Ampicillini trihdras
Producer: JSC Biokhimik Republic of Mordovia
Code of automatic telephone exchange: J01CA01
Release form: Firm dosage forms. Tablets.
General characteristics. Structure:
Active ingredient: 0,25 g of Ampicillini trihdras (in terms of active agent).
Excipients: starch, magnesium stearate, talc.
Pharmacological properties:
Pharmacodynamics. Ampicillini trihdras is active concerning gram-positive and the majority gram-negative (colibacillus, Friedlander and Pfeyffer's sticks. shigellas, salmonellas, proteas) microorganisms. Drug collapses a penicillinase and therefore does not affect penitsillinazoobrazuyushchy strains of microbes.
Pharmacokinetics. Absorption after intake - bystry, high, bioavailability - 40%; TCmax at oral administration of 500 mg is 2 h, Cmax - 3-4 ng/ml.
Communication with proteins of plasma - 20%. It is evenly distributed in bodies and body tissues, it is found in therapeutic concentration in pleural, peritoneal, amniotic and synovial liquids, liquor, contents of blisters, urine (high concentration), a mucous membrane of intestines, bones, a gall bladder, lungs, fabrics of female generative organs, bile, in a bronchial secret (in a purulent bronchial secret accumulation weak), paranasal sinuses, liquid of a middle ear, saliva, fruit fabrics.
Badly gets through GEB (permeability increases at an inflammation). It is removed preferential by kidneys (70-80%), and in urine very high concentration of not changed antibiotic are created; partially with bile, at nursing mothers - with milk. Does not kumulirut. Is removed at a hemodialysis.
Indications to use:
Ampicillini trihdras is appointed at pneumonia, bronchitis, bronkhopnevmoniya, abscesses of lungs, peritonitis, sepsis, quinsy; infections of ENT organs, urine - and biliary tract (a pyelitis, pyelonephritis, cholecystitis), digestive tract, including a salmonellezonositelstvo, infections of the soft tissues and other diseases caused by microorganisms, sensitive to action of an antibiotic. It is effective at treatment of gonorrhea.
Route of administration and doses:
The mode of dosing is set individually depending on weight of a current and localization of an infection, sensitivity of the activator to drug.
Ampicillini trihdras is accepted inside irrespective of meal. The single dose for adults makes 0,25-0,5 g, daily - 1-3 g. To children drug appoint 50-100 mg/kg of body weight in a daily dose. To children with body weight to 20 kg appoint 12,5-25 mg/kg.
The daily dose is divided into 3-4 receptions. Therapy duration is established by Ampicillini trihdras individually depending on weight of a form of a disease and efficiency of treatment.
Contraindications:
Use of Ampicillini trihdras is contraindicated at hypersensitivity to drugs of group of penicillin and other betalaktamny antibiotics.
Storage conditions:
List B. In the dry, protected from light place at a temperature not above 25 °C. In the place, unavailable to children, the Period of validity 2 years. Not to use after the expiry date specified on packaging
Issue conditions:
According to the recipe
Packaging:
Tablets on 0,25 g. On 10 tablets in a blister strip packaging. 2 planimetric packagings together with the application instruction put in a pack from a cardboard.