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medicalmeds.eu Medicines The antibiotic combined (penicillin semi-synthetic). Ampicillini trihdras

Ampicillini trihdras

Препарат Ампициллина тригидрат. РУП "Белмедпрепараты" Республика Беларусь


Producer: RUP of Belmedpreparata Republic of Belarus

Code of automatic telephone exchange: J01CA01

Release form: Firm dosage forms. Tablets.

Indications to use: Pneumonia. Bronchial pneumonia. Abscess of lungs. Peritonitis. Sepsis. Quinsy (Acute tonsillitis). Pyelitis. Cystitis. Cholangitis. Cholecystitis. Digestive tract infections. Salmonellosis.


General characteristics. Structure:

Active ingredient: 250 mg of Ampicillini trihdras in 1 tablet.

Excipients: starch, magnesium stearate, talc.

The semi-synthetic penicillinic antibiotic possessing antibacterial (bactericidal) action.




Pharmacological properties:

Pharmacodynamics. Ampicillini trihdras — an antibiotic of group of semi-synthetic penicillin. Possesses antibacterial (bactericidal) action. It is active concerning a wide range gram-positive (alpha and beta and hemolitic streptococci, Streptococcus pneumoniae, Staphylococcus spp., except for the strains producing a penicillinase, Bacillus anthracis, Clostridium spp., Enterococcus spp.) and gram-negative (Haemophilus influenzae, Neisseria meningitidis, Neisseria gonorrhoeae, Salmonella spp., Proteus mirabilis, Listeria monocytogenes, Shigella spp., Escherichia coli, Bordetella pertussis) microorganisms.

Collapses a penicillinase and therefore does not affect penitsillinazoobrazuyushchy strains of activators.

Pharmacokinetics. In digestive tract 40 — 60% of the accepted dose are soaked up. The maximum concentration in blood is reached in 1,5 — 2 h after reception. Gets into fabrics and biological liquids of an organism. Does not collapse in acid medium of a stomach. It is removed preferential by kidneys in not changed look.

In urine high concentration of not changed antibiotic are created. It is partially excreted with bile, at nursing mothers — with milk. At repeated introductions does not kumulirut that gives the chance to apply Ampicillini trihdras it is long.


Indications to use:

Ampicillini trihdras is applied at pneumonia, bronkhopnevmoniya, abscesses of lungs; peritonitis; sepsis; to quinsy; infections, including mixed, urine - and biliary tract (a pyelitis, pyelonephritis, cystitis, a cholangitis, cholecystitis); digestive tract infections, including salmonellezonositelstvo; infections of the soft tissues and other diseases caused by microorganisms, sensitive to action of an antibiotic.


Route of administration and doses:

Ampicillini trihdras is applied inside irrespective of meal. The single dose for adults makes 0,5 g, daily — 2 — 3 g. To children is aged more senior than 1 month appoint 100 mg/kg in a daily dose. The daily dose is divided into 4 — 6 receptions. Duration of treatment is established individually depending on weight and a form of a disease (of 5 — 10 days to 2 — 3 weeks and more).


Features of use:

In the course of treatment by Ampicillini trihdras systematic control of function of a liver, kidneys and a picture of peripheral blood is necessary. Patients with renal failures need correction of the mode of dosing according to values of clearance of creatinine. At use of high doses of drug for patients with a renal failure perhaps toxic action on the central nervous system.

At bronchial asthma, hay fever and other allergic states at the same time appoint the desensibilizing means. At a liver failure Ampicillini trihdras is used under control of a functional condition of a liver.


Side effects:

Allergic reactions (a small tortoiseshell, an erythema, a Quincke's edema, rhinitis, conjunctivitis, it is rare — fever, joint pains, an eosinophilia, it is extremely rare — an acute anaphylaxis), nausea, vomiting, intestinal dysbacteriosis, the colitis caused by S. difficale, oral cavity candidiasis, vaginal candidiasis.


Interaction with other medicines:

Ampicillini trihdras reduces effect of oral contraceptives, increases — anticoagulants, antibiotics of an aminoglikozidny row. Allopyrinolum increases probability of emergence of skin rash. Probenetsid at simultaneous use with ampicillin reduces canalicular secretion of the last therefore concentration of ampicillin in a blood plasma increases and the risk of development of toxic action increases.


Contraindications:

The increased individual sensitivity (including to other penicillin, cephalosporins, karbapenema), an infectious mononucleosis, heavy abnormal liver functions, breastfeeding (for the period of treatment it is necessary to suspend).


Overdose:

Symptoms: it is shown by toxic action on the central nervous system (especially at patients with a renal failure).

Treatment: symptomatic (maintenance of the vital functions).


Storage conditions:

To store in the dry, protected from light place at a temperature not above 25 °C. Period of validity 2 years. To store in places unavailable to children. Not to use after expiry date.


Issue conditions:

According to the recipe


Packaging:

Tablets on 250 mg in packaging No. 20 (No. 10х2 in planimetric bezjyacheykovy packaging).



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