Piperazin adipate

General characteristics. Structure:

Active agent: piperazin adipate (piperazin adipate) - 500 mg; Excipients: talc, calcium stearate, starch corn, sodium carboxymethylstarch (sodium starch is glikolit).

Pharmacological properties:

Protivogelmintny drug, is effective at an ascaridosis and an enterobiosis. Has the paralyzing effect on a nematode: breaking function of their neuromuscular system, causes muscles paralysis.
Expressiveness of deworming by drug is at the level of 90-95%, and at repeated use can make about 100%. In view of the fact that piperazin does not destroy ascarids, there is no danger of absorption of biological toxic products of their disintegration. Malotoksichen.

Indications to use:

Invasion ascarids (ascaridosis) and pinworms (enterobiosis).

Route of administration and doses:

Inside.
At an ascaridosis to adults and children 15 years are more senior appoint for 1,5 - 2, a daily dose – 3 - 4 g.
To children. Single and daily dose respectively: since 3 years - 0,3 and 0,6 g; 4-5 years - 0,5 and 1 g; 6-8 years - 0,75 and 1,5 g; 9-12 years - 1 and 2 g; 13-15 years - 1,5 and 3 g.
At treatment of an ascaridosis appoint 2 times a day for 1 h or in 0,5-1 h after food within 2 days in a row.
According to other scheme - once (0,4-4 g depending on age) or 2 times on 0,2-2 g.
For treatment of an enterobiosis appoint in the same doses, as at an ascaridosis, within 5 days in a row with 7-day intervals between courses. Conduct 1-3 courses of therapy.
For removal of pinworms from a rectum between courses of treatment for the night give an enema from 1-3 glasses of water, with addition on 1 glass of 1/2 h a spoon of Natrii hydrocarbonas (baking soda).

Features of use:

Piperazin treatment by adipate does not demand a special diet or training of patients.
Laxatives are appointed only at tendency to locks.
During treatment of an enterobiosis observe the high hygienic security.
Treatment can be carried out in out-patient conditions.

Side effects:

Nausea, abdominal pain of spastic character, headache.
Patients with a renal failure have neurotoxic complications (muscular weakness, a tremor, euphoria, hallucinations, deterioration in sight, a lack of coordination of movements).

Interaction with other medicines:

Increases expressiveness of the extrapyramidal disturbances caused by Chlorpromazinum.

Contraindications:

Children aged up to 3 years (for this dosage form).
Hypersensitivity, organic diseases of the central nervous system, chronic renal failure. 
Use at pregnancy is not specified.

Overdose:

Symptoms: tremor, muscular weakness.
Treatment: gastric lavage, reception of absorbent carbon or other enterosorbents, purpose of salt laxatives. If necessary - oksigeno-and transfusion tera-
Pia. At neurologic symptoms enter thiamin.

Storage conditions:

List B. In the dry place, at a temperature not above 25 °C. To store in the places unavailable to children. 
Period of validity 4 years. Not to use after the period of validity specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Tablets of 500 mg; packaging planimetric cell 10, pack cardboard 1.