Улкарил®

General characteristics. Structure:

Active ingredient: 50 mg of an acyclovir.

Excipients: ketostearyl alcohol, half-oxameasures 407, vaseline white, oil mineral, propylene glycol, sodium lauryl sulfate, the water purified.

Pharmacological properties:

Pharmacodynamics. The acyclovir entering ULKARIL® cream is a synthetic analog of a nucleoside of thymidine. The thymidinekinase of the cells infected with a virus, will actively transform an acyclovir through a number of consecutive reactions to mono - di - and acyclovir triphosphate. Triphosphate of an acyclovir is built in instead of a deoxyguanosine virus DNA, inhibits a DNA polymerase of the last and suppresses replication process. At herpes the acyclovir prevents formation of new elements of rash, reduces probability of skin dissimination and visceral complications, accelerates formation of crusts.

Promotes decrease in pain in an acute phase of the surrounding herpes. Specificity and very high selectivity of action is also caused by its preferential accumulation in the cells affected with a herpes virus. Activity of an acyclovir against a herpes simplex virus (type 1) is twice higher, than at Cytarabinum, is 10 times higher, than at an idoksuridin, is 15 times higher, than at a trifluorotimidin and 160 times above, than at a vidarabin. Epstein-Burra is highly active concerning a virus of a herpes simplex (Herpes simplex (VHS)) of type 1 and 2, a virus of chicken pox and shingles (Varicella zoster (VZV)), a virus. It is moderately active concerning a cytomegalovirus.

Pharmacokinetics. At topical administration the acyclovir is slightly soaked up through skin and mucous membranes.

Indications to use:

- infections of skin and the mucous membranes caused by a virus of a herpes simplex of types I II, vk5lyuchaya herpes of lips, and also primary and recurrent genital herpes;

- primary and recurrent infections caused by a shingles virus (as a part of complex therapy);

- chicken pox (as a part of complex therapy).

Route of administration and doses:

Adults and children need to apply cream on an affected area of 6 times a day each 3 hours, excepting night time. Treatment needs to be begun at the first symptoms of an infection – in a prodromal stage. A course of treatment - 7 days.

Before putting cream it is necessary to wash up hands; it is important not to pound affected areas and not to touch them with a towel not to cause deteriorations in a course of a disease or transmission of infection. For avoidance of spread of a virus on other sites of skin it is necessary to use a fingerstall or rubber gloves.

Features of use:

It is not necessary to exceed the recommended dosage, frequency of applications and duration of treatment.

5% Ulkaril® cream should not be applied to the prevention of a recurrence of the infection caused by a herpes simplex virus.

To the persons having herpes on lips (especially in the presence of open defeats), it is necessary to follow strictly rules of precaution not to allow infection of other people.

5% Ulkaril® cream is intended only for drawing on integuments, it an eye is not recommended to apply on mucous membranes of an oral cavity, genitalias as development of the expressed local inflammation is possible.

Efficiency of treatment at cream use by that will be higher, than earlier it is begun.

Pregnancy and period of a lactation. It is necessary to be careful at purpose of Ulkaril® cream to women during pregnancy and to estimate estimated advantage for mother and possible risk for a fruit.

It is unknown whether the acyclovir gets into breast milk at topical administration therefore the feeding women should appoint Ulkaril® cream with care.

Features of influence of medicine on ability to manage the vehicle or potentially dangerous mechanisms

5% Ulkaril®ne cream influence ability to manage the vehicle and work with potentially dangerous mechanisms.

Side effects:

- reddening;

- itch;

- peeling;

- burning or pricking.

Seldom - allergic dermatitis.

Interaction with other medicines:

At external use of Ulkaril® interaction with other medicines is not revealed.

Contraindications:

- hypersensitivity or intolerance of components of drug.

Overdose:

About cases of overdose of 5% of ULKARIL® cream it was not reported.

Storage conditions:

To store in the dry, protected from light place, at a temperature not over 25 ºС. To store in the place, unavailable to children! Period of storage 2 years. Not to apply after the expiry date specified on packaging.

Issue conditions:

Without recipe

Packaging:

On 10 g of drug place in tubas aluminum with a plastic cap. On 1 tuba together with the instruction on a medical use in the state and Russian languages put in a pack from a cardboard.