Producer: CIAO Biofarm Ukraine
Code of automatic telephone exchange: J06BA02
Release form: Liquid dosage forms. Solution for infusions.
General characteristics. Structure:
Active ingredients of-1.25 g Ig G,
auxiliary substances – 0.25 g of glucose, 0.125 g of glycine, 0.225 g of sodium of chloride.
Main properties: drug is the protein fraction allocated from serum or the blood plasma of the donors cleared and concentrated by a fractionation method alcohol, which passed a stage of a virus inactivation solvent-detergentnym by method. Transparent or slightly opalescent colourless or yellowish liquid. In process hraneniyavozmozhno emergence of the insignificant deposit disappearing when stirring. Drug does not contain antibiotics and preservatives, in raw materials there are no antibodies to VICh-1, VICh-2, to гепатитуС, a poverkhnostnomuantigenuvirusa of hepatitis B.
Drug represents immunological the active protein fraction of Ig G allocated from a blood plasma of donors, cleared and concentrated by a fractionation method alcohol at a temperature below 0 of 0C which passed a stage of a virus inactivation solvent-detergentnym by method. Contains 4.5-5.5% of protein, it is deprived of anticomplementary properties as a result of processing by a small amount of pepsin in the subacidic environment with the subsequent removal of enzyme an aluminum hydroxide.
Immunological properties are caused by presence of antibodies against various activators - viruses and bacteria (hepatitis A and B, herpes, chicken pox, flu, measles, parotitis, poliomyelitis, a rubella, whooping cough, staphylococcus, colibacillus, pneumococci and other infections).
High performance of intravenous immunoglobulin is reached bystry 100% by receipt in a blood stream of antibodies.
Drug has also nonspecific activity which is shown in increase in resistance of an organism.
Indications to use:
Drug is used for treatment:
• primary syndrome of deficit of antibodies - agammaglobulinemias or hypogammaglobulinemias (an inborn form, the period of physiological deficit at newborns);
• a secondary syndrome of deficit of antibodies - blood diseases, an iatrogenic immunodeficiency, as a result of immunosuppressive treatment, the acquired immunodeficiency (AIDS), especially at infection of children with a virus of an immunodeficiency;
• heavy bacterial and toxic and viral infections; the surgical complications which are followed by bacteremia that septicopyemic states; when training surgical patients for operation;
• cytopenias of various genesis (an acute and chronic leukosis, aplastic anemia, a state after therapy by cytostatics);
• autoimmune diseases (idiopathic Werlhof's disease, etc.);
• prevention and treatment of infections at premature children with a small weight at the birth (1500). Administration of drug to pregnant women with threat of premature births reduces child mortality and threat of development of an infection.
• patients with a pseudorheumatism, seropositive, I-II degree of activity, I-II radiological stage.
Route of administration and doses:
Веноиммун®применяют only in the conditions of a hospital at observance of all rules of an asepsis.
Before introduction drug is maintained at a temperature (20+2) 0C not less than two hours. Opaque solutions and solutions with a deposit are not subject to use.
For a vzroslykhrazovy dose of drug makes 4-8 ml (0.2-0.4 g) to 1 kg of body weight it is well transferred by patients and does not cause side reactions.
At a gistotsitostatichesky miyelosupressiya for the purpose of prevention of the infectious and general complications - 4 ml (0.2 g) on 1 kg of body weight for 4-5 days.
At a gaptenovy agranulocytosis-8.5 of ml (0.42 g) on 1 kg of body weight within 4 days.
At the gipoimmunoglobulinemiya which is observed at chronic lympho-and myeloproliferative diseases, and also at immune and gaptenovy thrombocytopenia for the purpose of prevention and treatment of the infectious and general complications - 4-8 ml (0.2-0.4 g) on 1 kg of body weight within 4-5 days.
For children the single dose of drug makes 3-4 ml (0.15-0.2 g) on 1 kg of body weight. On separate indicators the single dose can increase to 8 ml (0.4 g) by 1 kg of body weight, but it is no more than 10 ml (0.5 g) on 1 kg of body weight.
At primary and secondary immunodeficience - 4 ml (0.2 g) on 1 kg of body weight disposable or are more with an interval of 3-4 weeks.
At heavy bacterial and viral infections - 4-8 ml (0.2-0.4 g) on 1 kg of body weight. The number of transfusions depends on weight of process.
At cytopenias of various genesis - 4 ml (0.2 g) on 1 kg of body weight daily within 5 days or 20 ml (1 g) on 1 kg of body weight within 2 days.
At autoimmune diseases - 4-8 ml (0.2-0.4 g) on 1 kg of body weight daily within 5 days or 20 ml (1 g) on 1 kg of body weight within 2 days. The course dose should not exceed 2 g on 1 kg of body weight.
Веноиммун® just before introduction to children part sterile 0.9% with chloride sodium solution: 1 volume of drug on 1 volume of solution for cultivation (in the presence of side reactions cultivation 1:4 is possible).
Divorced Venoimmun®vvodyat intravenously, kapelno with a speed of 5-10 thaws a minute. The course of treatment consists of 1-2 or 5 transfusions which carry out daily. According to indications the course of treatment can be repeated in 3-4 weeks.
At a pseudorheumatism, seropositive, the I-II degree of activity, the I-II radiological stage – the medical dose of drug makes 0.2 g on 1 kg of body weight. Веноиммун®непосредственно before introduction part sterile 0.9% with chloride sodium solution from calculation: 1 volume of drug is at 1 volume of solution; administer the drug intravenously with a speed of 10-15 thaws a minute daily.
The course of treatment - 5 droppers within 5 days also makes 50-80 g of drug.
Features of use:
For administration of drug it is necessary to use separate system.
Transfusion therapy of Venoimmunom®mozhet to be carried out in a complex with other medicines.
Reactions to introduction of Venoimmuna®, as a rule, are absent. In rare instances local reactions in the form of a hyperemia and temperature increase to 37.5 ° C within the first days can develop. At certain people with the changed reactivity allergic reactions of various type, and in exclusively exceptional cases – an acute anaphylaxis can develop. In this regard the persons who received drug have to be under medical observation within 30 minutes.
The drug is not administered to the persons having allergic reactions to blood proteins of the person in the anamnesis.
To the persons having allergic diseases or inclined to allergic reactions administration of drug is carried out against the background of antihistamines. At the same time it is recommended to continue reception of antihistamines within eight days after the termination of a course of treatment.
In the period of an aggravation of allergic process administration of drug is carried out behind vital indicators after permission of the allergist.
To the persons having diseases in which genesis leaders are immunopathological mechanisms (collagenoses, immune diseases of blood, nephrite) drug it is appointed after consultation of the corresponding specialist.
Drug is stored in the dry, protected from light place at a temperature from 2 °C to 8 °C. Not to freeze drug! To store in the place, unavailable to children.
Transportation should be carried out at a temperature from 2 °C to 8 °C.
According to the recipe
On 50 ml in bottles No. 1.