Pyridoxine

General characteristics. Structure:

Tablets of white color of a ploskotsilindrichesky form with a facet and risky. The insignificant mramornost is allowed.

Pharmacological properties:

B6 vitamin, participates in a metabolism; it is necessary for normal functioning of the central and peripheral nervous system. Coming to an organism, it is phosphorylated, turns into piridoksal-5-phosphate and is a part of the enzymes which are carrying out decarboxylation and interamination of amino acids. Participates in exchange of tryptophane, methionine, cysteine, glutaminic , etc. amino acids. Plays an important role in exchange of a histamine. Contributes to normalization of lipidic exchange. The isolated deficit of a pyridoxine occurs very seldom, mainly at the children who are on special artificial nutrition (it is shown by diarrhea, spasms, anemia, the peripheral neuropathy can develop).

Indications to use:

Hypo - and B6 avitaminosis (treatment and prevention). In complex therapy: diseases of a nervous system (neuralgia, Menyer's syndrome); In dermatology: seboreepodobny and not seborrheal dermatitis, shingles, neurodermatitises, psoriasis, exudative diathesis and other diseases; Toxicosis of pregnant women: anemias (hypochromia, microcytic, sideroblastny); Acute and chronic hepatitises. Drug increases a diuresis and strengthens effect of diuretics. A pyridoxine the hydrochloride warns or reduces toxic manifestations, including damages of a liver which are observed at use of an isoniazid and other antitubercular drugs.

Route of administration and doses:

The daily need for a pyridoxine for adult men and women makes 2 mg, for children and teenagers depending on age of 0,4 — 2 mg. For prevention of B6 hypovitaminosis appoint the adult 2–5 mg a day, to children — on 2 mg a day.

Inside drug is used after food. Medical doses at intake make for adult 50 - 100 mg 1–2 times a day; for children the dose is reduced according to age. The course of treatment makes 1–2 months. At use of an isoniazid, Ftivazidum or other derivatives of hydrazide of isonicotinic acid it is reasonable to appoint a pyridoxine on 5–10 mg a day preventively (for the prevention of disturbances of functions of the central nervous system). For treatment of sideroblastny anemia appoint inside 100 mg daily. It is reasonable to accept at the same time folic acid, cyanocobalamine, Riboflavinum.

Features of use:

At a serious illness of a liver the pyridoxine in high doses can cause deterioration in its function. When determining urobilinigen by means of Ehrlich's reagent can distort results.

Side effects:

Allergic reactions (skin rashes , etc.), hypersecretion of hydrochloric acid.

Interaction with other medicines:

The pyridoxine a hydrochloride is not appointed together with L-dofa (levodopa) as action of the last is weakened. Strengthens effect of diuretics. Isonicotine hydrazide, Penicillaminum, Cycloserinum and estrogensoderzhashchy oral contraceptives weaken effect of a pyridoxine.

Contraindications:

Hypersensitivity to drug components.

With care: A peptic ulcer of a stomach and duodenum ( in connection with possible increase in acidity of a gastric juice), coronary heart disease, severe damages of a liver.

Storage conditions:

Period of validity 3 years. Not to use after the period of validity specified on packaging. In dry, protected from light, the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

On 50 tablets in banks of light-protective glass or in banks polymeric, or bottles polymeric. On 10 tablets in a blister strip packaging or bezjyacheykovy packaging. Each can or a bottle, or 1, 2, 3, 4 or 5 blister strip packagings together with  the application instruction are placed in a pack from a cardboard. It is allowed banks polymeric or bottles polymeric without packs, to place planimetric bezjyacheykovy packagings with the equal number of application instructions in group packaging.