise and intellectual stresses, overfatigue, stressful states, during recovery after infectious diseases; at different intoxications, hemorrhagic diathesis, at vyalozazhivayushchy and contaminated wounds of soft tissues, fractures of bones.

Route of administration and doses:

Inside after food, previously to chew. For the purpose of prevention: the adult on 1/2 - 1 tablet (100-200 mg) a day, to children since 14 years on 1/2 tablets (100 mg) a day. In the medical purposes: the adult on 1,5 - 2,5 tablets (300-500 mg) a day which divide into 3-5 receptions, to children from 14 years on 1-1,5 tablets (200-300 mg) a day which divide into 2-3 receptions.

At intense exercise and intellectual stresses, overfatigue, stressful states, during recovery after infectious diseases, intoxication and poisoning, hemorrhagic diathesis - on 1,5 - 5 tablets (300-1000 mg) a day, at vyalozazhivayushchy wounds of soft tissues, fractures of bones - on 5 tablets (1000 mg) a day. The course of treatment depends on character and the course of a disease and is defined by the doctor. The maximum daily dose of ascorbic acid for adults - 1000 mg.

With care appoint at deficit glyukozo-6-fosfatdegidrogenazy, for use in high doses - hemochromatosis, sideroblastny anemia, a thalassemia, a hyperoxaluria, нефроуролитиаз.

Features of use:

Simultaneous use of drug with alkaline drink (mineral waters) reduces vitamin C absorption.

Ascorbic acid can influence results of various laboratory researches, for example, when determining content in blood of glucose, bilirubin, activity of transaminases, lactatedihydrogenases.

Patients with the increased content of iron in an organism should apply ascorbic acid in the minimum doses. Purpose of ascorbic acid to patients with quickly main and intensively metastasizing tumors can aggravate the course of process.

Side effects:

Allergic reactions are possible. At the use in the recommended doses of side reactions it is not observed. At long use in high doses there can be a hyperglycemia, a glucosuria, arterial hypertension, a hyperoxaluria and a nephrocalcinosis (oxalic).

Interaction with other medicines:

Ascorbic acid reduces toxicity of sulfanamide drugs, reduces effect of heparin of indirect anticoagulants, increases penicillin absorption, strengthens effect of side effect of salicylates (risk of emergence of a crystalluria). Use of oral contraceptives reduces vitamin C level in an organism. At simultaneous use of low doses of vitamin C and B1, B2 vitamins and in, mutual strengthening of therapeutic action is defined. Vitamin P (routines) considerably improves digestion of vitamin C. It is necessary to avoid simultaneous use of ascorbic acid with therapeutic doses of B12, PP, B6 vitamins, with an Euphyllinum, iron preparations and copper.

Acetylsalicylic acid, fresh juice and alkaline food reduce absorption and digestion of ascorbic acid. Ascorbic acid slows down removal by kidneys of acids, increases removal of the medicines having alkali reaction (including alkaloids), reduces concentration in blood of oral contraceptives. Increases the general clearance of ethanol which in turn reduces concentration of ascorbic acid in an organism. At simultaneous use reduces chronotropic action of an izoprenalin.

At prolonged use or use in high doses Disulfiramum ethanol can break interaction. In high doses increases removal of a meksiletin kidneys. Barbirutorata and Primidonum increase removal of ascorbic acid with urine.

Reduces therapeutic effect of antipsychotic medicines (neuroleptics) - derivatives of a fenotiazin, a canalicular reabsorption of amphetamine and tricyclic antidepressants.

Contraindications:

Hypersensitivity to drug, children's age up to 14 years. It is not necessary to appoint high doses of drug the patient with the increased coagulability of blood, thrombophlebitises, tendency to fibrinferments. And also at the diabetes mellitus and states which are followed by the increased content of sugar in blood.

Overdose:

The overdose promotes the raised thrombogenesis. Long, uncontrolled use of drug can lead to oppression of the insulyarny device of a pancreas, causes considerable change in a metabolism. It needs to be considered, appointing ascorbic acid a sick diabetes mellitus.

Overdose symptoms: at use more than 1000 mg - a headache, increase in excitability TsNS, sleeplessness, nausea, vomiting, diarrhea, hyperacid gastritis, an ultseration of a mucous membrane of a GIT, oppression of function of the insulyarny device of a pancreas (a hyperglycemia, a glucosuria), a hyperoxaluria, a nephrolithiasis, the povrezhdeniyeglomerulyarny device of kidneys, a moderate pollakiuria (at reception of a dose more than 600 mg/days). Decrease in pronitsayemostikapillyar (deterioration in a trophicity of fabrics, increase in the ABP, hypercoagulation, development of mikroangiopatiya is possible).

Storage conditions:

In the place protected from light and moisture at a temperature not above 25 °C. To store in the place, unavailable to children. Period of validity of 18 months. Not to use after the term specified on packaging.

Issue conditions:

Without recipe

Packaging:

On 15 chewable tablets in paper packaging.