Pyridoxine of / хл 5%vitv6 N10

General characteristics. Structure:

International and chemical names: pyridoxine, (5-hydroxy-6-methylpyridin-3,4-diil) - dimethanol a hydrochloride); main physical and chemical properties: transparent, colourless or with slightly yellowish shade liquid; structure: 1 ml of solution contains a pyridoxine of a hydrochloride 50 mg; excipients: water for injections.

Pharmacological properties:

Pharmacodynamics. Drug of water-soluble B6 vitamin. Plays an important role in a metabolism; it is necessary for normal functioning of the central and peripheral nervous system. The pyridoxine in a fosforilirovanny form is a coenzyme of many enzymes which are carrying out processes of decarboxylation and interamination of amino acids. Actively participates in metabolism of tryptophane, methionine, cysteine, glutaminic and other amino acids, exchange of a histamine, a lipometabolism, normalizes lipidic exchange at atherosclerosis, raises a diuresis, exponentiates effect of diuretics.

Pharmacokinetics. It is metabolized in a liver with formation pharmacological of active metabolites - pyridoxal phosphate and a piridoksaminofosfat. It is distributed preferential in muscles, a liver and TsNS. Gets through a placenta and into breast milk. It is removed by kidneys (at intravenous administration with bile about 2% are removed).

Indications to use:

Hypo - and B6 avitaminosis, toxicosis of pregnant women, atherosclerosis, anemia (including sideroblastny), a leukopenia of various genesis, a disease of a nervous system (radiculitis, neuritis, neuralgia, parkinsonism, Littl's disease), an involutional depression, acute and chronic hepatitis, seboreepodobny and not seborrheal dermatitis, shingles, neurodermatitises, psoriasis, exudative diathesis, air and seasickness, Menyer's disease; for reduction of toxic effects of antitubercular drugs.

Route of administration and doses:

Enter intramusculary, intravenously or subcutaneously, especially if because of disturbance of absorption in intestines administration of drug is inside impossible.
Parenterally at all specified ways of introduction the daily dose for adults makes 0,05-0,1 g. For children the dose is appointed by the doctor individually and use other drug of B6 vitamin with a smaller dosage.
The course of treatment makes 30 days.
At parkinsonism intramusculary enter 2 ml of 5% of solution a day. A course of treatment – 20-25 days, in 2-3 months conduct a repeated course. According to other scheme of treatment of this disease of 5% solution is entered intramusculary, in an initial daily dose of 50-100 mg, and then daily the dose is raised on 50 mg and brought to 300-400 mg a day, once. Therapy at the same time is performed by courses of 12-15 days.
For treatment of an involutional depression the drug is administered intramusculary, in a dose of 200 mg a day.
At therapy of sideroblastny anemia the drug is administered intramusculary, 0,1 g, 2 times a week (reception of folic acid, Riboflavinum, B12 vitamin is at the same time recommended).

Features of use:

At severe damages of a liver the pyridoxine in high doses can cause deterioration in its function.
With care apply at a peptic ulcer of a stomach and duodenum, coronary heart disease.

Side effects:

Allergic reactions (skin rash, small tortoiseshell) are possible. Also separate cases of an acute anaphylaxis after 1-2 injections of a pyridoxine are described.

Interaction with other medicines:

Not to appoint along with a levodopa since the pyridoxine weakens action of the last. Not to mix in one syringe with solutions of B1 and B12 vitamins. Hormonal contraceptives, гидралазин, Penicillaminum increase the need for a pyridoxine. Drug reduces neurotoxic action of an isoniazid, and also eliminates side effects of tricyclic antidepressants, apressine, cyclosporine, lowers the level of phenobarbital, dipheninum in blood.
It is effective at prolonged use of levomycetinum for the prevention of ophthalmologic complications. The pyridoxine increases a diuresis and strengthens effect of diuretics.
At patients with chronic heart failure drug exponentiates effect of cardiac glycosides.

Contraindications:

Hypersensitivity to drug.

Overdose:

Symptoms: strengthening of side effects (allergic reactions: skin rash, small tortoiseshell, acute anaphylaxis).
Treatment: drug withdrawal, symptomatic therapy.

Storage conditions:

To store in protected from light and the place, unavailable to children, at a temperature not above 25 °C.
Period of validity - 3 years.

Issue conditions:

According to the recipe

Packaging:

Solution for injections of 5%, on 1 ml in ampoules No. 10.