Asparkam-L

General characteristics. Structure:

Active ingredient: 11,6 g of potassium of asparaginate, 7,9 g of magnesium of asparaginate.

Vspmogatelny substances: water for an injektsya, sorbite.

Pharmacological properties:

Pharmacodynamics. The source of ions of K+ and Mg2+, regulates metabolic processes, promotes recovery of electrolytic balance, has antiarrhytmic effect. Ions of K+ participate as in carrying out impulses on nerve fibrils, and in synoptic transfer, implementation of muscular contractions, maintenance of normal cordial activity. Disturbance of exchange of K+ leads to change of excitability of nerves and muscles.

Active ionic transport supports a high gradient of K+ through a plasma membrane. In small doses of K+ expands coronary arteries, in big - narrows.

Renders negative hrono-and bathmotropic action, in high doses - negative other and dromotropic, and also moderate diuretic action. Mg2 + is a cofactor of 300 enzymatic reactions. An irreplaceable element in the processes providing receipt and an expenditure of energy. Participates in balance of electrolytes, transport of ions, permeability of membranes, neuromuscular excitability. Enters into structure (pentozofosfatny) DNA, participates in RNA synthesis, the heredity device, cellular growth, in the course of cell fission. Limits and prevents excessive release of a catecholamine at a stress. Promotes penetration of K+ into cells.

Asparaginate promotes penetration of K+ and Mg2 + in intracellular space, stimulates intercellular synthesis of phosphates. Drug promotes elimination of deficit of potassium and magnesium, has antiarrhytmic effect, improves a metabolism in a myocardium, normalizes electrolytic balance.

Pharmacokinetics. Ions by K+ and Mg ++ are quickly and fully distributed on all body tissues.

Potassium concentration in a blood plasma remains raised rather not for long because of bystry receipt it in cells and removal from an organism. The considerable share of ions of Mg ++ in plasma (25-30%) forms complex connections with proteins. Ions by K+ and Mg ++ are excreted preferential with urine, in small amounts - with excrements, then, tears, etc. At a renal failure removal of ions of K+ and Mg ++ can be slowed down.

The L-aspartic acid acting as the acid-forming rest is endogenous connection and therefore has higher speed of redistribution in an organism that can provide higher bioavailability.

Indications to use:

As a part of complex therapy:

- completion of deficit of K+ and Mg2+, including at coronary heart disease (including an acute myocardial infarction), chronic heart failure, arrhythmias (including against the background of digitalis intoxication).

Route of administration and doses:

Medicine is entered intravenously kapelno on 300 - 400 ml of solution by 1-2 times a day with a speed of 20-25 thaws a minute. The dose and duration of administration of medicine is defined individually.

Features of use:

It is necessary to use only transparent solutions in the unimpaired bottles. After opening of a bottle drug needs to be used at once. Intravenous administration should be carried out slowly. If when mixing drug with other injection solutions there are opacification or opalescence, then such mixes should not be entered.

Precautionary measures. With care it is necessary to apply: the expressed baked insufficiency; a metabolic acidosis, risk of developing of hypostases, a chronic renal failure (if carrying out regular control of the content of magnesium in blood is impossible); the urolithic diathesis (connected with disturbance of exchange of calcium, magnesium and ammonium of phosphate).

Influence on ability to management of transport and potentially dangerous mechanisms: drivers of vehicles and people whose profession is connected with the increased concentration of attention are recommended to use drug with care.

Use during pregnancy and a laktatsiiya in the period of a lactation and at pregnancy (especially in the I trimester) drug is used with care.

Side effects:

At administration of medicine are possible:

from bodies of a GIT: nausea, vomiting, an abdominal pain, a lock, an ulceration mucous a stomach and a gut, bleeding from bodies of a GIT, a meteorism, dryness in a mouth; from cardiovascular system: AV blockade, paradoxical reaction (increase in number of extrasystoles), bradycardia, lowering of arterial pressure, phlebitis, vein thrombosis;

allergic reactions: face reddening, skin itch;

from a nervous system: dizziness, fatigue, paresis, диспноэ, coma, lack of reflexes;

at bystry intravenous administration - a hyperpotassemia (nausea, vomiting, diarrhea, paresthesia), a gipermagniyemiya (a dermahemia of the person, thirst, bradycardia, a lowering of arterial pressure, muscular weakness, fatigue, paresis, a coma, an areflexia, respiratory depression, spasms).

Interaction with other medicines:

Drug strengthens negative dromo-and bathmotropic effect of antiarrhytmic drugs. Eliminates the hypopotassemia caused by glucocorticosteroids and diuretics. Beta adrenoblockers, cyclosporine, kaliysberegayushchy diuretics, heparin, APF inhibitors, non-steroidal anti-inflammatory drugs can strengthen risk of development of a hyperpotassemia.

The general anesthetics increase the oppressing action by TsNS; at simultaneous use with atrakuriy, dekametoniy, suktsinilkhloridy and succinylcholine strengthening of neuromuscular blockade is possible.

Pharmaceutical we will combine with solutions of cardiac glycosides (improves their portability).

Contraindications:

Hypersensitivity, acute and chronic renal failure, atrioventricular block, oliguria, anury, cardiogenic shock (ABP less than 90 mm Hg), acute metabolic acidosis, arterial hypotension, myasthenia, disturbance of exchange of amino acids, dehydration, hemolysis, Addison's disease, disturbance of exchange of amino acids, deficit of fruktozo-1,6-diphosphatase, poisoning with methanol, hyperpotassemia, gipermagniyemiya.

Overdose:

Symptoms: a hyperpotassemia (bradycardia, falling of the ABP, a vascular collapse, a diastolic stop of cordial activity, neurotoxic symptoms) and a gipermagniyemiya (nausea, vomiting, a lethargy, weakness of a bladder, deterioration in atrioventricular carrying out and ventrikulyarny spread of activation, at higher concentration of ions of Mg ++ in plasma - falling of the ABP, breath paralysis, "a magnesian anesthesia", at extremely high concentration - a diastolic stop of cordial activity). Precursory clinical signs of a hyperpotassemia are usually shown at concentration of K+ in blood serum more than 6 ¼Ý¬ó/l: T tooth point, disappearance of a tooth of U, decrease in a segment of ST, lengthening of an interval of Q-T, expansion of the QRS complex. Heavier symptoms hyperpotassemiasof - paralysis of muscles and a cardiac standstill develop at concentration of K+ - 9-10 ¼Ý¬ó/l.

Treatment: intravenous administration of solution of Calcii chloridum, symptomatic therapy. In the presence of a renal failure extrarenal removal can be carried out by a hemodialysis or peritoneal dialysis.

Storage conditions:

List B. In the place protected from light at a temperature not above 25 °C. Not to freeze. To store in the place, unavailable to children. Period of validity 2 years.

Issue conditions:

According to the recipe

Packaging:

Solution for infusions in bottles on 400 ml.