Ascorutinum

General characteristics. Structure:

Active agents: ascorbic acid of 50,0 mg, routines (in terms of 100% substance) 50,0 mg.

Excipients: starch of 73,0 mg, sugar of 148,7 mg, talc of 5,0 mg, calcium stearate of 3,3 mg.

Pharmacological properties:

Pharmacokinetics. Ascorbic acid is quickly soaked up preferential in duodenal and thin guts (to 50-70% of the accepted dose). In 30 min. after reception the content of ascorbic acid considerably increases in blood, capture begins its fabrics, at the same time it at first will be transformed to dehydroascorbic acid which gets through cellular membranes without metabolic cost and is quickly recovered in a cell. Ascorbic acid is in fabrics almost exclusively intracellularly, is defined in three forms – ascorbic, dehydroascorbic acids and an askorbigen (the combined ascorbic acid) Is distributed between bodies unevenly. Many eë contains in hemadens, especially in adrenal glands, it is less - in a brain, kidneys, a liver, in cordial and skeletal muscles. Content of ascorbic acid in leukocytes and thrombocytes is higher, than in a blood plasma. About 90% by kidneys in the form of oxalate are metabolized and excreted, partially - in a free form it is allocated also with a stake and then. At use of high doses when concentration in a blood plasma reaches more 1,4mg/dl, removal sharply amplifies.

At intake of Rutinum (rutoside) the maximum concentration in blood reaches in 1-4 hours. Rutinum promotes transport and deposition of an ascorbate. It is removed in an invariable look and in the form of metabolites, it is preferential with bile and to a lesser extent, with urine. The elimination half-life makes 10-25ch.

Pharmacodynamics. The combined medicine which effect is caused by effects of the components which are its part. Drug recovers deficit of vitamin C and River.

Ascorbic acid plays an important role in regulation of oxidation-reduction processes, carbohydrate metabolism, coagulability of blood, an angenesis, promotes increase in body resistance.

Rutinum concerns to group of vitamin P. Together with ascorbic acid participates in oxidation-reduction processes, has antioxidant properties, prevents oxidation and promotes deposition of ascorbic acid in fabrics. Eliminates a hyperpermeability of capillaries, strengthens a vascular wall, reducing its puffiness and an inflammation. Possesses antiagregantny action that promotes microcirculation improvement. Both components strengthen a vascular wall (promote formation of intercellular substance, reduce activity of hyaluronidase), reduce permeability and fragility of capillaries.

Rutinum (vitamin P) promotes transformation of ascorbic acid into dehydroascorbic and interferes with further transformation of the last in diketogulonic acid. Therefore the majority of effects of Rutinum is mediated by effect of vitamin C. Rutinum in combination with ascorbic acid reduces permeability and fragility of capillaries, strengthens a vascular wall, reduces aggregation of thrombocytes, has antiinflammatory effect (including due to oppression of activity of hyaluronidase), antioxidant properties, participates in oxidation-reduction processes. Besides, such effects as reduction of exudation of a liquid part of plasma and emigration of blood cells through a vascular wall are inherent to Rutinum; cholagogue and easy anti-hypertensive effects. At patients with chronic venous insufficiency of routines leads to reduction of edematous and painful syndromes, trophic disturbances, reduction or disappearance of paresthesias and spasms. Promotes reduction of expressiveness of side effects of radiation therapy (cystitis, enteroproktit, a dysphagy, a skin erythema), and also slows down progressing of a diabetic retinopathy.

Indications to use:

- hypovitaminosis and avitaminosis With and River.

Treatment and prevention of the diseases and states which are followed by a hyperpermeability and fragility of capillaries:

- hemorrhagic diathesis;

- retinal apoplexies of eyes;

- hemorrhagic vasculitis;

- radial illness;

- septic endocarditis;

- rheumatism;

- glomerulonephritis;

- idiopathic hypertensia;

- arachnoiditis;

- allergic diseases.

As a part of complex therapy:

- a varicosity with painful and edematous syndromes;

- superficial thrombophlebitis;

- trophic disturbances and ulcers;

- chronic venous insufficiency;

- the defeats of capillaries connected using anticoagulants (neodicoumarin, Phenilinum and their analogs), salicylates - with the preventive and medical purpose;

- infectious diseases: measles, scarlet fever.

Route of administration and doses:

For the purpose of prevention by the adult and to teenagers to accept 1-2 tablets a day, to children 3 years – ½-1 are more senior than a tablet in days. The course is defined individually.

With the medical purpose adults and teenagers accept drug on 1-2 tablets 2-3 times a day, children are more senior than 3 years – ½-1 a tablet 2-3 times a day. The mode of dosing depends on the nature of a disease and can change according to the recommendation of the doctor.

Features of use:

Simultaneous use of drug with alkaline drink, the use of fresh fruit or vegetable juice reduces vitamin C absorption. Also, absorption can be broken at enterita.

It is not necessary to appoint high doses of drug the patient with the increased coagulability of blood, thrombophlebitises, tendency to fibrinferments, at a diabetes mellitus (because of the content of ascorbic acid).

At use of high doses of Ascorutinum control of function of kidneys and level of arterial pressure, and also function of a pancreas is necessary.

Drug can change results of laboratory tests to level in blood of bilirubin, glucose, activity of transaminases, lactate dehydrogenases, etc.

High doses of vitamin C are capable to cause abortion from - for increases in synthesis of estrogen. Because of the content in drug of Rutinum it should not be applied in the first trimester of pregnancy. Drug can be used in the period of a lactation.

Does not influence ability to manage the vehicle or potentially dangerous mechanisms.

Side effects:

- allergic reactions;

- headache, hyperexcitability, sleep disorder;

- increase in arterial pressure;

- thrombocytosis, leukocytosis;

- nausea, vomiting, anorexia, pains in epigastric area, enterospasms, diarrhea.

Interaction with other medicines:

Ascorbic acid reduces toxicity of sulfanamide drugs, reduces therapeutic effect of heparin and indirect anticoagulants, promotes digestion of iron, increases penicillin absorption, strengthens side effect of salicylates (risk of emergence of a crystalluria).

Contraindications:

- the increased individual sensitivity to drug components;

- children's age up to 3 years.

Overdose:

Symptoms: nausea, vomiting, diarrhea, headache, increase in arterial pressure, thrombogenesis.

Treatment: gastric lavage, sorbents, symptomatic treatment.

Storage conditions:

To store in the dry, protected from light place, at a temperature not above 30 °C.

To store in the place, unavailable to children!

Issue conditions:

Without recipe

Packaging:

Tablets, in a blister strip packaging of 10 pieces. Planimetric packagings place in boxes from a cardboard together with application instructions.