Candide (solution for external use of 20 ml)

General characteristics. Structure:

Active agent: Clotrimazolum of 10,0 mg

Excipients: propylene glycol 990,0mg.

Pharmacological properties:

Pharmacological action - antifungal broad-spectrum agent for topical administration, antibacterial, antiprotozoan, trikhomonatsidny. The anti-mycotic effect of active active ingredient of Clotrimazolum (derivative an imidazole) is connected with disturbance of synthesis of the ergosterol which is a part of a cellular membrane of mushrooms that changes permeability of a membrane and causes the subsequent lysis of a cell. In small concentration affects fungistaticly, and in big - fungitsidno, and not only proliferating cells. In fungicidal concentration interacts with mitochondrial and peroksidazny enzymes therefore there is an increase in concentration of peroxide of hydrogen up to toxic level that also promotes destruction of fungal cells.
Shows fungicidal and fungistatic activity concerning dermatomitset (Trichophyton rubrum, Trychophyton mentagrophytes, Epidermophyton flocossum, Microsporum canis), drozhzhepodobny and mold mushrooms (Candida spp., including Candida albicans; Torulopsis glabrate, sorts Rhodotorula, Pityrosporum orbiculare). It is active in the relation возбудтьеля multi-colored depriving – Pityrosporum orbiculare (Malassezia furfur). It is effective concerning gram-positive bacteria – Corynebacterium minutissimum erythrasma activator, and also Staphylococcus spp., Streptococcus spp., gram-negative bacteria – Bacteroides, Gardnerella vaginalis. In high concentration it is active concerning Trichomonas vaginalis.

Pharmacokinetics. Clotrimazolum is badly soaked up through skin and mucous membranes and has practically no systemic action. At external use concentration of Clotrimazolum in epidermis is higher, than in a derma and hypodermic cellulose.

Indications to use:

- fungus diseases of skin, mycoses of skin folds, feet;
- the chromophytosis, an erythrasma, superficial candidiases caused by dermatophytes, barmy (including the sort Candida), the mold and other mushrooms and activators sensitive to Clotrimazolum;
- the mycoses complicated by a secondary pyoderma.

Route of administration and doses:

Outwardly. Solution is applied with a thin layer by 2 times a day on previously cleared (using soap with neutral value рН) and the dried-up affected areas of skin.
Duration of treatment depends on disease severity, localization of pathological changes and efficiency of therapy. Treatment of dermatomycoses is carried out by not less than 4 weeks, a chromophytosis - 1-3 weeks.
At fungus diseases of skin of legs therapy is recommended to be continued within not less than 2 weeks after elimination of symptoms of a disease.

Features of use:

Putting drug on skin in eyes is not recommended.
At emergence of signs of hypersensitivity or irritation treatment is stopped.
At patients with a liver failure it is necessary to control a functional condition of a liver periodically.
In the absence of effect within 4 weeks it is necessary to confirm the diagnosis.
Only for external use.

Influence on ability to manage vehicles and mechanisms
Drug does not influence ability to manage vehicles and mechanisms.

Side effects:

Itch, burning, pricking in sites of application, emergence of an erythema, blisters, hypostasis, irritation and a peeling of skin. Allergic reactions (itch, urticaria).

With care
Lactation period.

Interaction with other medicines:

Amphotericinum In, nystatin, натамицин reduce efficiency of Clotrimazolum at simultaneous use. At solution use negative interactions with other means are not established and they should not be expected since rezorbtsionny ability of Clotrimazolum very low.

Contraindications:

- Hypersensitivity to Clotrimazolum or other components of drug (propylene glycol, polyethyleneglycol, isopropyl alcohol);
- I trimester of pregnancy.

Use at pregnancy and during breastfeeding
At clinical and pilot studies it was not established that use of drug during pregnancy or during feeding by a breast exerts negative impact on health of the woman or a fruit (child). However the question of expediency of purpose of drug in II and the III trimester has to be solved individually after consultation from a vrachomvrach. At purpose of drug during II or III trimesters of pregnancy it is necessary to consider a ratio of estimated advantage of purpose of drug for mother and possible risk for a fruit.
Putting drug directly on the lactating mammary gland is contraindicated.

Overdose:

Use of solution in the raised doses does not cause any reactions and states, life-threatening.

Storage conditions:

In the place protected from light, at a temperature from 2 °C to 25 °C.
To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

Solution for external use of 1%.
On 20 ml of drug in bottles polyethylene. 1 bottle with the application instruction is placed in a cardboard pack.