Пиколакс (drops)

General characteristics. Structure:

Active ingredient: sodium picosulfate;

1 ml of drug contains sodium of a pikosulfat in terms of 100% substance of 7,5 mg (20 drops);

excipients: sorbite (Е 420), sodium methylparahydroxybenzoate (Е 219),

1 M Acidum hydrochloricum solution to рН from 6,0 to 7,0, water for injections.

Pharmacological properties:

The contact purgative of triarilmetanovy group, is activated in a large intestine under the influence of bacterial sulphatases; substance which is released at the same time stimulates sensitive nerve terminations of a mucous membrane of intestines, increases its motility. Use of drug is not followed by tenesmus and enterospasms.

After intake reaches a large intestine without essential absorption where under the influence of a bacterial flora it is split with formation of an active form (free biphenol). The laxative effect develops in 6-12 hours after reception, expressiveness of laxative effect does not correlate with the level of active biphenol in a blood plasma. At course treatment of Pikolaks stimulates growth and metabolic activity of normal intestinal microflora.

Indications to use:

The locks or cases demanding defecation simplification.

Route of administration and doses:

Drug is dosed by the doser of the producer. To adults and children 10 years of 13-27 drops (5-10 mg) are more senior; to children from 4 to 10 years of 7-13 drops (2,5-5 mg). More young than 4 years dosing of 250 mkg/kg of body weight or 2 drops on 3 kg of body weight of the child is recommended to children. Children can add drug to food. Children have effective a single dose of drug. As necessary the course of treatment at the child can be prolonged, but it is preferable to limit it three days.

Пиколакс it is necessary to accept for the night in order that the chair was the next morning.

At the oncological patients receiving high doses of opioids apply to elimination of locks on doctor's orders.

Features of use:

As well as other purgatives, Pikolaks it is not necessary to accept daily long time. At daily need of reception of purgatives it is necessary to find out the reason of locks. Prolonged use of purgatives can lead to an electrolytic imbalance and a hypopotassemia, and also to become the reason of "accustoming" and locks owing to effect of "ricochet". To use with care to elderly people, at a hypopotassemia, the increased content of magnesium in blood, to patients with the weakened organism.

Пиколакс it is effective in elimination of locks at the oncological patients receiving high doses of opioids. Drug contains sorbite therefore patients with rare hereditary intolerance of fructose are not recommended to accept it.

Use during pregnancy and feeding by a breast

The negative effect of a pikosulfat of sodium on the course of pregnancy and fetation is not revealed, however it is possible to use drug at pregnancy only if the estimated advantage for mother exceeds possible risk for a fruit. Sodium пикосульфат is not emitted with breast milk, but in need of use of drug of Pikolaks in the period of a lactation it is necessary to stop breastfeeding.

Ability to influence speed of response at control of motor transport or work with other mechanisms

In therapeutic doses drug does not influence ability to manage vehicles and to work with other mechanisms.

Children

Children without consultation of the doctor should not apply Pikolaks.

Side effects:

At short-term administration of drug side effects are observed seldom.

At prolonged use of drug in much the raised doses disturbances are possible:

from skin: skin rash, small tortoiseshell, itch;

from water and electrolytic balance: loss of potassium, sodium and other electrolytes, development of dehydration is possible;

from the alimentary system: seldom - the dispeptic phenomena, vomiting, nausea, spasms and an abdominal pain, diarrhea, a meteorism, pain in a stomach and area of an anus, strengthening of motility of intestines which pass at reduction of a dose of drug;

from immune system: allergic reactions, Quincke's disease;

from TsNS: very seldom - a headache, increased fatigue, drowsiness, spasms.

Interaction with other medicines:

The electrolytic imbalance can lead to decrease in tolerance to cardiac glycosides. Diuretics or glucocorticosteroids can increase expressiveness of the hypopotassemia caused by Pikolaks's use in high doses. Simultaneous treatment by antibiotics can reduce laxative effect of drug.

Contraindications:

Intestinal impassability; acute inflammatory diseases of intestines and acute diseases of abdominal organs (including acute appendicitis, nonspecific ulcer colitis, peritonitis); the acute abdominal pain which is followed by nausea and vomiting which can indicate the acute inflammatory diseases stated above; heavy dehydration; hypersensitivity to sodium to a pikosulfat and other components of drug.

Overdose:

Symptoms. High doses of Pikolaks can cause liquid excrements, spasms (gripes) in a stomach and clinically significant disturbances of water and electrolytic balance (a hypopotassemia, loss of other electrolytes and liquid), ischemia of a mucous membrane of a large intestine. The long overdose leads to development of chronic diarrhea and an abdominal pain, hypopotassemia, secondary hyper aldosteronism, damage of kidneys and development of a nephrolithiasis, a metabolic alkalosis, a hypopotassemia and muscular weakness as result of a hypopotassemia is possible.

Treatment. Gastric lavage, reception of enterosorbents (absorbent carbon), symptomatic treatment (carrying out correction of water and electrolytic balance, use of spasmolysants).

Storage conditions:

Period of validity 3 years. After opening of a bottle drug is good 28 days. To store in the place, unavailable to children. To store in the place protected from light at a temperature from 15 °C to 25 °C.

Issue conditions:

Without recipe

Packaging:

On 15 ml or 30 ml in the bottle enclosed in a pack.