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Tsinarizin-LH tab.0,025 No. 50

Препарат Цинаризин-ЛХ таб.0,025 № 50. ЗАО "Лекхим-Харьков" Украина

Producer: CJSC Lekhim-Kharkiv Ukraine

Code of automatic telephone exchange: N07C A02

Release form: Firm dosage forms. Tablets.

Indications to use: Disturbance of cerebral circulation. Spasm of blood vessels (vasomotor spasm). Atherosclerosis. Hemorrhagic stroke. Distsirkulyatorny encephalopathy. Migraine. Menyer's disease. Raynaud's disease. Diabetic angiopatiya.

General characteristics. Structure:

International and chemical name: cinnarizine; [(Е) - 1-difenilmetil-4-(3-phenyl-2-propenyl) - piperazin]; Main physical and chemical properties: tablets of white or almost white color. Structure: 1 tablet contains cinnarizine 0,025 g; excipients: lactoses monohydrate, potato starch, magnesium stearate, silicon dioxide colloid (aerosil), polyvinylpirrolidone low-molecular medical.

Pharmacological properties:

Pharmacodynamics. The drug Tsinnarizin-LH improves cerebral, peripheric and coronary circulation. Has a high tropnost to brain vessels. Drug inhibits receipt in a cell and reduces keeping in depot of its plasmolemma of calcium ions that is more connected with blockade of membrane calcium channels by it. Reduces a tone of smooth muscles of arterioles, directly influencing smooth muscles of vessels, reduces reactions to biogenic vasoconstrictive substances (adrenaline, noradrenaline, ангиотензн), increases resistance of fabrics to a hypoxia. Has moderate antihistaminic activity, reduces excitability of a vestibular mechanism, lowers a sympathetic tone. Does not influence the system arterial pressure, conductivity, contractility of heart, frequency of reductions of the last.

Pharmacokinetics. The maximum concentration in a blood plasma after intake is reached in 1–3 h at an elimination half-life about 4 hours. 91% contact proteins of a blood plasma. It is completely metabolized in a liver by means of dealkylation. 2/3 metabolites are allocated with a stake, 1/3 – with urine.

Indications to use:

Drug is used at the disturbances of cerebral circulation caused by an ischemic stroke, a vasospasm, atherosclerosis in the period of an aftercare of a hemorrhagic stroke and craniocereberal injuries, at distsirkulyatorny encephalopathy, migraine, Menyer's disease, for prevention and treatment of disturbances of peripheric circulation (an obliterating thromboangitis, a Raynaud's disease, a diabetic angiopatiya, a Crocq's disease), cerebrovascular insufficiency (dizziness, a sonitus, decrease in concentration of attention and memory), prevention of a disease of movement.

Route of administration and doses:

Drug is appointed inside after food. At disturbance of cerebral circulation of cerebrovascular insufficiency usually apply on 1 tablet (25 mg) 3 times a day or 3 tablets (75 mg) once a day. At disturbances of peripheric circulation appoint 2-3 tablets 3 times a day or 3 tablets (25 mg) once a day. If necessary before movement in any transport take 1 pill (25 mg) in 30 minutes, at vestibular frustration the dose is raised to 1 tablet (25 mg) by 3 times a day. To children the dose is reduced twice. The course of treatment makes several weeks or months.

Features of use:

It is necessary to consider drug sedation (especially in the first days of treatment) at appointment to drivers of transport and other persons whose work demands bystry mental and physical reaction. At prolonged treatment control of functions of a liver, kidneys is necessary, for peripheral blood. With care to apply at Parkinson's disease.

Side effects:

Drowsiness, weakness, fatigue, headache, dryness in a mouth, hypotension, cholestatic jaundice, the increased sweating are possible, or flat depriving of manifestation of a lupus erythematosus, the dispepsichesky phenomena, allergic reactions in the form of skin rash. At elderly people extrapyramidal symptoms, a depression appear or amplify. In such cases it is necessary to reduce a drug dose.

Interaction with other medicines:

Drug strengthens effect of sedatives, alcohol, tricyclic antidepressants, nootropic means, the means expanding vessels.


Hypersensitivity to drug components. Drug is not recommended to pregnant women and in the period of a lactation.


Symptoms: vomiting, drowsiness, tremor, arterial hypotension, coma. Treatment: gastric lavage, purpose of absorbent carbon; symptomatic therapy. There is no specific antidote.

Storage conditions:

In the dry, protected from light place at a temperature from 15 °C to 25 °C.

Period of validity – 5 years.

Issue conditions:

Without recipe


On 25 tablets in blister strip packagings, on 1 or 2 blister strip packagings in a pack cardboard.

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