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medicalmeds.eu Medicines Antifungal means. Candide

Candide

Препарат Кандид. Glenmark Pharmaceuticals Ltd.(Гленмарк Фармасьютикалз Лтд) Индия


Producer: Glenmark Pharmaceuticals Ltd. (Glenmark Pharmasyyutikalz Ltd) India

Code of automatic telephone exchange: G01AF02

Release form: Soft dosage forms. Gel.

Indications to use: Vulvovaginitis. Trichomoniasis.


General characteristics. Structure:

Active agent: Clotrimazolum of 20 mg

Excipients: cetyl alcohol, propylene glycol, глицерол (glycerin), benzyl alcohol, tsetomakrogolny emulsion wax, карбопол 940 (carbomer 940), sodium hydroxide, chlorocresol, the water purified.




Pharmacological properties:

Candide is antifungal broad-spectrum agent for topical administration. The anti-mycotic effect of active active ingredient of Clotrimazolum (derivative an imidazole) is connected with disturbance of synthesis of the ergosterol which is a part of a cellular membrane of mushrooms that changes permeability of a membrane and causes the subsequent lysis of a cell. In small concentration affects fungistaticly, and in big - fungitsidno, and not only proliferating cells. In fungicidal concentration interacts with mitochondrial and peroksidazny enzymes therefore there is an increase in concentration of peroxide of hydrogen up to toxic level that also promotes destruction of fungal cells.
It is effective concerning dermatophytes, drozhzhepodobny and mold mushrooms, and also the activator multi-colored depriving (Pityriasis versicolor) and the activator of an erythrasma. Has antimicrobic effect concerning gram-positive (staphylococcus, streptococci) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), and also concerning Trichomonas vaginalis.

Pharmacokinetics. At intravaginalny use absorption of Clotrimazolum makes 3-10% of the entered dose. High concentration in a vaginal secret and low concentration in blood remain within 48-72 hours. In a liver it is quickly metabolized to inactive metabolites.


Indications to use:

- the genital infections caused by drozhzhepodobny mushrooms of the sort Candida and/or Trichomonas vaginalis (a candidosis vulvovaginitis, trichomoniasis);
- the genital superinfections caused by the microorganisms sensitive to Clotrimazolum.


Route of administration and doses:

Locally. Only for intravaginalny use.
The full applicator with gel (about 5 g of drug) is entered in the evening into a vagina, in a dorsal decubitus at slightly bent legs daily within 6 days. The repeated course of treatment is possible after consultation of the doctor.


Features of use:

Prevention of urogenital reinfection requires simultaneous treatment of sexual partners. At trichomoniasis together with Kandid it is necessary to apply other medicines possessing systemic action to more successful treatment (for example, metronidazole inside). During pregnancy treatment by vaginal gel should be carried out without applicator.
At patients with a liver failure it is necessary to control a functional condition of a liver periodically.
At emergence of signs of hypersensitivity or irritation treatment is stopped. To avoid hit of drug on a mucous membrane of eyes.
Not to use drug in the period of periods.
In the absence of effect within 4 weeks it is necessary to confirm the diagnosis.


Side effects:

Itch, burning, hyperemia and hypostasis of a mucous membrane of a vagina; allocations from a vagina, a headache, a gastralgia, the speeded-up urination, intercurrent cystitis, a burning sensation in a penis at the sexual partner, a colpodynia during sexual intercourse.


Interaction with other medicines:

At vaginal introduction Clotrimazolum reduces activity of Amphotericinum In and other half-yen antibiotics. At simultaneous use with natamitsiny and nystatin activity of Clotrimazolum can decrease.


Contraindications:

Hypersensitivity to Clotrimazolum or excipients, the menstrual period, the I trimester of pregnancy.

With care - the lactation period.

Use during pregnancy and in the period of a lactation
At clinical and pilot studies it was not established that use of drug during pregnancy or during feeding by a breast exerts negative impact on health of the woman or a fruit (child). However the issue of expediency of purpose of drug has to be resolved individually after consultation of the doctor.


Overdose:

Use of drug in the raised doses does not cause any reactions and states, life-threatening.


Storage conditions:

In the place protected from light, at a temperature not above 25 °C.
Not to freeze.
In the place, unavailable to children.


Issue conditions:

Without recipe


Packaging:

Vaginal gel of 2% in aluminum tubas on 30 g. The tuba complete with the applicator and the application instruction is placed in a pack from a cardboard.



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