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medicalmeds.eu Medicines Nootropic drugs. Pantogamum актив®

Pantogamum актив®

Препарат Пантогам актив®. ООО «ПИК-ФАРМА» Россия



General characteristics. Structure:

Structure for a dosage of 200 mg:
active agent: rats-Gopantenovy acid (D, L-Gopantenovaya acid) 200 mg; excipients: cellulose of microcrystallic 13,98 mg, magnesium stearate of 1,02 mg; solid gelatin capsules No. 1 (structure of capsules: titanium dioxide of 2%, iron oxide of yellow 0,6286%, gelatin to 100%).
Structure for a dosage of 300 mg:
active agent: rats-Gopantenovy acid (D, L-Gopantenovaya acid) 300 mg; excipients: cellulose of microcrystallic 20,97 mg, magnesium stearate of 1,53 mg; solid gelatin capsules No. 0 (structure of capsules: titanium dioxide of 2%, gelatin to 100%).

Description. Contents of capsules – powder of color, white or white with a yellowish shade. Solid gelatin capsules No. 1 of yellow color for a dosage of 200 mg and No. 0 of white color for a dosage of 300 mg.




Pharmacological properties:

Pharmacodynamics. Action Pantogamum актив® is connected with existence in its structure of gamma aminobutyric acid which directly influences on GAMKB-retseptor-a channel complex. Pantogamum актив® represents racemic mix of equal quantities a R-form of gopantenovy acid and its S-isomer. Presence of isomer improves transport and interaction of drug with GAMK receptor. Pantogamum актив® possesses more expressed nootropic and anticonvulsant action, than drugs of gopantenovy acid of the first generation. Pantogamum актив® increases resistance of a brain to a hypoxia and influence of toxic substances, stimulates anabolic processes in neurons, combines moderate sedative action with the soft stimulating effect. Possesses anti-asthenic and easy antialarming action. Reduces motor excitability, arranges behavior. Activates cerebration and working capacity. Causes braking patholologically of the raised vesical reflex and a tone of a detruzor.

Pharmacokinetics. It is quickly soaked up from digestive tract. Gets through a blood-brain barrier. It is not metabolized and removed in not changed look within 48 hours: about 70% of the accepted dose – with urine, about 30% - with a stake.


Indications to use:

• cognitive disturbances at organic lesions of a brain (including effects of neuroinfections and craniocereberal injuries) and neurotic frustration;
• the cerebrovascular insufficiency caused by atherosclerotic changes of vessels of a brain;
• extrapyramidal hyperkinesias (a myoclonus epilepsy, a chorea of Gentington, a hepatolenticular degeneration, Parkinson's disease, etc.), and also for treatment of the extrapyramidal syndrome caused by reception of neuroleptics;
• at epilepsy together with anticonvulsants;
• psychoemotional overloads, decrease in intellectual and physical effeciency, for improvement of concentration of attention and storing;
• neurogenic frustration of an urination (pollakiuria, imperative desires, imperative incontience of urine, enuresis);
• at schizophrenia in complex therapy.


Route of administration and doses:

Inside, in 15-20 minutes after food, 2-3 times a day preferably in morning and day time.
Capsules of 200 mg - on 1-4 capsules (0,2 - 0,8). Maximum daily dose of 12 capsules (2,4 g).
Capsules of 300 mg - on 1-3 capsules (0,3 - 0,9). Maximum daily dose of 8 capsules (2,4 g).
Course of treatment – 1-4 months, sometimes up to 6-12 months. In 3-6 months carrying out a repeated course of treatment is possible.


Features of use:

In the conditions of prolonged treatment co-administration of drug with others the nootropic and stimulating the central nervous system means is not recommended.


Side effects:

Allergic reactions (rhinitis, conjunctivitis, skin rashes) are in rare instances possible. In this case cancel drug. Undesirable reactions from TsNS are very seldom noted (a sleep disorder or drowsiness, a headache, dizziness, noise in the head). In this case reduce a drug dose.


Interaction with other medicines:

Prolongs action of barbiturates, strengthens effects of anticonvulsants, prevents by-effects of phenobarbital, carbamazepine, neuroleptics. The effect of Pantogamum актив® amplifies at a combination to glycine, etidronovy acid. Exponentiates effect of local anesthetics (Procainum).


Contraindications:

Hypersensitivity, acute serious illness of kidneys, pregnancy (1 trimester), lactation, age of the patient up to 18 years (there are no clinical trials on use of drug at earlier age).


Overdose:

Strengthening of symptomatology of by-effects. Treatment: absorbent carbon, gastric lavage, symptomatic therapy.


Storage conditions:

In the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children. Period of validity 3 years. Not to use after the expiry date specified on packaging.


Issue conditions:

According to the recipe


Packaging:

Capsules on 200 mg and 300 mg. For a dosage of 200 mg on 60 capsules, for a dosage of 300 mg on 30 or 50 capsules in banks poly-measured with covers. On 10 or 15 capsules in a blister strip packaging from a film of the polyvinyl chloride and printing aluminum foil varnished. 2 or 4 blister strip packagings on 15 capsules or 3 or 6 planimetric cell UPA - kovka on 10 capsules (for a dosage of 300 mg), or 4 blister strip packagings on 15 capsules or 6 blister strip packagings on 10 capsules (for a dosage of 200 mg), or to bank together with the application instruction place in a pack from a cardboard.



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