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Milagin

Препарат Милагин. СП ООО "Сперко Украина" Украина


Producer: JV LLC Sperko Ukraina Ukraine

Code of automatic telephone exchange: G01AA10

Release form: Firm dosage forms. Suppositories.

Indications to use:


General characteristics. Structure:

International and chemical name: clindamycin; metil-7-hlor-6,7,8-trideoksi-6-[[(2S,4R) - 1-methyl-4-propilpirrolidin-2-silt] - karbonilamino]-1-тио-L-трео-α-D-галактооктопиранозид 2-(dihydrogen phosphate);
main physical and chemical properties: suppositories of white or almost white color of a sigaropodobny form;
Active ingredient: clindamycin of phosphate of 0,1 g in terms of clindamycin; excipients: lipophilic basis.




Pharmacological properties:

Pharmacodynamics. Clindamycin belongs to antibiotics of group of linkozamid. Suppresses synthesis of protein in a microbic cell by binding with 50S in subunits of ribosomes. At topical intravaginalny administration has bactericidal action. Clindamycin is active in relation to many gram-positive and gram-negative anaerobe bacterias, gram-positive aerobes. It is highly active in relation to the microorganisms causing a bacterial vaginosis: Gardnerella vaginalis, Mobiluncus spp., Mycoplasma spp., Ureaplasma spp., Chlamydia trachomatis, Peptostreptococcus spp., Bacteroides spp., Haemophylus spp., Corynebacterium spp.

Pharmacokinetics. Clindamycin phosphate in an organism is quickly hydrolyzed with formation of clindamycin which shows antibacterial activity. At intravaginalny use about 30% of clindamycin get to system blood circulation, but its accumulations at long use it is not revealed, the period of system semi-removal at vaginal use makes 1,5 - 2,6 hours.


Indications to use:

The bacterial vaginosis caused by organisms, sensitive to clindamycin.


Route of administration and doses:

On one suppository intravaginalno 1 time a day for the night for 3 days in a row. Suppositories exempt from planimetric packaging and enter deeply into a vagina in a dorsal decubitus with the bent knees tightened to a breast or in situation "on cards". At an opportunity treatment is recommended to be carried out after the termination of periods.


Features of use:

It is not necessary to apply Milagin in the period of periods. During treatment by Milagin it is necessary to refrain from sexual contacts, use of products and means for intravaginalny introduction (tampons, means of hygiene, condoms, vaginal diaphragms).
Pregnancy and lactation. During use for pregnant women it is always necessary to compare advantage of use of drug for mother and potential risk for a fruit. The existing literary data confirm lack of toxic influence on a fruit at use in ІІ - ІІІ pregnancy trimesters. Due to the lack of adequate clinical tests in the I trimester of pregnancy Milagin it is necessary to appoint only in the presence of absolute indications. If there is a need for Milagin's use in the period of a lactation, then feeding by a breast needs to be stopped as clindamycin gets into breast milk.
Influence on a possibility of driving and mechanisms. Drug does not influence ability to drive the car and mechanisms and does not break coordination of movements. Does not interact with alcohol.


Side effects:

Side effects meet extremely seldom and quickly disappear after drug withdrawal. Burning sensations, an itch, emergence of allocations from a vagina, activation of the vaginal infections caused by microorganisms, insensitive to clindamycin, (trichomoniasis) and also vaginal fungal infections are possible. Very seldom there can be by-effects connected with systemic action of clindamycin: menstrual frustration, a dysuria, an exacerbation of pyelonephritis, pain in a stomach, dispeptic frustration, a headache, generalizirovanny all body pain, fever, allergic reactions. All these phenomena quickly disappear after drug withdrawal. As well as when using other germicides, at emergence of the expressed and long diarrhea it is necessary to consider a possibility of development of pseudomembranous colitis.


Interaction with other medicines:

It is necessary to show care at simultaneous use of clindamycin and means which block neuromuscular conductivity, because of a possibility of strengthening and prolongation of a mioplegiya. At treatment by Milagin it is not necessary to use other vaginal medicines.


Contraindications:

Hypersensitivity to antibacterial drugs of group of linkozamid (clindamycin and lincomycin).


Overdose:

At vaginal use of clindamycin are not described. At accidental administration of drug development of the side effects characteristic of system use of clindamycin is inside possible. Symptomatic treatment. Clindamycin is not emitted from an organism at a hemodialysis.


Storage conditions:

To store at a temperature not above +25 °C. To store in the place, unavailable to children. A period of validity — 2 years. Date of issue and a deadline of the validity are specified on packaging.


Issue conditions:

According to the recipe


Packaging:

On 3 suppositories in a blister strip packaging and in a cardboard pack.



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