Abrol

General characteristics. Structure:

30 mg operating a veshchestvo:ambroksola of a hydrochloride.

Auxiliary veshchestva:tsellyuloza microcrystallic, croscarmellose sodium, silicon dioxide colloid anhydrous, magnesium stearate.

Pharmacological properties:

Ambroxol increases secretion of respiratory tracts, strengthens release of pulmonary surfactant and stimulates tsiliarny activity. It leads to improvement of mucifying and its removal (mukotsiliarny clearance). Activation of secretion of liquid and increase in mukotsiliarny clearance facilitate removal of slime and reduce cough.

Absorption of all peroral forms of Ambroxol bystry and full, with linear dependence in the therapeutic range. The maximum levels in plasma are reached in 0,5 - 3 h. In plasma in the therapeutic range about 90% of drug contacts proteins.

At internal reception distribution of Ambroxol from blood in fabric bystry and sharply expressed, with high concentration of active agent in lungs. Plasma elimination half-life makes 7 - 12 h; cumulation is not revealed. At oral administration of nearly 30% of drug it is excreted with a stake. Ambroxol is metabolized, generally in a liver by conjugation. The general renal excretion makes about 90%.

Indications to use:

Mucolytic therapy at the acute and chronic bronkhopulmonalny diseases connected with disturbance of bronchial secretion and weakening of advance of slime.

Route of administration and doses:

For achievement of successful treatment the following mode of administration of drug Abrol is recommended.
Adults and children are more senior than 12 years: on 1 tablet 3 times a day.
The therapeutic effect can be reached at use of 2 tablets 2 times a day.
Pill should be taken after food and to wash down with water. Treatment duration – from 4 to 14 days, depending on the course of a disease.

Features of use:

Use during pregnancy or feeding by a breast. It is not recommended to use drug during pregnancy, especially in the I trimester.
Ambroxol gets into breast milk therefore during treatment by drug Abrol it is necessary to stop feeding by a breast.

Ability to influence the speed of reactions at control of motor transport or work with other mechanisms. There are no data on a negative impact of drug on the speed of psychomotor reactions.

Children. Ambroxol use aged up to 12 years is not recommended to children in this dosage form.

Side effects:

As a rule, drug Abrol is well transferred by patients. But there can sometimes be side reactions from digestive tract: nausea, vomiting, dyspepsia; allergic reactions in the form of skin rashes are occasionally observed.
There are data on isolated cases of very acute anaphylactic reactions, however their communication with reception of Ambroxol is not proved.

Interaction with other medicines:

Abrol together with antibiotics (amoxicillin, tsefuroksy, erythromycin, doxycycline) leads drug use to formation of high concentration of antibiotics in tissues of lungs. There are no messages of rather clinically undesirable interactions with other medicines. Simultaneous use with the medicines having antibechic activity is not recommended (for example, kodeinsoderzhashchy antibechic drugs).

Contraindications:

Hypersensitivity to Ambroxol or other components of drug.

Overdose:

There are no messages concerning overdose symptoms at people today. In case of exceeding of a therapeutic dose the symptomatic treatment is necessary.

Storage conditions:

To store in the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

On 10 tablets in the blister; on 2 blisters in packaging.