Platyphyllinum of / т0,2%1мл N10

General characteristics. Structure:

International and chemical names: platyphylline hydrotartrate *; [(1α)-1,2-дигидро-12-гидроксисенеционан-11,16-дион hydrotartrate];
main physical and chemical properties: transparent, colourless liquid;
structure: 1 ml contains hydrotartrate Platyphyllinum (in terms of 100% substance) 2,0 mg; excipients: water for injections.

Pharmacological properties:

Pharmacodynamics. The mechanism of action of Platyphyllinum is caused by blockade M-holinoretseptorov therefore transfer of nervous impulses from the terminations of postganglionic cholinergic fibers on cells of the innervated effector bodies is broken; exerts the direct running-down impact on unstriated muscles. Blocks also N-holinoretseptory vegetative ганглиев (much more weakly).
Drug renders anticholinergic dozozavisimy effect: in smaller doses inhibits secretion of salivary and bronchial glands, sweating, accommodation of eyes, causes a mydriasis, increase in heart rate; in high doses – reduces sokratitelny ability of digestive tract (including biliary tract and a gall bladder) and urinary tract, suppresses gastric secretion.
Holinoblokiruyushchy action is more shown against the background of the raised tone of a parasympathetic part of a nervous system or action M-holinostimulyatorov.
Reducing influence of a vagus nerve, improves conductivity of heart, increases excitability of a myocardium, increases cordial emission. Causes expansion of small vessels of skin. In high doses the vasomotor center oppresses and blocks sympathetic a ganglion owing to what vessels extend and arterial pressure (decreases mainly at intravenous administration). Causes relaxation of smooth muscles of a uterus, bladder and urinary tract; having spasmolytic effect, eliminates a pain syndrome. Relaxes the smooth muscles of bronchial tubes caused by increase in a tone of a vagus nerve or holinostimulyator; increases breath volume, oppresses secretion of bronchial glands.
It is close to atropine on influence on peripheral holinoreaktivny systems, but is less toxic and it is better transferred. In comparison with atropine exerts smaller impact on peripheral M-holinoretseptory, in a smaller measure causes tachycardia (especially at use in high doses) and more weakly oppresses secretion of hemadens.

Pharmacokinetics. Platyphyllinum easily passes through gistogematichesky barriers (including hematoencephalic), cellular and synaptic membranes. At introduction of high doses collects in tissues of the central nervous system in significant concentration. It is metabolized in a liver. It Eliminirutsya by kidneys and intestines.
At the correct use (doses, intervals between introductions) does not kumulirut.

Indications to use:

Spasms of unstriated muscles at a peptic ulcer of a stomach and duodenum, a pylorospasm; cholelithiasis; hepatic, renal and intestinal colic, bronchial asthma (for the prevention bronkho-and a laryngospasm), brain vasospasms; альгодисменорея, a pain syndrome at pancreatitis, a pancreatic coma, dyskinesia of biliary tract, ангиотрофоневроз; arterial hypertension; stenocardia (as a part of a combination therapy). Poisonings with acetone, boric acid, strong acids, arsenic, Reserpinum.

Route of administration and doses:

Appoint subcutaneously.
For stopping of kolikoobrazny abdominal pain, a prolonged attack of bronchial asthma, cerebral and peripheral vasomotor spasms subcutaneously enter 1 – 2 ml of 1 - 2 time a day.
At course treatment subcutaneously enter 1 – 2 ml during 10 – 15 – 20 days of 1 - 2 ml of 1 - 2 time a day.
For vasodilatation and a lowering of arterial pressure intravenous administration is shown.
One-time and daily doses, frequency of introduction are established individually by the doctor depending on indications and age of the patient.

Features of use:

With care apply at diseases of cardiovascular system at which increase in heart rate is undesirable (acute bleeding, a ciliary arrhythmia, tachycardia, etc.), at a thyrotoxicosis (strengthening of tachycardia is possible), at the increased body temperature (its further increase owing to suppression of activity of sweat glands is possible), an achalasia of a gullet and a pyloric stenosis, intestines hypotonia at patients of advanced age or the weakened patients, an open angle glaucoma, toxicosis of pregnant women, injury of a brain at children, a Down syndrome, cerebral palsy.
Use during pregnancy and feeding by a breast. Data on use during pregnancy are absent. In need of use in the period of a lactation breastfeeding should be stopped.
Influence on a possibility of control of vehicles and mechanisms. During treatment it is necessary to abstain from potentially dangerous types of activity demanding concentration of attention and the increased speed of psychomotor reactions.

Side effects:

Dryness in a mouth, thirst, a lowering of arterial pressure, a mydriasis, accommodation disturbance, tachycardia, an intestines atony, dizziness, a headache, photophobia, spasms, an ischuria, acute psychosis (in high doses), a lung atelectasis.

Interaction with other medicines:

Strengthens sedative and somnolent effect of phenobarbital and an etaminal of sodium, blocks effects of a prozerin, increases effects appointed in H2-gistaminolitikov, digoxin and Riboflavinum (slows down a peristaltics and improves absorption). Adrenomimetiki and nitrates exponentiate increase in intraocular pressure.
M-holinoblokatory, амантадин, a haloperidol, фенотиазин, monoamine oxidase inhibitors, tricyclic antidepressants, quinidine sulfate, an isoniazid, some antihistaminic drugs increase risk of development of anticholinergic side effects. Not to apply along with antikholinesterazny drugs.
Morphine strengthens the oppressing action on cardiovascular system, monoamine oxidase inhibitors – positive hrono-and bathmotropic effect, cardiac glycosides – positive bathmotropic action, quinidine, новокаинамид – holinoblokiruyushchy action.
At the pains connected with spasms of smooth muscles, effect of drug is strengthened by analgetics, sedatives, tranquilizers; at vascular spasms – hypotensive and sedatives

Contraindications:

The increased individual sensitivity to Platyphyllinum, closed-angle glaucoma, a cachexia, the expressed atherosclerosis, heart failure of II and III degrees, arrhythmias, tachycardia, a benign hyperplasia of a prostate, a heavy liver and/or renal failure, a piloroduodenalny stenosis, a reflux esophagitis, phrenic hernia in combination with a reflux esophagitis, paralytic impassability or an atony of intestines, bleeding from bodies of digestive tract, the megacolon complicated by ulcer colitis, a myasthenia, advanced and senile age, the pregnancy period, the lactation period, children's age up to 15 years.

Overdose:

Symptoms: paralytic intestinal impassability, an acute ischuria (at patients with a benign hyperplasia of a prostate), accommodation paralysis, increase in intraocular pressure, dryness of a mucous membrane of an oral cavity, nose, throat, swallowing difficulty, a mydriasis (before total disappearance of an iris), a tremor, spasms, a hyperthermia, excitement of the central nervous system with the subsequent its oppression, suppression of the respiratory and vasomotor centers. Treatment: an artificial diuresis, administration of the inhibitors of cholinesterase (a fozostigmin, Galantaminum or a prozerin) weakening paresis of intestines and reducing tachycardia. At moderate excitement and weak spasms – administration of magnesium of sulfate, in hard cases – sodium hydroxybutyrate, an oxygenotherapy, artificial ventilation of the lungs. At life-threatening tachycardia – quinidine sulfate, propranolol.

Storage conditions:

To store in the place protected from light at a temperature from 8 °C to 25 °C. To store in the place, unavailable to children.

Period of validity – 5 years.

Issue conditions:

According to the recipe

Packaging:

Solution for injections of 0,2% on 1 ml in ampoules, No. 10 in the blister folding with a latch in a box; No. 10 in a box.