Drotaverinum

General characteristics. Structure:

International and chemical names: drotaverine; 1-[(3,4 diethoxy-phenyl) methylene] -6,7-диэтокси-1,2,3,4-тетрагидроизохинолина hydrochloride;

main physical and chemical properties: tablets light yellow, light yellow with a greenish shade, color of a round form, yellow or yellow with a greenish shade, with a flat surface, with a facet. On a surface of tablets the mramornost is possible.

structure: 1 tablet contains hydrochloride Drotaverinum, in terms of 100% substance -
0,04 g (40 mg);
excipients: potato starch, granulak-70 (lactoses monohydrate), polyvinylpirrolidone low-molecular medical, calcium stearate.

Pharmacological properties:

Pharmacodynamics. Myotropic spasmolysant. On chemical structure and pharmacological properties it is close to a papaverine, but possesses stronger and long action. Reduces intake of the ionized active calcium in smooth muscle cells at the expense of inhibition of phosphodiesterase and intracellular accumulation of tsAMF. Reduces a tone of unstriated muscles of internals and a peristaltics of intestines, expands blood vessels. Does not influence the autonomic nervous system, does not get through a blood-brain barrier. Increases the minute volume of blood (MVB).

Pharmacokinetics. It is quickly and completely soaked up in digestive tract. At intake bioavailability is close to 100%, the semi-absorption period - 12 minutes. It is evenly distributed on fabrics, gets into smooth muscle cells. It is excreted by kidneys.

Indications to use:

The spasm of smooth muscles of internals (kardio-and a pylorospasm), chronic gastroduodenit, a peptic ulcer of a stomach and a 12-perstny gut, at zhelchekamenny and urolithic diseases (gripes), chronic cholecystitis, a postcholecystectomy syndrome, hyper motor dyskinesia of bilious ways, spastic dyskinesia of intestines, intestinal colic owing to a delay of gases after operation, colitis, a proctitis, tenesmus, a meteorism, a pyelitis, at a headache owing to a brain vasospasm, at a spasm of coronary and peripheral arteries (an obliterating endarteritis, a Raynaud's disease), in need of weakening of reductions of a uterus and for a spasmolysis of a neck of uterus at childbirth, at a spasm of smooth muscles during tool interventions.

Route of administration and doses:

The adult appoint 1 - 2 tablet 2 - 3 times a day. Reception duration depending on the nature of a disease is defined by the doctor. In consecrate with the fact that there are no reliable data of use of drug for children, Drotaverinum is applied exclusively to destination and under observation of the doctor commensurating advantage/risk. To children from 1 year to 6 years appoint 1/2 tablets 1 - 2 times a day; to children of 6 - 12 years - on 1
to tablet 2 - 3 times a day, are more senior than 12 years - on 1-2 tablet 2 - 3 times a day. Children before use should crush and mix a tablet with a small amount of water.

Features of use:

With care it is necessary to appoint drug pregnant, sick with the expressed atherosclerosis of coronary arteries. Drotaverinum can be used as a part of a combination therapy for stopping of hypertensive crisis.
Drotaverinum, like a papaverine, has no anticholinergic effect therefore unlike cholinolytic spasmolysants it can be applied at patients with glaucoma. At the same time at patients with a prostatauxe (prostate adenoma) it is necessary to appoint it with care as in connection with relaxation of a detruzor of a bladder there can be a mocheotdeleniye delay.

Side effects:

Drotaverinum, as a rule, is well transferred. Are sometimes possible: arrhythmia, arterial hypotension, the accelerated heartbeat, allergic dermatitis, a lock, perspiration, feeling of heat.

Interaction with other medicines:

Drotaverinum strengthens effect of other spasmolysants (including M-holinoblokatorov), and also strengthens the hypotension caused by tricyclic antidepressants, quinidine, novokainamidy.
Reliability of elimination of a spasm raises phenobarbital. Drug reduces spazmogenny activity of morphine, antiparkinsonichesky properties of a levodopa.

Contraindications:

Hypersensitivity to Drotaverinum; the expressed liver, renal and heart failure; AV blockade of the II-III degree; cardiogenic shock; arterial hypotension, children's age till 1 year.

Overdose:

At overdose AV blockade, a cardiac standstill, paralysis of a respiratory center are possible. Treatment - symptomatic.

Storage conditions:

To store in the dry, protected from light place at a temperature from 15ºС to 25ºС. A period of validity - 3 years. To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

Tablets on 0,04 g No. 10 in the blister, 1 or 3 blisters.