Trialgin

General characteristics. Structure:

Active ingredients: 500 mg of paracetamol, 32 mg of caffeine, 2 mg of chlorphenaminum of a maleate.

Excipients: starch corn, povidone, methylparaben, propylparaben, talc, magnesium stearate, starched glikolit sodium, colloid silicon dioxide, dye Supr's Tartrazine E 102.

Drug has the anesthetizing and febrifugal activity.

Pharmacological properties:

Pharmacodynamics. Drug has the anesthetizing and febrifugal activity.

The mechanism of effect of the main active ingredient of drug of paracetamol is caused by inhibition of synthesis of prostaglandins and other mediators of pain and an inflammation is preferential in the central nervous system. Caffeine strengthens and accelerates pharmakoterapevtichesky effect of paracetamol. Chlorphenaminum, blocking histamine H1 receptors, has the desensibilizing effect, reduces vascular and fabric permeability of a mucous membrane of upper respiratory tracts, eliminates an itch in eyes and a nose.

Indications to use:

- the acute respiratory, catarrhal diseases which are followed by the increased body temperature, a headache, a rhinedema (rhinitis);
- allergic rhinitis;
- nasopharyngitis;
- headaches of various etiology, muscular pains.

Route of administration and doses:

Pill is taken, without chewing, washing down with a small amount of water.

Drug is appointed to adults and children 12 years are more senior: in the acute period of a disease on 1 tablet 2-3 times a day, further - on ½ tablets 2-3 times a day.

At a headache – on 1 tablet in reception (no more than 3 tablets a day).

Children are from 7 to 12 years old – on ½ tablets 2-3 times a day.

Course of treatment – 5-7 days.

Features of use:

Drug is appointed with care to patients with a liver disease.

During treatment it is not recommended to be engaged in the activity requiring special attention, bystry mental and motor reactions.

Side effects:

Vozmozhnysukhost of mucous membranes, disturbance of accommodation, frustration of an urination, drowsiness, allergic reactions (skin rash, itch, small tortoiseshell).

Interaction with other medicines:

At co-administration of barbiturates, tricyclic antidepressants, and also alcohol intake the risk of gepatoksichesky action considerably increases.

Long reception of anticonvulsant drugs can reduce efficiency of paracetamol.

Drug strengthens effect of depressants of the central nervous system.

Simultaneous use with corticosteroids increases risk of development of glaucoma.

Contraindications:

The expressed abnormal liver functions and kidneys, deficit of enzyme glyukozo-6-fosfatdegidrogenazy, closed-angle glaucoma, a prostatauxe, pregnancy, the lactation period (feeding by a breast), age up to 7 years, hypersensitivity to drug components.

Overdose:

Simptomy:toshnota, vomiting, anorexia, abdominal pains, sweating strengthening. In rare instances the hepatotoxic action – thrombocytopenia, hemolitic anemia can be observed.

Treatment: A gastric lavage, or absorbent carbon in combination with a symptomatic treatment.

As the main antidote at overdose of paracetamol use N-Acetylcysteinum intravenously or inside.

Storage conditions:

List B. To store in the place protected from moisture and light, at a temperature not above 25 °C. To store in the place, unavailable to children. Period of validity 3 years.

Issue conditions:

Without recipe

Packaging:

Packaging On 10 tablets in a blister strip packaging; 1, 2 or 3 blister strip packagings put together with a leaf insert in a pack.

On 10, 15 or 20 tablets in bank polymeric. 1 bank together with a leaf insert in a pack.