Dekspantenol

General characteristics. Structure:

Active ingredient: 5 g of a dekspantenol.

Excipients: lanolin anhydrous, cholesterol, vaseline, a liquid paraffin, isopropyl myristate, methylparahydroxybenzoate (нипагин), пропилпарагидроксибензоат (нипазол), the water purified.

Ointment, having the regenerating and easy antiinflammatory effect.

Pharmacological properties:

Pharmacodynamics. Dekspantenol — derivative pantothenic acid. Pantothenic acid — water-soluble vitamin of group B — is a component of a coenzyme of A. Stimuliruyet regeneration of skin, normalizes cellular metabolism, increases durability of collagenic fibers. Increase in need for pantothenic acid is observed at damage of an integument or fabrics, and its shortcoming can be filled with topical administration of a dekspantenol. The optimum molecular weight, hydrophily and a low-polarity do possible its penetration into all layers of skin. Has the regenerating, weak antiinflammatory effect.

Pharmacokinetics. At topical administration quickly is absorbed and turns into pantothenic acid, contacts proteins of plasma (mainly with beta globulin and albumine).

Indications to use:

The disturbances of integrity of an integument caused by mechanical, chemical, thermal factors or after surgical interventions:
- burns of various origin (including solar);
- scratches, grazes, wounds; decubituses; badly beginning to live skin transplants;
- aseptic postoperative wounds;

Inflammatory processes on skin; dermatitis; furuncles; trophic ulcers of the lower extremities; care of skin around trakheosty, gastrostomies and kolosty.

Treatment and prevention of effects of an adverse effect on skin of environmental factors (cold, wind, dampness).

Children have a diaper dermatitis, scratches and insignificant irritation after influence of the sun, ultra-violet and x-ray radiation; treatment and prevention of an intertrigo.

Cracks and inflammations of papillas of the breast at nursing mothers.

It is applied also to processing and protection of dry skin as a source of neutral fats and a dekspantenol.

Route of administration and doses:

Ointment is applied by 2-4 times a day (in need of a thicket). It is applied with a thin layer on an affected area of skin, slightly rubbing. In case of drawing on the infected surface of skin, it should be processed previously any antiseptic agent.

To nursing mothers to grease the surface of a nipple with ointment after each feeding by a breast. To babies apply ointment after each change of linen or a hydrotherapeutic procedure.

Features of use:

Treatment of trophic ulcers and badly beginning to live skin transplants has to is carried out under observation of the attending physician. Not to apply on the becoming wet wounds.

Side effects:

By-effects develop exclusively seldom. Slightly expressed allergic reactions are possible.

Contraindications:

Hypersensitivity to any of drug components.

Storage conditions:

In dry, protected from light, the place, unavailable to children, at a temperature not above 25 °C. Period of validity 2 years. Not to apply after expiry date.

Issue conditions:

Without recipe

Packaging:

Ointment for external use of 5% on 30 g in tubas aluminum or in banks from glass melt. Each tuba or to bank together with the application instruction is placed in a pack from a cardboard.