Laksigal

General characteristics. Structure:

Active agent of sodium of a pikosulfat monohydrate (in terms of 100% substance) 7,50 mg;
excipients: sorbitol of liquid 70% of uncrystallized 680,0 mg, ethylparahydroxysodium benzoate of 0,66 mg, Acidum hydrochloricum of 35% to required quantity, water to 1 ml.

Description: Transparent colourless or with a weak yellowish-brownish shade liquid.

Pharmacological properties:

Pharmacodynamics. Sodium пикосульфат - a purgative. The lipophilic active metabolite of sodium of a pikosulfat contacts receptors of an intestinal wall, blocks absorption of water and electrolytes and strengthens their secretion in an intestines gleam, the peristaltics as a result amplifies, advance of intestinal contents accelerates. Laxative action comes in 10-12 h after reception.

Pharmacokinetics. Sodium пикосульфат as hydrophilic substance is practically not soaked up through lipophilic membranes of cells of intestines. Therefore after sodium intake пикосульфат rather quickly passes through a stomach and a small bowel in an invariable look. About 70% of the accepted dose come to a large intestine in 3 hours after reception. In a large intestine by hydrolysis of sodium of a pikosulfat under the influence of intestinal microorganisms the lipophilic active metabolite which easily gets through biological membranes of cells is formed, stimulating neuroceptors of a mucous membrane of a large intestine. In 12 hours after administration of drug only 8% of the entered dose remain in a large intestine. Within 72 hours of 21% of an active metabolite it is removed through kidneys and 72% - through intestines.

Indications to use:

The locks of various etiology caused by hypotonia and a sluggish peristaltics of a large intestine.

Route of administration and doses:

Inside, to part in a small amount of water, before going to bed.
Adults and children are more senior than 10 years: till 12-24 drops (5-10 mg).
Children from 4 to 10 years: till 6-12 drops (2,5-5 mg).
Depending on effect the dose in the subsequent receptions is increased or reduced.

Features of use:

It is not recommended to use without control of the doctor more than 10 days. At use of sodium of a pikosulfat in high doses and a long time symptoms of a water and electrolytic imbalance, including a hyponatremia can appear. It is impossible to exclude possibilities of development of spontaneous defecation. If character of a chair at reception of sodium of a pikosulfat does not change a long time, it is necessary to consult at the doctor for clarification of the reason of locks.

Influence on ability to management of transport and work with the equipment
Sodium пикосульфат does not influence ability to control of motor transport and other equipment.

Side effects:

As a rule, at short-term use of sodium пикосульфат has practically no side effects. Side effects develop at long administration of drug.
From the alimentary system: aggravation of locks, megacolon. At increase in a dose - gripes, diarrhea, intestinal spasms.
From a metabolism: disturbance of water and electrolytic balance, dehydration, hyponatremia.
From cardiovascular system: lowering of arterial pressure.
From a nervous system: spasms.

Interaction with other medicines:

Antibiotics of a broad spectrum of activity reduce aperient effect; diuretics and glucocorticoids increase probability of emergence of a water and electrolytic imbalance; increase in sensitivity to cardiac glycosides is possible.

Contraindications:

Hypersensitivity to sodium to a pikosulfat, a triarilmetan, paraben and other components of drug, intestinal impassability, the restrained hernia, appendicitis, peritonitis, acute inflammatory diseases of abdominal organs, including pancreatitis and an acute coloenteritis, gastrointestinal and uterine bleedings, an abdominal pain of not clear genesis, nausea, vomiting of not clear genesis, cystitis, the expressed dehydration, a spastic lock, states after abdominal organs operations, pregnancy the I trimester, the breastfeeding period, children's age is younger than 4 years.

With care: The children's age is more senior than 4 years.

Use at pregnancy and during breastfeeding
In II and III trimesters of pregnancy drug can be accepted only in cases when the potential advantage of therapy for mother considerably exceeds potential risk for a fruit.

Overdose:

Symptoms: see the section "Side effect", and also pristupoobrazny abdominal pains, ischemia of a mucous membrane of a large intestine, a hyper aldosteronism, an urolithiasis, defeat of renal tubules.
Treatment: gastric lavage, correction of disturbances of water and electrolytic balance, antispasmodics.

Storage conditions:

Period of validity 3 years. The opened bottle - 18 months. Not to apply after a period of validity, kazanny on packaging. At a temperature from +15 °C to +25 °C. Not to freeze! To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

Drops for intake of 7,5 mg/ml.
10 ml or 25 ml of drug are placed in the bottle of brown glass supplied with a dropper and a cover with control of the first opening.
1 bottle together with the application instruction is placed in a cardboard pack.