Sekstafag® Piobakteriofag polyvalent

General characteristics. Structure:

Active ingredients: sterile filtrate of fagolizat of bacteria of Staphylococcus, Streptococcus, Proteus (P. vulgaris, P. mirabilis), Pseudomonas aeruginosa, enteropathogenic Escherichia coli, Klebsiella pneumoniae.

Excipients: Sulfate hydroxyquinoline preservative 8 monohydrate - 0,0001 g/ml (contents settlement).

Pharmacological properties:

Pharmacodynamics. Пиобактериофаг polyvalent has ability to lyse specifically bacteria of stafilokokk, streptococci (including enterococci), a protea, клебсиелл pneumonia, pyocyanic and intestinal sticks.

Indications to use:

Treatment and prevention of the pyoinflammatory and enteral diseases caused by stafilokokka, streptococci, proteas, klebsiyella, pyocyanic and intestinal sticks:

• diseases of an ear, a throat, a nose, respiratory tracts and lungs – inflammations of bosoms of a nose, a middle ear, quinsy, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy;
• surgical infections – suppuration of wounds, burns, abscess, phlegmon, furuncles, an anthrax, a hydroadenitis, felons, a paraproctitis, mastitis, a bursitis, osteomyelitis;
• urogenital infections – an urethritis, cystitis, pyelonephritis, a colpitis, an endometritis, a salpingo-oophoritis;
• posttraumatic konjyuktivita, keratokonjyuktivita, purulent helcomas and iridocyclites;
• enteral infections – a gastroenterocolitis, cholecystitis, dysbacteriosis;
• generalized septic diseases;
• pyoinflammatory diseases of newborns – the omphalitis, a pyoderma, konjyuktivit, a gastroenterocolitis, sepsis, etc.;
• other diseases caused by bacteria of stafilokokk, streptococci (including enterococci), a protea, клебсиелл pneumonia, pyocyanic and intestinal sticks.

At heavy displays of the infections caused by stafilokokka, streptococci, Proteus, klebsiyelly pneumonia, pyocyanic and intestinal sticks, drug is appointed as a part of complex therapy.

With the preventive purpose drug is used for processing of operational and svezheinfitsirovanny wounds, and also for prevention of intrahospital infections according to epidemic indications.

Important condition of an effective phagotherapy is preliminary definition of a phagosensitivity of the activator.

Route of administration and doses:

Before use the bottle with a bacteriophage needs to be shaken up and seen. Drug has to be transparent and not contain a deposit.

Attention! At opacification not to use drug!

Owing to the content in drug of a medium in which bacteria from the environment can develop, causing drug opacification, it is necessary to follow the following rules when opening a bottle:

• to carefully wash hands;
• to process a cap alcohol-containing solution;
• to remove a cap, without opening a stopper;
• not to put a stopper an internal surface on a table or other objects;
• not to leave a bottle open;
• to store the opened bottle only in the refrigerator.

When using small doses (2-8 drops) drug needs to be selected the sterile syringe of 0,5 - 1 ml.

Drug from the opened bottle at observance of storage conditions, above-mentioned rules and lack of opacification can be used during all period of validity.

Treatment of pyoinflammatory diseases with the localized defeats has to be carried out at the same time as locally, and administration of drug inside within 7-20 days (according to clinical indications).

Depending on character of the center of an infection the bacteriophage is applied:

1. Locally in the form of irrigation, lotions and packing by a liquid phage in quantity to 200 ml depending on the sizes of an affected area. At abscesses the bacteriophage is entered into a center cavity after removal of pus by means of a puncture. The amount of the administered drug has to be slightly less than the volume of remote pus. At osteomyelitis after the corresponding surgical treatment in a wound pour in a bacteriophage on 10-20 ml.
2. Introduction to cavities – pleural, joint and other limited cavities to 100 ml of a bacteriophage then leave a capillary drainage through which within several days repeatedly enter a bacteriophage.
3. At cystitis, pyelonephritises, uretrita drug is accepted inside. If the cavity of a bladder or a renal pelvis are trained, the bacteriophage is entered through tsistosty or nefrosty 1-2 once a day on 20-50 ml into a bladder and on 5-7 ml in a renal pelvis.
4. At pyoinflammatory gynecologic diseases the drug is administered in a cavity of a vagina, a uterus in a dose of 5-10 ml daily once.
5. At pyoinflammatory diseases of an ear, throat, nose the drug is administered in a dose 2-10 ml by 1-3 times a day. The bacteriophage is used for rinsing, by washings, instillations, introductions of the moistened turundas (leaving them for 1 hour).
6. At konjyuktivita and keratokonjyuktivita drug is dug in on 2-3 drops of 4-5 times a day, at a purulent helcoma – on 4-5 drops, at purulent iridocyclites drug is used on 6-8 drops by each 3 hours in combination with intake.
7. At treatment of stomatitises and chronic generalized parodontit drug 3-4 times a day in a dose use in the form of rinsings of an oral cavity 10-20 ml, and also introduction to parodontalny pockets of the turundas impregnated piobakteriofagy for 5-10 minutes.
8. At intestinal forms of a disease, diseases of internals, dysbacteriosis the bacteriophage is applied through a mouth and in the form of enemas within 7 - 20 days. Through a mouth 3 times a day on an empty stomach in 1 hour prior to food give a bacteriophage. In the form of enemas appoint instead of one reception through a mouth once a day.

The recommended drug dosages:

If before use of a bacteriophage chemical antiseptic agents were applied to treatment of wounds, the wound has to be washed carefully out sterile 0,9% by chloride sodium solution.

Use of a bacteriophage for children (up to 6 months). At sepsis, a coloenteritis of newborns, including premature children, the bacteriophage is applied in the form of high enemas (through a colonic tube or a catheter) by 2-3 times a day (see the tab.). In the absence of vomiting and vomiting use of drug through a mouth is possible. In this case it mixes up with breast milk. The combination rectal (in enemas) and peroral (through a mouth) drug uses is possible. Course of treatment of 5-15 days. At the recurrent course of a disease carrying out repeated courses of treatment is possible. For the purpose of prevention of sepsis and a coloenteritis at pre-natal infection or danger of developing of an intrahospital infection at newborn children the bacteriophage is applied in the form of enemas by 2 times a day within 5-7 days.

At treatment of omphalites, pyodermas, contaminated wounds drug is used in the form of applications daily twice (the gauze napkin is moistened with a bacteriophage and impose on an umbilical wound or on an affected area of skin).

Features of use:

Before the use the bottle with a liquid bacteriophage needs to be shaken up. At opacification not to use!

Use at pregnancy and during breastfeeding. Use of drug at pregnancy and during breastfeeding in the presence of the infections caused by fagochuvstvitelny strains of bacteria is reasonable (according to the recommendation of the doctor).

Side effects:

Are not revealed.

Interaction with other medicines:

Use of drug is possible in combination with other medicines, including with antibiotics.

Contraindications:

No.

Storage conditions:

Period of validity - 2 years. In the dry, protected from light place, at a temperature of 2-10 °C. To store in the place, unavailable to children. To store the opened bottle only in the refrigerator. Drug from the opened bottle at observance of storage conditions, above-mentioned rules and lack of opacification can be used during all period of validity.

Issue conditions:

Without recipe

Packaging:

Solution for intake, topical and external use. on 20 ml in bottles. 4 or 10 bottles on 20 ml in a pack from a cardboard together with the application instruction.