Acetylsalicylic acid of a tablet

General characteristics. Structure:

1 tablet contains acetylsalicylic acid 0,5 g; in planimetric bezjyacheykovy packaging of 10 pieces.

Pharmacological properties:

Pharmacodynamics. Has the antiinflammatory, analgeziruyushchy and febrifugal effect connected with suppression of cyclooxygenase 1 and 2, prostaglandins regulating synthesis. Reduces aggregation, a platelet stickness and a thrombogenesis due to suppression of synthesis of A2 thromboxane in thrombocytes. The anti-aggregation effect remains within 7 days after a single dose (it is more expressed at men, than at women).

Indications to use:

Moderately or poorly expressed pain syndrome at adults of various origin (a headache, a dentagra, a dorsodynia and muscles, a joint pain, pain at periods).
The increased body temperature at catarrhal and other infectious and inflammatory diseases (at adults and children 15 years are more senior).

Route of administration and doses:

At a pain syndrome of weak and average intensity and feverish states the single dose makes 0,5-1 g (1-2 tablets), the maximum single dose - 1 g (2 tablets), the maximum daily dose should not exceed 3 g (6 tablets). Intervals between administrations of drug have to be not less than 4 hours. For reduction of irritant action by digestive tract drug should be accepted after food, washing down with water, milk, alkaline mineral water.
Treatment duration (without consultation with the doctor) should not exceed 5 days at appointment as anesthetic and more than 3 days - as an antipyretic.

Side effects:

From digestive tract: abdominal pains, heartburn, nausea, vomiting, a loss of appetite, diarrhea, explicit (vomiting with blood, a tar-like chair) or the hidden symptoms of gastrointestinal bleeding which can lead to an iron deficiency anemia, erosive cankers (including with perforation) digestive tract, isolated cases – abnormal liver functions (increase in hepatic transaminases), a renal failure.
From the central nervous system: dizziness, a sonitus (usually are overdose signs).
From system of a hemopoiesis: increase in risk of bleeding that is a consequence of influence of acetylsalicylic acid on aggregation of thrombocytes; anemia, leukopenia.
Allergic reactions: skin rash, anaphylactic reactions, bronchospasm, Quincke's edema.
At emergence of similar symptoms it is recommended to stop administration of drug and to see immediately the attending physician.

Contraindications:

- hypersensitivity to acetylsalicylic acid and other NPVP or other components of drug;
- digestive tract erosive cankers (in an aggravation phase);
- hemorrhagic diathesis;
- the combined use of a methotrexate in a dose of 15 mg a week and more;
- asthma caused by reception of salicylates or other NPVP;
- pregnancy (I and III trimester), breastfeeding period.
Drug is not appointed to children up to 15 years with the acute respiratory diseases caused by viral infections because of risk of development of a syndrome to Reja (encephalopathy and acute fatty dystrophy of a liver with acute development of a liver failure).

Overdose:

Overdose of moderate severity: nausea, vomiting, sonitus, hearing disorder, headache, dizziness and confusion of consciousness.
Heavy overdose: fever, a hyperventilation, a ketosis, a respiratory alkalosis, a metabolic acidosis, a coma, cardiogenic shock, respiratory insufficiency, the expressed hypoglycemia.
Treatment: hospitalization, lavage, reception of absorbent carbon, monitoring of acid-base balance, an alkaline diuresis to receive рН urine between 7,5-8 (the forced alkaline diuresis is considered reached if concentration of salicylate in a blood plasma makes more than 500 mg/l (3,6 mmol/l) at adults or children have 300 mg/l (2,2 mmol/l)), a hemodialysis, compensation of loss of liquid, symptomatic therapy.

Storage conditions:

In the dry place, at a temperature from 15 to 25 °C. To store in the place, unavailable to children. Period of validity 4 years. Not to use after the term specified on packaging.

Issue conditions:

Without recipe

Packaging:

Tablets on 500 mg.
On 10 tablets in planimetric strip or bezjyacheykovy packaging.
Planimetric bezjyacheykovy or blister strip packagings place in group packaging with the equal number of application instructions.