The bacteriophage is streptococcal

General characteristics. Structure:

Active ingredients: sterile filtrate of fagolizat of strains of Streptococcus.

Excipient: preservative - 8 hydroxyquinolines of sulfate monohydrate - 0,0001 g/ml (in terms of 8 hydroxyquinolines  sulfate, contents settlement).

Pharmacological properties:

Pharmacodynamics. Drug has ability to lyse specifically Streptococcus bacteria.

Indications to use:

Treatment and prevention of the diseases caused by Streptococcusv bacteria structure of complex therapy:

• diseases of an ear, throat, nose, respiratory tracts and lungs (inflammation of bosoms of a nose, middle ear, quinsy, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy); 
• surgical infections (suppurations of wounds, burns, abscess, phlegmon, furuncles, anthrax, hydradenitis, felons, paraproctitis, mastitis, bursitis, osteomyelitis); 
• urogenital infections (urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingo-oophoritis); 
• enteral infections (gastroenterocolitis, cholecystitis), intestinal dysbiosis; 
• generalized septic diseases; 
• pyoinflammatory diseases of newborns (omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc.); 
• other diseases caused by streptococci.

With the preventive purpose drug is used for processing of postoperative and svezheinfitsirovanny wounds, and also for prevention of intrahospital infections according to epidemic indications.

Important condition of an effective phagotherapy is preliminary definition of a phagosensitivity of the activator.

Route of administration and doses:

Drug is used for intake (through a mouth), rectal administration, applications, irrigations, introduction to cavities of wounds, vaginas, a uterus, a nose, bosoms of a nose and the trained cavities.

The recommended drug dosages:

Treatment of pyoinflammatory diseases with the localized defeats has to be carried out at the same time as locally, and administration of drug inside within 7-20 days (according to clinical indications).

If before use of a bacteriophage chemical antiseptic agents were applied to treatment of wounds, the wound has to be washed carefully out sterile 0,9% by chloride sodium solution.

Depending on the infection center the bacteriophage is applied:

1. In the form of irrigation, lotions and packing in volume to 200 ml depending on the sizes of an affected area. At abscess after removal of purulent contents by means of a puncture the drug is administered in quantity smaller, than the volume of remote pus. At osteomyelitis after the corresponding surgical treatment in a wound pour in a bacteriophage on 10-20 ml.
2. At introduction to cavities (pleural, joint and other limited cavities) to 100 ml then leave a capillary drainage through which the bacteriophage is entered within several days.
3. At cystitis, pyelonephritises, uretrita drug is accepted inside. If the cavity of a bladder or a renal pelvis are trained, the bacteriophage is entered through tsistosty or nefrosty 1-2 once a day on 20-50 ml into a bladder and on 5-7 ml in a renal pelvis.
4. At pyoinflammatory gynecologic diseases the drug is administered in a cavity of a vagina, a uterus in a dose of 5-10 ml daily once, at a colpitis - on 10 ml irrigation or packing 2 times a day. Tampons put for 2 hours.
5. At pyoinflammatory diseases of an ear, throat, nose the drug is administered in a dose 2-10 ml by 1-3 times a day. The bacteriophage is used for rinsing, by washings, instillations, introduction of the moistened turundas (leaving them for 1 hour).
6. At enteral infections, an intestinal dysbiosis drug is taken inside by 3 times a day for 1 h before meal. The combination of double intake to single rectal administration one-time age a dozybakteriofaga in the form of an enema after bowel emptying is possible.

Use of a bacteriophage for children (up to 6 months). At sepsis, a coloenteritis of newborns, including premature children, the bacteriophage is applied in the form of high enemas (through a colonic tube or a catheter) by 2-3 times a day in a dose of 5-10 ml. In the absence of vomiting and vomiting use of drug through a mouth is possible. In this case it mixes up with breast milk. The combination rectal (in the form of high enemas) and peroral (through a mouth) drug uses is possible. Course of treatment of 5-15 days. At the recurrent course of a disease carrying out repeated courses of treatment is possible. For the purpose of prevention of sepsis and a coloenteritis at pre-natal infection or danger of developing of an intrahospital infection at newborn children the bacteriophage is applied in the form of enemas by 2 times a day within 5-7 days.

At treatment of an omphalitis, pyoderma, contaminated wounds drug is used in the form of applications daily twice (the gauze napkin is moistened with a bacteriophage and impose on an umbilical wound or an affected area of skin).

Features of use:

Before use the bottle with a bacteriophage needs to be shaken up and seen. Drug has to be transparent and not contain a deposit.

Attention! At opacification not to use drug!

Owing to the content in drug of a medium in which bacteria from the environment can develop, causing drug opacification, it is necessary to follow the following rules when opening a bottle:

• to carefully wash hands;
• to process a cap alcohol-containing solution;
• to remove a cap, without opening a stopper;
• not to put a stopper an internal surface on a table or other objects;
• not to leave a bottle open;
• to store the opened bottle only in the refrigerator.

Opening of a bottle and extraction of necessary volume of drug can be carried out by the sterile syringe by a stopper puncture.

Drug from the opened bottle at observance of storage conditions, above-mentioned rules and lack of opacification can be used during all period of validity.

Use at pregnancy and during breastfeeding. Use of this medical supply at pregnancy and during feeding by a breast perhaps in the presence of the infections caused by fagochuvstvitelny strains of streptococci (according to the recommendation of the doctor).

Side effects:

Are not established.

Interaction with other medicines:

Use of a bacteriophage does not exclude use of other antibacterial drugs.

Contraindications:

Hypersensitivity to drug components.

Storage conditions:

Period of validity - 2 years. In the dry, protected from light place, at a temperature of 2-10 °C. To store in the place, unavailable to children. To store the opened bottle only in the refrigerator. Drug from the opened bottle at observance of storage conditions, above-mentioned rules and lack of opacification can be used during all period of validity.

Issue conditions:

Without recipe

Packaging:

Solution for intake, topical and external use on 20, 100 ml in bottles. 4 or 10 bottles on 20 ml or 1 bottle on 100 ml in a pack from a cardboard.