- Symptoms of the Syndrome of Gudpascher
- Reasons of the Syndrome of Gudpascher
- Treatment of the Syndrome of Gudpascher
Symptoms of the Syndrome of Gudpascher:
The beginning acute with high fever, a pneumorrhagia or pulmonary bleeding, an asthma. At auscultation abundance of ringing wet rattles in average and lower parts of lungs, radiological — multiple focal or drain blackouts in both pulmonary fields. The heavy, progressing glomerulonephritis develops almost at the same time, quickly bringing to pochech-> ache insufficiency. Repeated pneumorrhagia and a hamaturia lead, as a rule, to the anemia which is aggravated at a renal failure. At a laboratory research: anemia, a leukocytosis and the raised SOE. A characteristic immunological symptom of a disease are antibodies to basal membranes of a kidney. The forecast is usually adverse — death comes in the next 6 months — 1 year from an onset of the illness at the phenomena of a pulmonary and cardiac or renal failure.
Reasons of the Syndrome of Gudpascher:
The etiology is unknown, however communication with a viral and bacterial infection, overcooling is noted the First description of a disease is made during a flu epidemic in 1919. The autoimmune pathogeny as the circulating and fixed antibodies to bazapny membranes of kidneys which are cross reacting with antigens of basal membranes of lungs are found is discussed.
Treatment of the Syndrome of Gudpascher:
Corticosteroids in high doses (Prednisolonum to 100 mg/days) in combination with cytotoxic drugs (Azathioprinum on 150 — 200 mg/days) on condition of early the begun treatment can slow down progressing of a disease. Successful use of a plasma exchange in combination with immunosuppressive therapy is described.